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Lamellar calcium diphosphonate complex and preparation method thereof

A calcium bisphosphonate, flake-like technology, applied in the field of biomedical materials, can solve problems such as adverse reactions and low concentration threshold, and achieve the effects of good uniformity, moderate crystal growth rate and simple preparation method

Inactive Publication Date: 2021-04-30
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current bisphosphonic acid (or sodium salt) is relatively water-soluble, and the concentration threshold for its effective effect is very low, and it is easy to cause adverse reactions if it exceeds the threshold, so it can only be directly injected or loaded with a delivery system for sustained release. To some extent, it limits the application of bisphosphonates, which have significant osteogenic effects, in bone regeneration and repair.

Method used

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  • Lamellar calcium diphosphonate complex and preparation method thereof
  • Lamellar calcium diphosphonate complex and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0018] Weigh 1-hydroxyl-2-(imidazol-1-yl)-ethylene-1,1-diphosphoric acid (0.0272g, 0.10mmol) with a purity of 98%, calcium chloride (0.0110g , 0.10mmol), add 10mL water, slowly drop into 0.1mol / L hydrochloric acid solution, stir at the same time to make the solution clear and transparent and adjust the pH to 1.5, then transfer the solution to a vial, cover it, tighten it, and place the vial in In a thermostat, react at 20°C for 72 hours, then filter, wash, and dry to obtain large, regular-shaped colorless transparent flaky crystals, which are flaky calcium bisphosphonate complexes. Among them, the reaction time of the preparation process is negatively correlated with the reaction temperature, that is, the higher the temperature, the shorter the reaction time; As the pH increases, the size becomes smaller and smaller.

[0019] figure 1 It is a scanning electron microscope picture of a thin-flaky calcium bisphosphonate complex crystal, and it can be seen from the figure that t...

Embodiment 2

[0022] Weigh 1-hydroxyl-2-(imidazol-1-yl)-ethylene-1,1-diphosphoric acid (0.0408g, 0.15mmol) with a purity of 98%, calcium hydroxide (0.0074g , 0.1mmol), add 10mL water, slowly drop into 0.1mol / L hydrochloric acid solution, stir at the same time to make the solution clear and transparent and adjust the pH to 1.5, then transfer the solution to a vial, cover it, tighten it, and place the vial in In a thermostat, react at 50°C for 60 hours, then filter, wash, and dry to obtain large, regular-shaped colorless transparent flaky crystals, which are flaky calcium bisphosphonate complexes.

Embodiment 3

[0024] Weigh 1-hydroxyl-2-(imidazol-1-yl)-ethylene-1,1-diphosphoric acid (0.0544g, 0.20mmol) with a purity of 98%, calcium nitrate (0.0164g, 0.10mmol), add 10mL water, slowly drop into 0.1mol / L hydrochloric acid solution, stir at the same time to make the solution clear and transparent and adjust the pH to 2, then transfer the solution to the reaction kettle, cover it, tighten it, and place the reaction kettle at a constant temperature In the oven, react at 100°C for 48 hours, then filter, wash, and dry to obtain moderate, colorless, transparent flaky crystals with regular shapes, which are flaky calcium bisphosphonate complexes.

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PUM

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Abstract

The invention discloses a lamellar calcium bisphosphonate complex and a preparation method thereof, the chemical formula of the lamellar calcium bisphosphonate complex is Ca (Zol) 2.3 H2O, Ca represents calcium, Zol represents 1-hydroxy-2-(imidazole-1-yl)-ethylidene-1, 1-diphosphoric acid, H2O represents water, the crystal system is an orthorhombic crystal system, the space group is PBCA, and the lattice constant is z = 8. The preparation method comprises the following steps: by taking calcium salt and 1-hydroxy-2-(imidazole-1-yl)-ethylidene-1, 1-diphosphoric acid as raw materials and deionized water as a solvent, adjusting the pH value to 1.5-2.5 by using a sodium hydroxide or hydrochloric acid solution, standing at 20-200 DEG C for 24-72 hours, filtering, washing and drying to obtain a flaky transparent crystal, namely the lamellar calcium bisphosphonate complex. The lamellar calcium bisphosphonate complex is extremely simple in preparation method, moderate in crystal growth speed, small in stress, good in uniformity and very complete in appearance, and has important potential application prospects in the fields of drug sustained release, targeted delivery, bone tissue repair and the like.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a flaky bisphosphonate calcium complex and a preparation method thereof. Background technique [0002] Coordination polymers are a class of compounds formed by the combination of metal ions and organic ligands through coordination bonds. In recent years, the development of coordination polymer chemistry has endowed it with new explorations and applications in the fields of design, synthesis, structure, and performance, and has gradually become a frontier and hot topic in organic, inorganic, materials, biology, and medical disciplines. Using the principle of molecular self-assembly to design and construct complexes with novel structures, so that they have specific biological functions, has important practical significance for their wide application in the field of biomedicine. [0003] 1-Hydroxy-2-(imidazol-1-yl)-ethylene-1,1-diphosphate is a bisphosphonic acid widel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/6506
CPCC07F9/6506C07B2200/13
Inventor 施雪涛壮琛柴牧原林佳义杨夕冉
Owner SOUTH CHINA UNIV OF TECH
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