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Preparation of polyethylene glycol sodium potassium oral pharmaceutical preparation

A technology of polyethylene glycol sodium potassium powder and polyethylene glycol sodium potassium powder, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations with non-active ingredients, etc., and can solve problems such as long dissolution time, trouble taking, and patient discomfort , to achieve the effect of fast dissolution

Inactive Publication Date: 2021-03-16
TIANJIN PRECEDE MEDICAL TRADE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] The polyethylene glycol sodium potassium powder or granule disclosed in the prior art is used to dissolve the preparation in water and then take it. If the amount of water is large, the powder or granule is easier to dissolve, but the large amount of water will cause discomfort to the patient. NuLYTELY's products require 4L of water
Mervicel belongs to the category with less water. Dissolve 13.8 grams per pack in about 125ml of water and then take it. Less water can solve the problem of satiety or gastrointestinal irritation, but it takes a long time for the drug to dissolve, causing trouble for taking
[0016] In order to solve the problem of long dissolution time, in 2000, U.S. Patent 6,444,198 disclosed an effervescent system, but the amount of effervescent agent would cause discomfort in the patient's mouth. In 2012, U.S. Patent 8,753,618 also disclosed an effervescent system, which faced similar problem

Method used

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  • Preparation of polyethylene glycol sodium potassium oral pharmaceutical preparation
  • Preparation of polyethylene glycol sodium potassium oral pharmaceutical preparation
  • Preparation of polyethylene glycol sodium potassium oral pharmaceutical preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Preparation of polyethylene glycol sodium potassium powder:

[0043] Each 15g serving contains the following ingredients:

[0044]

[0045]

[0046] The preparation method is as follows:

[0047] (1) Weigh sodium bicarbonate, sodium chloride, potassium chloride, xylitol, polyethylene glycol 3350, put them into a blender, spray an appropriate amount of absolute ethanol to moisten under stirring, and stir continuously for 30 minutes after wetting, take out;

[0048] (2) fully dry, the coarse powder after drying is through grinding and pulverizing, crosses 80 mesh sieves, obtains powder;

[0049] (3) Ready to pack.

Embodiment 2

[0051] Preparation of polyethylene glycol sodium potassium powder:

[0052] Each 15g serving contains the following ingredients:

[0053]

[0054] The preparation method is as follows:

[0055] (1) Weigh sodium bicarbonate, sodium chloride, potassium chloride, xylitol, polyethylene glycol 3350, and orange essence into a blender, spray an appropriate amount of absolute ethanol to moisten under stirring, and stir continuously for 30 minutes after wetting. minutes, take out;

[0056] (2) fully dry, the coarse powder after drying is through grinding and pulverizing, crosses 80 mesh sieves, obtains powder;

[0057] (3) Ready to pack.

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Abstract

The invention relates to a preparation method of a polyethylene glycol sodium potassium oral pharmaceutical preparation. The method comprises the following steps of (1) weighing sodium bicarbonate, sodium chloride, potassium chloride, xylitol and polyethylene glycol 3350, putting the components into a stirrer, spraying a proper amount of absolute ethyl alcohol in stirring for wetting, performing continuous stirring for 30 minutes after wetting, and taking out a mixture; (2) performing full drying, grinding and crushing dried coarse powder, and sieving the grounded and crushed powder with an 80-mesh sieve to obtain powder; and (3) performing sub-packaging to obtain the polyethylene glycol sodium potassium oral pharmaceutical preparation.

Description

technical field [0001] The invention relates to the preparation of a pharmaceutical preparation, in particular to the preparation of a sodium potassium polyethylene glycol oral pharmaceutical preparation. Background technique [0002] Polyethylene glycol sodium potassium powder, a medicine for treating constipation, ingredients: each contains [0003] [0004] The following ingredients are included in the flavoring: acacia solids, maltodextrin, orange oil, lemon oil, citral, citric acid and water. [0005] The polyethylene glycol sodium potassium powder described above has a trade name of Movic, which was launched in the UK on December 18, 1995, and domestic imported products are listed. Similar products listed abroad also include polyethylene glycol sodium potassium powder with trade name: GoLYTELY and trade name: NuLYTELY. [0006] Polyethylene glycol sodium potassium powder has a laxative effect due to the penetration of polyethylene glycol in the intestinal tract, a...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/14A61K9/16A61K31/77A61K33/00A61K47/26A61P1/10
CPCA61K31/77A61K33/14A61K33/00A61K47/26A61K9/145A61K9/1623A61P1/10A61K2300/00
Inventor 杨兵
Owner TIANJIN PRECEDE MEDICAL TRADE
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