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Sustained-release pellet containing huperzine A microcapsules and preparation method thereof

A technology of huperzine A and sustained-release pellets, which is applied in the direction of medical preparations containing active ingredients, medical preparations with non-active ingredients, and pharmaceutical formulas, which can solve the problems of inconvenient use for elderly patients and achieve good sustained release Effect, Enhanced Bioavailability, Enhanced Effect of Sustained Release Effect

Pending Publication Date: 2021-02-26
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is: the problem that the dosage form of existing huperzine A is inconvenient for elderly patients

Method used

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  • Sustained-release pellet containing huperzine A microcapsules and preparation method thereof
  • Sustained-release pellet containing huperzine A microcapsules and preparation method thereof
  • Sustained-release pellet containing huperzine A microcapsules and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0026] A sustained-release pellet containing huperzine A microcapsules and a preparation method thereof, the formulation of which is shown in Table 1.

[0027] Table 1

[0028] components effect Dosage Huperzine A Microcapsules main ingredient 0.1mg HPMC K4M Adhesive 6mg Poloxamer 407 thickener 0.4mg microcrystalline cellulose Pilling accessories 20mg lactose Pilling accessories 14mg Mannitol Pilling accessories 8mg Sodium carboxymethyl cellulose Pilling accessories 12mg purified water solvent 60mL

[0029] Preparation method: ① Preparation of huperzine A microcapsules: Add 50 mg of huperzine A raw material into 200 mL of 0.5% sodium alginate aqueous solution, stir well, then drop 100 mL of 1% chitosan-acetic acid aqueous solution into the above-mentioned In the turbid liquid, the huperzine A microcapsule emulsion is prepared by complex coacervation, and then the huperzine A microcapsule ...

Embodiment 2

[0037] A sustained-release pellet containing huperzine A microcapsules and a preparation method thereof, the formulation of which is shown in Table 3.

[0038] table 3

[0039] components effect Dosage Huperzine A Microcapsules main ingredient 0.2mg HPMC K4M Adhesive 8mg Poloxamer 407 thickener 0.6mg polyethylene glycol 6000 plasticizer 2mg microcrystalline cellulose Pilling accessories 20mg lactose Pilling accessories 16mg Mannitol Pilling accessories 8mg Sodium carboxymethyl cellulose Pilling accessories 15mg purified water solvent 70mL

[0040] Preparation method: ① Preparation of huperzine A microcapsules: Add 50 mg of huperzine A raw material into 200 mL of 0.5% sodium alginate aqueous solution, stir well, then drop 100 mL of 1% chitosan-acetic acid aqueous solution into the above-mentioned In the turbid liquid, the huperzine A microcapsule emulsion is prepared by complex co...

Embodiment 3

[0048] A sustained-release pellet containing huperzine A microcapsules and a preparation method thereof, the formulation of which is shown in Table 5.

[0049] table 5

[0050] components effect Dosage Huperzine A Microcapsules main ingredient 0.3mg HPMC K4M Adhesive 10mg Carbomer 971P NF thickener 0.9mg Poloxamer 407 thickener 0.8mg polyethylene glycol 6000 plasticizer 2mg microcrystalline cellulose Pilling accessories 18mg lactose Pilling accessories 20mg Mannitol Pilling accessories 10mg Sodium carboxymethyl cellulose Pilling accessories 18mg purified water solvent 80mL

[0051] Preparation method: dissolve the binder (HPMC K4M) and additives (poloxamer 407, polyethylene glycol 6000 and carbomer 971P NF) in pure water, and the resulting solution is used as a wetting agent; then the wetting agent It is uniformly mixed with huperzine A microcapsule powder and pelletizin...

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Abstract

The invention discloses a sustained-release pellet containing huperzine A microcapsules and a preparation method thereof. The sustained-release pellet containing the huperzine A microcapsules comprises raw materials, by weight, 0.05-0.40 percent of the huperzine A microcapsules, 0.1-20 percent of an adhesive, 10-40 percent of pelleting auxiliary materials, 0.01-8 percent of an additive and the balance of water. The preparation method comprises the following steps of dissolving the adhesive and the additive in pure water to obtain a solution as a wetting agent; uniformly mixing the wetting agent with the huperzine A microcapsules and pelleting auxiliary materials to prepare a soft material; and preparing the soft material into pellets by adopting an extrusion rounder, drying and screening.The sustained-release pellet is slow and stable in release effect, relatively complete in dissolution amount, good in particle size uniformity, round in particle, increased in smoothness, convenient to swallow and capable of achieving a good treatment effect.

Description

technical field [0001] The invention relates to a slow-release pellet containing huperzine A microcapsules and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] The oral sustained and controlled release drug delivery system is generally a preparation that is administered 1-2 times a day, which is convenient for patients to take and improve medication compliance. This type of preparation can stabilize the blood drug concentration and reduce the adverse reactions of the drug while ensuring the effective therapeutic concentration , to avoid the occurrence of drug resistance. [0003] Sustained-release pellets are uniformly dispersed in the gastrointestinal tract, which can reduce drug irritation and effectively reduce toxic and side effects. At the same time, the production efficiency is high, the dose can be divided, and the advantages in transportation, storage and administration are more prominent. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/4748A61K47/32A61K47/38A61P25/28
CPCA61K9/1635A61K9/1652A61K31/4748A61P25/28
Inventor 邱芳菲刘清雷
Owner SHANGHAI INST OF TECH
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