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Aggregation-induced emission polymer nanoparticles as well as preparation method and application thereof

A technology of aggregation-induced luminescence and nano-particles, which is applied in nanotechnology, nanotechnology, nano-optics, etc., can solve the problems of low synthesis efficiency and achieve the effects of simple operation, good uniformity and improved stability

Active Publication Date: 2021-04-27
广东省大湾区华南理工大学聚集诱导发光高等研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The AIE polymer nanoparticles prepared by the self-assembly method [Chem.Commun 2010,46,1377–1393.] and the nanoprecipitation method [J Mater Chem,2009,19,3838–3840.] need to be carried out at a lower concentration. low efficiency

Method used

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  • Aggregation-induced emission polymer nanoparticles as well as preparation method and application thereof
  • Aggregation-induced emission polymer nanoparticles as well as preparation method and application thereof
  • Aggregation-induced emission polymer nanoparticles as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Weigh 0.05 g of sodium lauryl sulfate, dissolve it in 12.5 g of water, and use it as an aqueous emulsifier solution for the continuous phase.

[0045] Dissolve 0.001 g of AIE-14 molecule, 0.06 g of n-hexadecane, and 0.1 g of polymethyl methacrylate in 4 mL of dichloromethane solvent as an oily solution of the dispersed phase. The two solutions were mixed and pre-emulsified in a water bath for 15 min under magnetic stirring at 700 rpm to obtain a coarse emulsion. The coarse emulsion was ultrasonicated for 10 min in an ice-water bath, the ultrasonic power was 400 W, and the pulse sequence was 12 s on, 6 s in interval to obtain stable fine emulsion droplets. Put the AIE polymer nanoparticle emulsion into a rotary evaporator, remove the solvent solvent under a low-pressure environment, and obtain the AIE polymer nanoparticle emulsion. The emulsion was centrifuged, and then redispersed in water, and this method was circulated three times to obtain purified AIE polymer nanop...

Embodiment 2

[0048] Weigh 0.2 g of cetyltrimethylammonium chloride, dissolve it in 50 g of water, and use it as the aqueous emulsifier solution of the continuous phase.

[0049] 0.004 g of AIE-18 molecule, 0.04 g of n-hexadecane, and 0.4 g of poly(lactic-co-glycolic acid) were dissolved in 16 mL of ethyl acetate solvent as an oily solution of the dispersed phase. The two solutions were mixed and pre-emulsified in a water bath for 15 min under magnetic stirring at 700 rpm to obtain a coarse emulsion. The coarse emulsion was ultrasonicated for 8 minutes in an ice-water bath, the ultrasonic power was 450W, and the pulse sequence was 12s working and 6s interval to obtain stable fine emulsion droplets. Put the AIE polymer nanoparticle emulsion into a rotary evaporator, remove the solvent solvent under a low-pressure environment, and obtain the AIE polymer nanoparticle emulsion. The emulsion was centrifuged, and then redispersed in water, and this method was circulated three times to obtain pur...

Embodiment 3

[0052] Weigh 2 g of polyvinyl alcohol, dissolve it in 100 g of water, and use it as the emulsifier aqueous solution of the continuous phase.

[0053] 0.008 g of AIE-6 molecules, 0.08 g of n-hexadecane, and 0.8 g of phospholipid polyethylene glycol maleimide were dissolved in 30 mL of chloroform solvent as an oily solution of the dispersed phase. The two solutions were mixed and pre-emulsified in a water bath for 15 min under magnetic stirring at 700 rpm to obtain a coarse emulsion. The coarse emulsion was ultrasonicated for 6 minutes in an ice-water bath, the ultrasonic power was 500W, and the pulse sequence was 12s working and 6s interval to obtain stable fine emulsion droplets. Put the AIE polymer nanoparticle emulsion into a rotary evaporator, remove the solvent solvent under a low-pressure environment, and obtain the AIE polymer nanoparticle emulsion. The emulsion was centrifuged, and then redispersed in water, and this method was circulated three times to obtain purified...

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Abstract

The invention discloses aggregation-induced emission polymer nanoparticles as well as a preparation method and application thereof, and the preparation method comprises the following steps: (1) dissolving an emulsifier in deionized water to obtain a water-phase solution; (2) dissolving AIE molecules, a co-stabilizer and a polymer in a solvent which is immiscible with water to obtain an oil phase solution; and (3) adding the aqueous solution prepared in the step (1) into the oil phase solution prepared in the step (2), mixing and stirring for pre-emulsification to obtain a crude emulsion; carrying out ultrasonic treatment to prepare miniemulsion droplets; removing the volatile solvent under a reduced pressure condition to obtain an AIE polymer nanoparticle emulsion; and purifying to obtain the AIE polymer nanoparticles. According to the invention, the particle size of the AIE polymer nanoparticles can be regulated and controlled by changing the type and content of the surfactant; meanwhile, the luminescence color and fluorescence intensity of the AIE polymer nanoparticles can be simply and conveniently regulated and controlled through the type and dosage of AIE molecules.

Description

technical field [0001] The invention relates to an aggregation-induced luminescence material, in particular to an aggregation-induced luminescence polymer nanoparticle and a preparation method and application thereof. Background technique [0002] Fluorescent polymer nanoparticles refer to the introduction of fluorescent molecules into polymer nanoparticles by covalent or embedding methods. They are an important class of functional nanomaterials with good stability, high photostability, adjustable particle size and surface It can be modified and other characteristics, and has important practical application value in many fields such as anti-counterfeiting materials, in vitro diagnosis and cell imaging. Traditional ACQ molecules emit strong fluorescence in dilute solution state, and the fluorescence weakens in high concentration or aggregation state, which makes traditional fluorescent polymer nanoparticles often have defects such as low fluorescence quantum yield and complex...

Claims

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Application Information

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IPC IPC(8): C09K11/02C07D307/68C07D235/02C07C255/37C07D409/10C07F5/02C07D285/14C07D495/04C09K11/06B82Y20/00B82Y30/00B82Y40/00G01N21/64
CPCC09K11/02C07D307/68C07D235/02C07C255/37C07D409/10C07F5/02C07D285/14C07D495/04C09K11/06B82Y20/00B82Y30/00B82Y40/00G01N21/6428C09K2211/1007C09K2211/1088C09K2211/1044C09K2211/1014C09K2211/1029C09K2211/1092C09K2211/1055C09K2211/1051C09K2211/1096
Inventor 唐本忠胡亚新王志明刘勇
Owner 广东省大湾区华南理工大学聚集诱导发光高等研究院
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