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Bioactive bionic fiber connective tissue with multistage ordered structure, preparation method, bionic tendon and bionic ligament

A biologically active and ordered structure technology, applied in the fields of biologically active bionic fibrous connective tissue and preparation, bionic ligament, and bionic tendon, can solve the problems of difficult to achieve orderly regulation of multi-scale structures, complicated processes, etc., and is conducive to industrial promotion. and application, preparation process is simple, easy to operate

Active Publication Date: 2021-03-02
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing materials for preparing artificial tendons or ligaments are relatively complex and difficult to achieve orderly regulation of multi-scale structures

Method used

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  • Bioactive bionic fiber connective tissue with multistage ordered structure, preparation method, bionic tendon and bionic ligament
  • Bioactive bionic fiber connective tissue with multistage ordered structure, preparation method, bionic tendon and bionic ligament
  • Bioactive bionic fiber connective tissue with multistage ordered structure, preparation method, bionic tendon and bionic ligament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Prepare 40 ml of Ca(NO 3 ) 2 4H 2 O and Na 2 SiO 3 9H 2 O mixed aqueous solution, packed into a polytetrafluoroethylene liner, covered with a metal hydrothermal kettle, and reacted at 200°C for 24 hours. The crude product obtained by the reaction is washed with water three times to obtain the hydrated calcium silicate nanowire.

[0057] The transmission electron microscope (TEM) photo of the active nanomaterial sample (calcium silicate nanowire) prepared in this embodiment is as attached figure 2 shown.

[0058] attached figure 2 It shows that the calcium silicate nanowires prepared in this example have a diameter of 20-50 nm and a length of 1-3 μm.

Embodiment 2

[0060] Take 0.2 grams of calcium silicate nanowires in Example 1 and mix them with 2 grams of alginic acid evenly, then add 12 grams of deionized water and stir evenly to form a printing paste. The 27G printing needle is selected, and the composite material is 3D printed according to the pre-set printing parameters. The specific parameters include a single layer thickness of 0.15mm, a printing speed of 2mm / s, and an air pressure of 500KPa. After the 3D printing was completed, the semi-finished composite hydrogel scaffold was prepared in 1 mol / L CaCl 2 After cross-linking in aqueous solution for 6 hours, wash off the residual CaCl on the surface of the composite hydrogel scaffold with deionized water 2 . As a control, use the same method to mix the slurry directly with CaCl 2 Aqueous solution crosslinking.

[0061] The scanning electron microscope (SEM) photo of the hydrogel scaffold sample prepared in this embodiment is as attached image 3 Shown in a.

[0062] attached ...

Embodiment 3

[0064] On the basis of Example 2, the 27G printing needles were replaced with 23G printing needles and 25G printing needles respectively, and other steps remained unchanged.

[0065] attached Figure 4 In a-c, scanning electron microscope (SEM) photos of hydrogel scaffold samples prepared using 23G, 25G and 27G needles, respectively. It can be seen that different needle sizes have certain influence on the orientation arrangement of calcium silicate nanowires. Specifically, as the size of printing needles decreases, the alignment degree of calcium silicate nanowires gradually increases.

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Abstract

The invention discloses a bioactive bionic fiber connective tissue with a multistage ordered structure, a preparation method, a bionic tendon and a bionic ligament. The preparation method of the bioactive bionic fiber connective tissue comprises the following steps: mixing an active nano-material and bio-ink to obtain printing slurry, wherein the active nano-material contains osteogenic and / or tendon-forming active ions; carrying out 3D printing on the printing slurry to prepare a composite hydrogel scaffold; and stretching and drying the composite hydrogel scaffold to prepare the bioactive bionic fiber connective tissue. The preparation method can be used for preparing the bioactive bionic fiber connective tissue with a multistage ordered structure, has the advantages of simple preparation process and easiness in operation, and is beneficial to industrial popularization and application.

Description

technical field [0001] The invention relates to the technical field of medical biomaterials, in particular to a bioactive bionic fibrous connective tissue with a multi-level ordered structure, a preparation method thereof, and bionic tendons and bionic ligaments. Background technique [0002] Each piece of skeletal muscle is divided into two parts, the belly and the tendon. The tendon is composed of dense fibrous connective tissue, and the skeletal muscle is attached to the bone through the tendon. Ligaments are dense fibrous connective tissues that attach to the movable parts of bones but limit the range of motion of the bones to avoid injury. In general, ligaments connect bones to bones, while tendons connect bones to muscles. [0003] Sports injuries represented by tendon loss or ligament loss are constantly disturbing the healthy life of modern people, and patients with severe injuries often require surgical treatment. Although the surgical operation represented by art...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52A61L27/44A61L27/46A61L27/54B33Y10/00B33Y70/10B33Y80/00B82Y30/00B82Y40/00
CPCA61L27/52A61L27/46A61L27/446A61L27/54B82Y30/00B82Y40/00B33Y70/10B33Y10/00B33Y80/00A61L2430/10A61L2400/12
Inventor 黄鹏杨晨罗永祥魏销玥林静
Owner SHENZHEN UNIV
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