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Bioactive glass composite material for wound care and application method thereof

A bioactive glass and composite material technology, applied in the field of wound care and repair materials, can solve the problems of inability to meet the needs of efficient wound care and repair, poor curative effect, long course of treatment, etc., so as to improve the care and repair effect, shorten the time, The effect of promoting proliferation and migration

Inactive Publication Date: 2021-03-19
楚元(湖北)再生医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the present invention provides a bioactive glass composite material for wound care and its application method, which solves the problem of wound care and repair of existing bioactive glass products for wound repair on the market. The treatment period is longer, the curative effect is poor, and it cannot meet the needs of efficient wound care and repair.

Method used

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  • Bioactive glass composite material for wound care and application method thereof
  • Bioactive glass composite material for wound care and application method thereof

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Experimental program
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Effect test

Embodiment 1

[0025] see figure 1 , the present invention provides the following technical solutions: a bioactive glass composite material for wound care, the bioactive glass composite material includes the following raw materials in parts by weight: 75 parts of silk fibroin / gelatin / bioactive glass dispersion liquid, loaded with biological activity 22 parts of chitosan fiber film for glass, 1 part of crosslinking agent, 0.3 part of polypeptide surfactant, and 1.7 parts of sodium hyaluronate.

[0026] Specifically, the mass ratio of silk fibroin, gelatin and bioactive glass in the silk fibroin / gelatin / bioactive glass dispersion is 1:1.5:3.

[0027] Specifically, the mass ratio of bioactive glass to chitosan fiber in the chitosan fiber membrane loaded with bioactive glass is 1:2.

[0028] Specifically, the crosslinking agent is genipin.

[0029] Specifically, the polypeptide surfactant is sodium subtilisin.

[0030] The present invention also provides a method for preparing a bioactive gla...

Embodiment 2

[0038] see figure 1 , the present invention provides the following technical solutions: a bioactive glass composite material for wound care, the bioactive glass composite material includes the following raw materials in parts by weight: 70 parts of silk fibroin / gelatin / bioactive glass dispersion liquid, loaded with biological activity 26 parts of chitosan fiber film for glass, 1.5 parts of crosslinking agent, 0.5 part of polypeptide surfactant, and 2 parts of sodium hyaluronate.

[0039] Specifically, the mass ratio of silk fibroin, gelatin and bioactive glass in the silk fibroin / gelatin / bioactive glass dispersion is 1:2:4.

[0040] Specifically, the mass ratio of bioactive glass to chitosan fiber in the chitosan fiber membrane loaded with bioactive glass is 1:1.

[0041] Specifically, the crosslinking agent is genipin.

[0042] Specifically, the polypeptide surfactant is sodium subtilisin.

[0043] The present invention also provides a method for preparing a bioactive glas...

Embodiment 3

[0051] see figure 1 , the present invention provides the following technical solutions: a bioactive glass composite material for wound care, the bioactive glass composite material includes the following raw materials in parts by weight: 80 parts of silk fibroin / gelatin / bioactive glass dispersion liquid, loaded with biological activity 19 parts of chitosan fiber film for glass, 0.5 part of crosslinking agent, 0.1 part of polypeptide surfactant, and 0.4 part of sodium hyaluronate.

[0052] Specifically, the mass ratio of silk fibroin, gelatin and bioactive glass in the silk fibroin / gelatin / bioactive glass dispersion is 1:2:5.

[0053] Specifically, the mass ratio of bioactive glass to chitosan fiber in the chitosan fiber membrane loaded with bioactive glass is 1:2.

[0054] Specifically, the crosslinking agent is genipin.

[0055] Specifically, the polypeptide surfactant is sodium subtilisin.

[0056] The present invention also provides a method for preparing a bioactive glas...

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Abstract

The invention belongs to the technical field of wound surface care and repair materials, and particularly relates to a bioactive glass composite material for wound care and an application method thereof. The bioactive glass composite material is prepared from the following raw materials in parts by weight: 70-80 parts of fibroin / gelatin / bioactive glass dispersion liquid, 19-26 parts of chitosan fiber membrane loaded with bioactive glass, 0.5-1.5 parts of a cross-linking agent, 0.1-0.5 part of a polypeptide surfactant, and 0.4-2 parts of sodium hyaluronate. The bioactive glass composite material prepared by the invention overcomes the shortcoming and defects of a single material, through integration and process optimization of bioactive glass-loaded chitosan fibrous membrane fragments, fibroin, gelatin and bioactive glass materials, epidermal cell proliferation and migration are effectively promoted, wound repair can be actively participated, regulated and controlled and promoted, compared with the prior art, the wound repair time is shortened to a great extent, and the nursing and repair effects on the wound surface are remarkably improved.

Description

technical field [0001] The invention relates to the technical field of wound care and repair materials, in particular to a bioactive glass composite material for wound care and an application method thereof. Background technique [0002] The research and development and application of bioactive glass originated in the United States, and its main purpose is to develop a drug that can repair both skin and bone tissue. Bioactive glass was first proposed and developed by Professor Hench in 1971. It is currently the only bioactive material that "can repair and bond soft tissue and bone tissue at the same time". Compared with other biological materials, the material has better compatibility and safety. The main functions of bioactive glass are as follows: (1) It can enhance the bactericidal and antibacterial ability of the wound surface; (2) It can promote the dissolution of wound necrotic tissue and fibrinolysis, thereby producing enzyme serum creation; (3) It can create hypoxia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18A61L15/28A61L15/32A61L15/42
CPCA61L15/18A61L15/28A61L15/32A61L15/42C08L89/00C08L89/06C08L5/08
Inventor 范小晴
Owner 楚元(湖北)再生医学科技有限公司