Method for improving water solubility of pterostilbene by utilizing embedding technology
A technology of pterostilbene and water solubility, which is applied in the field of improving the water solubility of pterostilbene using embedding technology, can solve the problems of affecting the medicinal effect of pterostilbene, low embedding rate, non-green, etc., and achieve good intestinal permeability, High embedding rate and good performance stability
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Embodiment 1
[0043] Embodiment 1 provides a kind of method utilizing embedding technique to improve pterostilbene water solubility, it is characterized in that, comprises the steps:
[0044] Step S1, preparation of quaternary ammonium salt of cyclodextrin hyperbranched derivatives: adding cyclodextrin hyperbranched derivatives and quaternizing reagents into an organic solvent, stirring and reacting at 30°C for 6 hours, and then removing the solvent by rotary evaporation, And wash the product with ether for 3-6 times, and then remove the ether by rotary evaporation to obtain the quaternary ammonium salt of the cyclodextrin hyperbranched derivative;
[0045] Step S2, embedding: dissolving pterostilbene in ethanol to form solution A, then heating and dissolving the quaternary ammonium salt of cyclodextrin hyperbranched derivatives prepared in step S1 with ethanol-water, and obtaining solution B after completely dissolving , then mix solution A and solution B, stir evenly, and then use high-pr...
Embodiment 2
[0049] Embodiment 2 provides a method for improving the water solubility of pterostilbene using embedding technology, which is basically the same as in embodiment 1, except that the cyclodextrin hyperbranched derivatives, quaternization reagents, and organic solvents described in step S1 The mass ratio is 3.5:0.15:12; the quaternization reagent is 4-chlorobutanol; the organic solvent is ether; the mass ratio of pterostilbene and ethanol described in step S2 is 1:4.5; in step S2 The mass ratio of solution A to solution B is 3.5:1; the temperature of heating and dissolving described in step S2 is 50°C; the pressure of high-pressure homogenization described in step S2 is 45MPa, and the temperature is 30°C; described in step S2 The freeze-dried temperature was -33°C.
Embodiment 3
[0051] Embodiment 3 provides a method for improving the water solubility of pterostilbene using embedding technology, which is basically the same as in embodiment 1, except that the cyclodextrin hyperbranched derivatives, quaternizing reagents, and organic solvents described in step S1 The mass ratio is 4:0.2:13; the quaternization reagent is (S)-3-chloro-1,2-propanediol; the organic solvent is ethyl acetate; the pterostilbene, ethanol in step S2 The mass ratio is 1:5; the mass ratio of solution A and solution B described in step S2 is (3-5):1; the temperature of heating and dissolving described in step S2 is 60°C; the high-pressure homogenization described in step S2 The pressure is 50MPa, and the temperature is 30°C; the freeze-drying temperature in step S2 is -35°C.
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