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Microsphere-based stent as well as preparation method and application thereof

A microsphere matrix and microsphere technology, which is applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of weak combination of drug-loaded microspheres and 3D printing scaffolds, poor drug release performance, and complex preparation processes. , to achieve the effect of strong drug release ability, increase surface adhesion, and improve dispersion performance

Pending Publication Date: 2021-03-16
GUANGDONG PROV MEDICAL INSTR INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the microsphere-containing hydrogel 3D printing scaffolds produced by the above-mentioned prior art are ubiquitous. 1) The matrix material of the drug-loaded microspheres is mostly a natural polymer, and the controlled release performance of the drug is not as good as that of the matrix material which is degradable polyester. ; 2) The drug-loaded microspheres are combined on the surface of the printed 3D printed stent, and the combination of the drug-loaded microspheres and the 3D printed stent is not firm; 3) The preparation process is complicated and difficult to industrialize

Method used

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  • Microsphere-based stent as well as preparation method and application thereof

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Embodiment 1

[0035] This embodiment provides a microsphere-based scaffold, which is prepared according to the following steps:

[0036] Use 650 mesh and 1600 mesh standard sieves to sieve polybutylene succinate (molecular weight: 15,000 Dalton) microspheres loaded with VEGF (hereinafter referred to as "drug-loaded microspheres") to obtain 10-21 μm loaded microspheres. drug microspheres. Dissolve 12g of gelatin in 30mL of 70°C deionized water and keep it warm for 2 hours to obtain a gelatin solution with a concentration of 40% as a dispersant solution; dissolve 0.6g of methylcellulose in 6mL of deionized water to obtain a concentration of 10% methylcellulose solution, as a binder solution; after the gelatin solution is cooled, disperse the drug-loaded microspheres in the above-mentioned dispersant solution, stir at 3000rpm for 10min, and then drain the drug-loaded microspheres; Add the drug microspheres to the above binder solution, and continue to stir for 10 minutes to obtain a uniform s...

Embodiment 2

[0038] This embodiment provides a microsphere-based scaffold, which is prepared according to the following steps:

[0039] Use 100-mesh and 140-mesh standard sieves to sieve BMP-7-loaded polylactic acid (molecular weight: 60,000 Daltons) microspheres (hereinafter referred to as "drug-loaded microspheres") to obtain drug-loaded microspheres of 104-150 μm . Dissolve 35g of gelatin in 50mL of 70°C deionized water, keep it warm for 2 hours to obtain a gelatin solution with a concentration of 70%, and use it as a dispersant solution; Polyvinyl alcohol 124 solution, as the binder solution; after the gelatin solution is cooled, disperse the drug-loaded microspheres in the above-mentioned dispersant solution, ultrasonically disperse at 25KHZ, 800W for 3min, then drain the drug-loaded microspheres; stir at 1000rpm Next, add the drained drug-loaded microspheres to the above binder solution, and continue stirring for 30 minutes to obtain a uniform slurry of extrudable drug-loaded micros...

Embodiment 3

[0041] This embodiment provides a microsphere-based scaffold, which is prepared according to the following steps:

[0042] Use standard sieves of 270 mesh and 1600 mesh to sieve the polylactic acid-glycolic acid copolymer (molecular weight is 30,000 Daltons) microspheres loaded with alendronate sodium (hereinafter referred to as "medicine-loaded microspheres") to obtain 10 ~53 μm drug-loaded microspheres. Dissolve 3g polyethylene glycol 400 in 20mL deionized water to obtain a polyethylene glycol 400 solution with a concentration of 15% as a dispersant solution; dissolve 1.0g polyvinyl alcohol 1799 in 2mL 90°C deionized water, and keep it warm for 2 hours to obtain the concentration 50% polyvinyl alcohol 1799 solution, as the binder solution; disperse the drug-loaded microspheres in the above-mentioned dispersant solution, stir at 500rpm for 15min, then drain the drug-loaded microspheres; under stirring at 500rpm, drain the Add the dry drug-loaded microspheres to the above bin...

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Abstract

The invention discloses a microsphere-based stent as well as a preparation method and application thereof, the microsphere-based stent comprises a drug-loaded microsphere and a dispersing agent coating the surface of the drug-loaded microsphere, the drug-loaded microsphere comprises a polymer microsphere and a drug loaded in the polymer microsphere, the polymer microsphere is made of degradable polyester, and the dispersing agent is a hydrophilic high polymer material. According to the invention, the dispersing agent is used for coating the surfaces of the drug-loaded microspheres, the dispersing performance of the drug-loaded microspheres in the binder can be improved on the premise that the cohesiveness of the drug-loaded microspheres is not remarkably reduced, certain flowability can bekept before curing after the drug-loaded microspheres are subsequently mixed with the binder, which is conducive to subsequent 3D printing, and has good application prospects in tissue repair and regeneration materials.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a microsphere-based scaffold and its preparation method and application. Background technique [0002] With the continuous development of medicine, pharmacy, and biology, new drugs for various diseases emerge in an endless stream, but how to release drugs continuously and stably in the body is still a difficult problem. Regardless of oral administration or intravenous injection, there will be a "peak-valley" phenomenon in the change of blood drug concentration. If the drug concentration is too high, it will cause relatively large toxic and side effects, while if it is too low, the therapeutic effect will not be achieved. Although the emerging bioactive macromolecular drugs are highly effective, they have a short biological half-life and are easily inactivated, which is also a problem that plagues drug developers. Use appropriate biomaterials to embed or adsorb drugs to form a...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L27/50A61L27/18A61L27/56B33Y70/10B33Y70/00B33Y80/00B33Y10/00
CPCA61L27/54A61L27/50A61L27/18A61L27/56B33Y70/10B33Y70/00B33Y80/00B33Y10/00A61L2430/02A61L2300/602
Inventor 许为康林承雄吴婷婷
Owner GUANGDONG PROV MEDICAL INSTR INST
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