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An electrochemical sensor for detecting glucose and its preparation method

A glucose and electrochemical technology, which is applied in the field of electrochemical electrode material preparation, can solve the problems of complex sample pretreatment, limit further application, consume organic reagents, etc., and achieve the goal of improving electrocatalysis, excellent electrical performance, and improving electrocatalysis ability Effect

Active Publication Date: 2022-03-18
SHANXI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, a variety of methods for the detection of glucose have been proposed. Although these methods exhibit certain advantages, they generally involve disadvantages such as complicated sample pretreatment, long time-consuming, cumbersome operations, consumption of large amounts of organic reagents, and expensive equipment.
These disadvantages greatly limit their further application

Method used

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  • An electrochemical sensor for detecting glucose and its preparation method
  • An electrochemical sensor for detecting glucose and its preparation method
  • An electrochemical sensor for detecting glucose and its preparation method

Examples

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Effect test

Embodiment 1

[0025] Example 1: An electrochemical sensor for detecting glucose, based on cobalt@nickel-metal organic framework-graphene (CNMs-GR) nanocomposite material, the preparation method of the electrochemical sensor is as follows:

[0026] (1) Preparation of cobalt@nickel-metal organic framework: 0.375 mmol of Co(NO 3 ) 2 , 0.375 mmol of Ni(NO 3 ) 2 and 0.75 mmol of 2-aminoterephthalic acid were added to 36 mL of solvent (32 mL of N.N-dimethylformamide, 2 mL of ethanol and 2 mL of secondary water) for sonication. The resulting product was sealed in a reactor and heated at 200 °C for 24 h. Then the reactor was cooled to room temperature, and the solid was collected and washed several times with secondary water. Finally, the resulting solid was dried overnight at 60 °C to obtain cobalt@nickel-MOF powders.

[0027] (2) Preparation of cobalt@nickel-metal-organic framework-graphene: 5.0 mg / mL graphene and 8 mg / mL cobalt@nickel-metal-organic framework were added to water, and 40 KHz ...

Embodiment 2

[0031]Example 2: An electrochemical sensor for detecting glucose, based on cobalt@nickel-metal organic framework-graphene (CNMs-GR) nanocomposite, the preparation method of the electrochemical sensor is: 0.275 mmol of Co(NO 3 ) 2 , 0.275 mmol of Ni(NO 3 ) 2 and 0.55 mmol of 2-aminoterephthalic acid were added to 36 mL of solvent, the concentration of graphene was 3.0 mg / mL, the concentration of cobalt@nickel-metal organic framework was 5 mg / mL, and the amount of dispersion liquid drop-coated on the surface of glassy carbon electrode 5 μL. All the other methods are with the method described in Example 1.

Embodiment 3

[0032] Example 3: An electrochemical sensor for detecting glucose, based on cobalt@nickel-metal organic framework-graphene (CNMs-GR) nanocomposite, the preparation method of the electrochemical sensor is: 0.475 mmol of Co(NO 3 ) 2 , 0.475 mmol of Ni(NO 3 ) 2 and 0.85 mmol of 2-aminoterephthalic acid were added to 36 mL of solvent, the concentration of graphene was 7.0 mg / mL, the concentration of cobalt@nickel-metal organic framework was 10 mg / mL, and the amount of dispersion liquid drop-coated on the surface of glassy carbon electrode 15 μL. All the other methods are with the method described in Example 1.

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Abstract

The invention belongs to the technical field of preparation of electrochemical electrode materials, and provides an electrochemical sensor for detecting glucose and a preparation method thereof. The electrochemical sensor is an electrochemical sensor based on cobalt@nickel-metal organic framework-graphene (CNMs-GR) , the sensor was used to simultaneously detect glucose in human serum. It exhibits high sensitivity and selectivity, the electrode modification process is simpler, and it has good stability and reproducibility. Based on cobalt@nickel‑metal organic framework‑graphene (CNMs‑GR) nanocomposites, bimetallic frameworks were synthesized by a simple hydrothermal reaction to prepare cobalt@nickel‑metal organic framework‑graphene CNMs‑GR nanocomposites. The sensitivity of the electrode is improved and the electrode modification process is simplified. The electrochemical sensor is used to construct a sensing system for detecting glucose in human serum, which significantly improves the selectivity of the electrode. The detection limit is 0.087μmol / L. Wide linear range and high sensitivity.

Description

technical field [0001] The invention belongs to the technical field of preparation of electrochemical electrode materials, and specifically relates to an electrochemical sensor for detecting glucose and a preparation method thereof. The electrochemical sensor is an electrochemical sensor based on cobalt@nickel-metal organic framework-graphene (CNMs-GR). sensor for the simultaneous detection of glucose in human serum. Background technique [0002] Glucose is an essential biomolecule directly involved in metabolic activities in the human body as it produces carbon dioxide and energy (ATP) through oxidation processes. However, high concentrations of glucose in the human blood can cause damage to human health, which can lead to diabetes and other complications. If left unchecked, diabetes can endanger a person's physical condition, causing disability and even death. According to reports, 415 million people face serious diabetes problems, while 193 million people with diabetes ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/327C09D187/00C09D7/61C08G83/00
CPCG01N27/3277G01N27/3278C09D187/00C09D7/61C08G83/008C08L3/04C08L3/02
Inventor 雷鹏周影双少敏董川
Owner SHANXI UNIV
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