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Nano-therapeutic structures and methods for their preparation

A technology of nano and therapeutic drugs, applied in the direction of nanotechnology, nanotechnology, nanomedicine, etc., can solve the problems of tumor hypoxia, reduce nano-platform, tumor angiogenesis, etc., and achieve high clinical treatment benefit and efficient clearance effect

Active Publication Date: 2021-12-10
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this drug has the following defects: (1) The medical nano scintillators that play the role of energy conversion are often inefficient, have large toxic and side effects, and cannot exist stably for a long time in physiological environments and retain their optical properties; (2) Nano scintillators The low energy transfer efficiency between the body and the photosensitizer severely restricts the generation of reactive oxygen species, and ultimately reduces the therapeutic effect of the nanoplatform on cancer; (3) X-ray-induced photodynamic therapy will consume oxygen in the tumor microenvironment, resulting in the Tumors in a hypoxic state are extremely hypoxic, which in turn induces a series of adverse prognosis events such as tumor angiogenesis, invasion, and metastasis; (4) Due to the aforementioned limitations, X-ray-induced photodynamic therapy currently reported requires the use of more Large radiation doses to produce sufficient therapeutic effect
On the one hand, the development of new nano scintillators, but the efficiency and biosafety of nano scintillators have not been given sufficient attention; Rational setup of multiple components on nanoplatforms is often overlooked

Method used

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  • Nano-therapeutic structures and methods for their preparation
  • Nano-therapeutic structures and methods for their preparation
  • Nano-therapeutic structures and methods for their preparation

Examples

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Embodiment 1

[0050] Example 1: X-ray photodynamic therapy + chemotherapy

[0051] Lu of the embodiment of the present invention 2 O 3 :Tb 3+ The construction of the nano-scintillator dual-core-satellite structure nanoplatform includes the following steps: Step S1, synthesis of surface carboxyl modified Lu 2 O 3 :Tb 3+ Nano scintillator; step S2, grafting polyethylene glycol on the surface of the dendrimer, and then modifying it to the surface of the nano scintillator; step S3, connecting the photosensitizer Rose Bengal to the surface of the dendrimer; step S4, adding The chemotherapy drug doxorubicin is loaded inside the dendrimer.

[0052] Specifically, the above step S1 includes:

[0053] Step S11: Weigh 0.5 mmol of lutetium acetylacetonate and 0.05 mmol of terbium acetylacetonate into a 50 mL flask, add 15 mL of oleic acid and 5 mL of oleylamine, and stir at 90 °C for 10 min.

[0054] Step S12: heating to 120 °C and vacuuming for 30 min.

[0055] Step S13: pass nitrogen, heat to...

Embodiment 2

[0072] Example 2: X-ray photodynamic therapy + anti-angiogenic therapy

[0073] The CaF of the embodiment of the present invention 2 :Tb 3+ The construction of the nanoscintillator binuclear-satellite nanoplatform includes the following steps: Step P1: Synthesis of surface carboxyl-modified CaF 2 :Tb 3+ Nano scintillator; Step P2: graft the dendrimer with polyethylene glycol on the surface, and then modify it to the surface of the nano scintillator; Step P3: connect the photosensitizer Rose Bengal to the surface of the dendrimer; The angiogenesis drug Sunitinib is loaded inside the dendrimer.

[0074] Specifically, the above step P1 includes:

[0075] Step P11: Weigh 0.5 mmol of calcium chloride, 0.05 mmol of terbium chloride, and 0.5 mmol of sodium citrate, dissolve them in 25 mL of deionized water, and fully stir for 30 min to form a stable combination of citrate and metal cations.

[0076] Step P12: Weigh 3.0 mmol of ammonium fluoride, dissolve it in 5 mL of deionized ...

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Abstract

The present invention provides a nano therapeutic structure and a preparation method thereof. The structure comprises: a nano scintillator, the surface of the nano scintillator is modified with a dendrimer, and a photosensitizer is grafted on the surface of the dendrimer, and the A cavity for loading therapeutic drugs is provided inside the dendrimer. The nano-therapeutic structure in the present invention has the ability to load multiple drugs, and can be used as a universal template to build a collaborative treatment platform for X-ray photodynamic therapy and other therapies, such as: X-ray photodynamic therapy + radiotherapy, X-ray photodynamic therapy Therapy + chemotherapy, X-ray photodynamic therapy + immunotherapy, X-ray photodynamic therapy + anti-angiogenesis therapy have extremely high clinical therapeutic benefits, and can achieve efficient removal of deep tumors under low-dose conditions.

Description

technical field [0001] The present invention relates to the technical field of nanomaterials, in particular, to a nanometer therapeutic structure and a preparation method thereof. Background technique [0002] Developing effective treatments to combat cancer remains one of the top priorities of modern clinical medicine. X-ray-induced photodynamic therapy utilizes nanoscintillators to convert X-rays into ultraviolet or visible light, which then excite the photosensitizer and trigger the production of reactive oxygen species, which can kill cancer cells. Due to the extremely high penetration depth of X-rays in biological tissues, X-ray-induced photodynamic therapy has great potential for the treatment of deep cancers. [0003] After searching the prior art, the application number is: CN201780031000.X, which discloses a prodrug of a lipid moiety linked to a drug derivative such as an anticancer drug derivative through a linker comprising a disulfide group, and a prodrug coated...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K45/00A61K47/58A61K47/59A61K47/61A61K47/64A61P35/00B82Y5/00
CPCA61K41/0057A61K45/00A61K47/595A61K47/58A61K47/64A61K47/61A61P35/00B82Y5/00A61K2300/00
Inventor 李万万姜朝
Owner SHANGHAI JIAO TONG UNIV