A micro-droplet operating system based on surface acoustic wave chip array

Abstract

A micro-droplet operating system based on a surface acoustic wave chip array, including a plurality of interdigital transducer array units arranged on a lithium niobate substrate, each interdigital transducer array unit includes Plated 4 separate interdigital transducer arrays, the interdigital transducer arrays are symmetrically arranged left and right, front and rear, with a central reaction pool in the middle; the top of the interdigital transducer arrays is covered with no inert carrier liquid, as a diaphragm layer , there are liquid droplets on the diaphragm layer, and the interdigital transducer array is connected through the electrode circuit and the signal control circuit; the signal control circuit includes a signal generation module, which generates a sine wave signal, and outputs four frequency amplitudes through a parallel processing circuit Adjustable signal, the power amplification module acts on the amplified four-way signal to the interdigital transducer array to realize the driving, mixing and splitting of the droplet; the invention realizes the free movement of the droplet on the surface of the diaphragm layer, repeatability and integration high performance and can be applied on a large scale.

Description

technical field [0001] The invention belongs to the technical field of micro-droplet operating systems, in particular to a micro-droplet operating system based on a surface acoustic wave chip array. Background technique [0002] The application of micro-nano manufacturing technology, especially surface acoustic wave technology, integrates the operation of tiny droplets of biochemical reagents in a tiny space, which can realize the miniaturization and portability of the tiny droplet operating system, and can conduct a variety of tiny droplets such as blood. , saliva, driving and mixing of enzyme-containing reagents. The integration of microfluidic chips and integrated circuits makes it easy to realize the miniaturization and automation of instruments. [0003] The traditional biological reagent detection method is to extract biological samples, mix them in a reaction tank, let them stand, and detect the content of specific biomarkers after the reactants are fully mixed. How...

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Problems solved by technology

However, some biological reagent reactions (detection of neuron-specific enolase NSE) have defects such as damage to cell biocompatibility, mixing uniformity, and long reaction time of the mixture, which limits the first-time detection in the clinical medical process.

[0004] At present, the microfluidic technology for microdroplet processing often uses one or two interdigital transducers to generate acoustic waves to explore the driving effect, which leads to low repeatability and integration of microfluidic chip technology, making it impossible to achieve large-scale applications.

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