Half-sandwich rhodium complex with ortho-position carborane benzoxazole structure as well as preparation method and application of half-sandwich rhodium complex

A carboryl benzoxazole and rhodium complex technology, which is applied in the preparation of hydroxyl compounds, organic compounds, organic compound/hydride/coordination complex catalysts, etc., can solve the problem of poor yield and selectivity, Low catalytic activity and other problems, to achieve high yield, high catalytic efficiency and high stability
CN112538096AActive Publication Date: 2021-03-23SHANGHAI APPLIED TECHNOLOGIES COLLEGE
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI APPLIED TECHNOLOGIES COLLEGE
Publication Date
2021-03-23

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Abstract

The invention relates to a half-sandwich rhodium complex with an ortho-position carborane benzoxazole structure as well as a preparation method and application of the half-sandwich rhodium complex. The structural formula of the rhodium complex is shown in the specification. The preparation method comprises the following steps: firstly, adding an n-BuLi solution into an ortho-position carborane solution, and then reacting for 30-60 minutes at room temperature; adding bromo-benzoxazole, and carrying out a reaction for 6-8 h at a room temperature; and adding [Cp * RhCl2] 2, reacting at room temperature for 3-5 hours, and carrying out post-treatment to obtain the rhodium complex. The rhodium complex can be used as a catalyst to catalyze the asymmetric reduction reaction of aliphatic chiral alcohol compounds synthesized from aliphatic ketones. Compared with the prior art, the rhodium complex disclosed by the invention has the advantages of simple preparation method, stable physicochemical properties, high catalytic activity for asymmetric reduction reaction of aliphatic ketone, mild reaction conditions and the like.
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Description

technical field

[0001] The invention belongs to the technical field of synthetic chemistry, and relates to a semi-sandwich rhodium complex with an ortho carborane benzoxazole structure and a preparation method and application thereof. Background technique

[0002] Chiral alcohols are a class of high-tech, high value-added products, and as an important intermediate in organic synthesis, they are widely used in the fields of medicine and pesticides. The traditional preparation method of chiral alcohol is obtained from racemic alcohol through multi-stage resolution. This method not only has cumbersome steps, but also consumes a lot of reagents and produces more waste liquid, which has a great impact on the environment. In recent years, in order to meet the requirements of green chemistry, a variety of preparation methods of chiral alcohols have been developed. Among these methods, the preparation method of chiral alcohols synthesized by using catalysts to catalyze the asymmetr...

Claims

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