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Preparation and application of efficient hemostatic and antibacterial multifunctional material

A hemostatic, antibacterial and multi-functional technology, applied in the field of medical materials, can solve the problems of inability to prevent bacterial infection, hidden dangers of wound healing, and increase the death of patients, and achieve the effect of improving coagulation effect, no toxic side effects, and good biocompatibility.

Active Publication Date: 2021-02-26
GUANGXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many deficiencies in the hemostatic materials currently on the market. Their functions are single. On the one hand, they cannot quickly stop bleeding while preventing bacterial infection, which increases the risk of death due to infection; Response to bacterial invasion and infection, and in-situ antibacterial without repeated wound dressing replacement is a great hidden danger to wound healing. In-situ antibacterial means that there is no need to replace the hemostatic material, which greatly avoids the secondary damage of the wound. Secondary injury, it has a great promotion effect on wound healing

Method used

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  • Preparation and application of efficient hemostatic and antibacterial multifunctional material
  • Preparation and application of efficient hemostatic and antibacterial multifunctional material
  • Preparation and application of efficient hemostatic and antibacterial multifunctional material

Examples

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Effect test

Embodiment 1

[0049] A preparation method of an efficient hemostatic and antibacterial multifunctional material, comprising the following steps:

[0050] 1) Preparation of hemostatic and antibacterial layer

[0051] 1.1) Weigh 15 g of starch and place it in a beaker filled with 0.05% (w / v) NaOH solution, and stir it magnetically for 4 hours to remove protein. Finally, it is filtered with a standard test sieve to remove coarse fibers, and then dried to obtain pretreated starch. Weigh 7g of pretreated starch and place it in a three-necked flask, add hydrochloric acid with a concentration of 1% (w / v) therein to form a starch emulsion with a concentration of 20% (w / v), then add and stir at 45°C for 100min , and finally adjust its pH value to 7.0 with saturated sodium bicarbonate solution, filter, wash with water three times, and then dry to obtain acid hydrolyzed starch. Weigh 5 g of acid-hydrolyzed starch and place it in a three-neck flask containing disodium hydrogen phosphate-citric acid b...

Embodiment 2

[0064] 1) The preparation of the hemostatic and antibacterial layer, the operation steps are as follows:

[0065]1.1) Weigh 15 g of starch and place it in a beaker filled with 0.2% (w / v) NaOH solution, and stir it magnetically for 2 hours to remove protein. Finally, it is filtered with a standard test sieve to remove coarse fibers, and then dried to obtain pretreated starch. Weigh 7g of pretreated starch and place it in a three-necked flask, add hydrochloric acid with a concentration of 3% (w / v) therein to form a starch emulsion with a concentration of 40% (w / v), then add and stir at 50°C for 70min , and finally adjust its pH value to 7.0 with saturated sodium bicarbonate solution, filter, wash with water three times, and then dry to obtain acid hydrolyzed starch. Weigh 5 g of acid hydrolyzed starch and place it in a three-neck flask containing disodium hydrogen phosphate-citric acid buffer (pH=4.0), preheat at 40°C for 0.5 h, add a small amount of disodium hydrogen phosphate...

Embodiment 3

[0078] 1) The preparation of the hemostatic and antibacterial layer, the operation steps are as follows:

[0079] 1.1) Weigh 14g of starch and place it in a beaker filled with 0.5% (w / v) NaOH solution, and stir it magnetically for 1 hour to remove protein. Finally, it is filtered with a standard test sieve to remove coarse fibers, and then dried to obtain pretreated starch. Weigh 6g of pretreated starch and place it in a three-necked flask, add hydrochloric acid with a concentration of 5% (w / v) therein to form a starch emulsion with a concentration of 20% (w / v), then add and stir at 65°C for 30min , and finally adjust its pH value to 7.0 with saturated sodium bicarbonate solution, filter, wash with water three times, and then dry to obtain acid hydrolyzed starch. Weigh 4g of acid-hydrolyzed starch and place it in a three-necked flask containing disodium hydrogen phosphate-citric acid buffer (pH=4.0). Diluted α-amylase and glucoamylase solution, so that the amount of compound...

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Abstract

The invention discloses preparation and application of an efficient hemostatic and antibacterial multifunctional material. The material is divided into a hemostatic and antibacterial layer, an adhesion layer, a detection layer and an antibacterial layer from inside to outside according to the contact with a wound surface, wherein the adhesion layer can adhere to the skin to prevent blood from flowing out, and the hemostatic and antibacterial layer can quickly absorb blood moisture to promote the increase of platelet concentration, thereby further improving the blood coagulation effect; the detection layer has the ability to respond to bacterial infection detection by loading reporter molecules, and the principle is that the reporter molecules react with enzymes secreted by pathogenic bacteria to generate fluorescent molecules; and a protective layer loaded with a bacteriostatic agent can inactivate bacteria. The multifunctional material of the invention can perform whole-process intervention from wound hemostasis to wound healing, thereby avoiding the invasion and infection of bacteria, avoiding secondary damage to the wound caused by repeated replacement of dressings, and ensuringthe life safety of patients to the maximum extent.

Description

technical field [0001] The invention relates to the technical field of medical materials, and more specifically relates to the preparation and application of a highly efficient hemostatic and antibacterial multifunctional material, which is used for rapid and effective hemostasis of skin wounds, bacterial infection response, antibacterial and wound healing promotion. Background technique [0002] With the widespread use of antibiotics, the problem of bacterial resistance is becoming more and more serious, which poses great challenges to clinical treatment. A photosensitizer is an antibacterial drug that can kill bacteria in situ by relying on the participation of oxygen to generate active oxygen species such as singlet oxygen under the excitation of a light source in an appropriate wavelength range. This photodynamic antibacterial therapy is not easy to produce bacteria Drug resistance, relying on the advantage of being driven by light energy without consuming the photosensi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18A61L15/20A61L15/26A61L15/28A61L15/42A61L15/44A61L15/46A61L15/58
CPCA61L15/28A61L15/26A61L15/20A61L15/18A61L15/42A61L15/44A61L15/46A61L15/58A61L2400/04A61L2300/404A61L2300/406A61L2300/104A61L2300/208A61L2300/216C08L51/02C08L1/02C08L1/12C08L71/02
Inventor 刘海波杨浩王静梁躍辉
Owner GUANGXI UNIV
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