Preparation method of N-diethylaminoacetyl-2,6-dimethylaniline quaternary ammonium salt
A technology of diethylaminoacetyl and dimethylaniline, applied in the field of pharmaceutical synthesis, can solve the problems of unstable raw materials, low purity, low yield and the like, and achieves a complete reaction, high yield and purity, and economical and environmentally friendly yields. Effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Example Embodiment
[0026]Example 1
[0027]It is weighed 24.2 g 2-bromo-N- (2,6-dimethylphenyl) acetamide to add 100 mL of acetonitrile solution, add 21.1 g of diethyl ethanol, heating to 75 to 80 ° C. Stir, TLC detection reaction is completed. After falling to the room temperature QX-314-OH solid, the obtained QX-314-OH was added to 50 ml of heating and dissolved in 50 ml of anhydrous ether, cooled to 20 ° C holding the stirring grafting crystalline 3h, filtered, the resulting filter cake 45 ° C vacuum dry dry QX-314-OH was obtained, and the yield was 73.4%, HPLC purity 99.56%.
Example Embodiment
[0028]Example 2
[0029]It is weighed with 24.2 g of 2-bromo-N- (2,6-dimethylphenyl) acetamide to add 100 ml of toluene solution, add 21.1 g of diethylene ethanol, heating to 80 to 85 ° C, stir, TLC detection reaction After lowering to the room temperature QX-314-OH solid, the obtained QX-314-OH was added to 60 mL of methanol and heat dissolved, and the temperature was lowered to 10 ° C to heat the stirred grafting crystalline 2H, filtered, the resulting filter cake 45 ° C vacuum dry QX -314-oh, the yield was 71.7%, HPLC purity 99.48%.
Example Embodiment
[0030]Example 3
[0031]It is weighed 24.2 g 2-bromine-N- (2,6-dimethylphenyl) acetamide, adding 16 ml of acetonitrile solution, 16.4 g (0.14 mol) diethyl ethanol was added, and the reaction was stirred to 60 ~ 65 ° C, After the TLC was detected, it fell to the room temperature QX-314-OH solid, and the obtained QX-314-OH was added to 50 ml of heating and dissolved, and the temperature was lowered to 25 ° C to heat the stirred alcohol 3H, filtered, the resulting filter cake The QX-314-OH was dried in vacuo to 45 ° C, and the yield was 70.5%, HPLC purity 99.51%.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap