Microsphere-based stent as well as preparation method and application thereof

A microsphere matrix and microsphere technology, which is applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of weak combination of drug-loaded microspheres and 3D printing scaffolds, poor drug release performance, and complex preparation processes. , to achieve the effect of strong drug release ability, increase surface adhesion, and improve dispersion performance

Pending Publication Date: 2021-03-16
GUANGDONG PROV MEDICAL INSTR INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the microsphere-containing hydrogel 3D printing scaffolds produced by the above-mentioned prior art are ubiquitous. 1) The matrix material of the drug-loaded microspheres is mostly a natural polymer, and the controlled release performance of the drug is not as good as that of the matrix

Method used

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  • Microsphere-based stent as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0034]Example 1

[0035] This embodiment provides a microsphere-based scaffold, prepared according to the following steps:

[0036] Use 650-mesh and 1600-mesh standard sieves to sieve the VEGF-loaded polybutylene succinate (molecular weight 15,000 Daltons) microspheres (hereinafter referred to as "drug-loaded microspheres") to obtain 10-21 μm-loaded microspheres. drug microspheres. 12 g of gelatin was dissolved in 30 mL of deionized water at 70°C, and incubated for 2 h to obtain a gelatin solution with a concentration of 40%, which was used as a dispersant solution; 0.6 g of methylcellulose was dissolved in 6 mL of deionized water to obtain a concentration of 10% of methylcellulose. The solution was used as a binder solution; after the gelatin solution was cooled, the drug-loaded microspheres were dispersed in the above dispersant solution, stirred at 3000 rpm for 10 min, and then the drug-loaded microspheres were drained; The drug microspheres were added to the above binder...

Example Embodiment

[0037] Example 2

[0038] This embodiment provides a microsphere-based scaffold, prepared according to the following steps:

[0039] Use 100-mesh and 140-mesh standard sieves to sieve polylactic acid (molecular weight 60,000 Daltons) microspheres loaded with BMP-7 (hereinafter referred to as "drug-loaded microspheres") to obtain drug-loaded microspheres of 104-150 μm . 35g of gelatin was dissolved in 50mL of deionized water at 70°C, and incubated for 2 hours to obtain a gelatin solution with a concentration of 70%, which was used as a dispersant solution; The polyvinyl alcohol 124 solution was used as a binder solution; after the gelatin solution was cooled, the drug-loaded microspheres were dispersed in the above dispersant solution, ultrasonically dispersed for 3 min at 25KHZ, 800W, and then the drug-loaded microspheres were drained; Stir at 1000rpm Then, add the drained drug-loaded microspheres into the above-mentioned binder solution, and continue stirring for 30 minutes...

Example Embodiment

[0040] Example 3

[0041] This embodiment provides a microsphere-based scaffold, prepared according to the following steps:

[0042] Use 270 mesh and 1600 mesh standard sieves to sieve the polylactic acid-glycolic acid copolymer (molecular weight of 30,000 Daltons) microspheres (hereinafter referred to as "drug-loaded microspheres") loaded with alendronate sodium to obtain 10 ~53 μm drug-loaded microspheres. 3g of polyethylene glycol 400 was dissolved in 20mL of deionized water to obtain a solution of polyethylene glycol 400 with a concentration of 15%, which was used as a dispersant solution; 1.0g of polyvinyl alcohol 1799 was dissolved in 2mL of deionized water at 90 °C, and kept for 2h to obtain the concentration It is a 50% polyvinyl alcohol 1799 solution as a binder solution; the drug-loaded microspheres are dispersed in the above dispersant solution, stirred at 500 rpm for 15 min, and then the drug-loaded microspheres are drained; The dry drug-loaded microspheres were ...

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Abstract

The invention discloses a microsphere-based stent as well as a preparation method and application thereof, the microsphere-based stent comprises a drug-loaded microsphere and a dispersing agent coating the surface of the drug-loaded microsphere, the drug-loaded microsphere comprises a polymer microsphere and a drug loaded in the polymer microsphere, the polymer microsphere is made of degradable polyester, and the dispersing agent is a hydrophilic high polymer material. According to the invention, the dispersing agent is used for coating the surfaces of the drug-loaded microspheres, the dispersing performance of the drug-loaded microspheres in the binder can be improved on the premise that the cohesiveness of the drug-loaded microspheres is not remarkably reduced, certain flowability can bekept before curing after the drug-loaded microspheres are subsequently mixed with the binder, which is conducive to subsequent 3D printing, and has good application prospects in tissue repair and regeneration materials.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a microsphere-based scaffold and its preparation method and application. Background technique [0002] With the continuous development of medicine, pharmacy, and biology, new drugs for various diseases emerge in an endless stream, but how to release drugs continuously and stably in the body is still a difficult problem. Regardless of oral administration or intravenous injection, there will be a "peak-valley" phenomenon in the change of blood drug concentration. If the drug concentration is too high, it will cause relatively large toxic and side effects, while if it is too low, the therapeutic effect will not be achieved. Although the emerging bioactive macromolecular drugs are highly effective, they have a short biological half-life and are easily inactivated, which is also a problem that plagues drug developers. Use appropriate biomaterials to embed or adsorb drugs to form a...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L27/50A61L27/18A61L27/56B33Y70/10B33Y70/00B33Y80/00B33Y10/00
CPCA61L27/54A61L27/50A61L27/18A61L27/56B33Y70/10B33Y70/00B33Y80/00B33Y10/00A61L2430/02A61L2300/602
Inventor 许为康林承雄吴婷婷
Owner GUANGDONG PROV MEDICAL INSTR INST
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