Preparation method of 1-chlorobutane

Abstract

The invention belongs to the technical field of fine chemical engineering, and particularly relates to a preparation method of 1-chlorobutane. A reaction solvent, water and n-butyl alcohol are mixed, and a chlorination reagent is added for reaction to obtain 1-chlorobutane, wherein the reaction solvent is 2, 3, 5, 6-tetramethyl dioxane. A one-pot method is adopted, and the method is simple, good in safety, easy to implement, low in equipment requirement and capable of realizing continuous production. The problem of heavy pollution of the traditional metal catalyst is avoided, three wastes are few, and the method is environment-friendly. 2, 3, 5, 6-tetramethyl dioxane is used as a reaction solvent and a catalyst, so that the generation of byproducts such as butene, dibutyl ether and polymer resin can be effectively avoided, the yield and the product quality are improved, the molar yield of the product is 96% or above, and the gas phase purity is 99.7% or above.

Description

technical field

[0001] The invention belongs to the technical field of fine chemicals, and in particular relates to a preparation method of 1-chlorobutane. Background technique

[0002] 1-Chlorobutane is an important fine chemical product, which can be used in oils and fats, rubber, natural resin solvents, pharmaceutical intermediates, co-catalysts, etc. At present, it is mainly used to prepare butyllithium, an olefin polymerization catalyst, to prepare butyltin products through Grignard reaction, to prepare phenylbutazone in medicine, to prepare the insecticide myclobutanil in pesticides, and to produce polyether. Used as a solvent. At present, more than 99% of products are required in the market, and the purity of 1-chlorobutane used for synthesizing n-butyllithium is required to be ≥99.5%.

[0003] The prior art mainly uses n-butanol and hydrochloric acid or hydrogen chloride gas as raw materials to synthesize 1-chlorobutane, and the main synthetic methods are as follow...

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