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Medical hyaluronic acid hydrogel dressing containing chlorogenic acid and paeoniflorin
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A technology of hyaluronic acid and sodium hyaluronate, which is applied in the field of biomedical materials and can solve problems such as limited effects
Inactive Publication Date: 2021-05-14
JILIN UNIV
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Problems solved by technology
Surgical debridement, antibiotics and wound dressings remain the mainstays of wound care, but most of these are one-dimensional and have limited effectiveness
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Embodiment 1
[0038] refer to Figure 1-7 , a hyaluronic acid hydrogel medical dressing containing chlorogenic acid and paeoniflorin, comprising the steps of:
[0039] S1 selects 20ml of deionized water, and then dissolves 0.5g of sodium hyaluronate in 20ml of deionized water;
[0040] S2 Stir the deionized water and sodium hyaluronate evenly, then add 3g of adipic acid dihydrazide, and then, stir overnight to obtain a mixed solution;
[0041] S3 adjust the pH value of the mixed solution to 4.7 with HCl, add 0.4 g of carbodiimidehydrochloride, and stir well, so that the solution gradually becomes a gel;
[0042] S4 washes the gel 3 times in an ultrasonic cleaner with dehydrated ethanol, and then washes the gel 3 times in an ultrasonic cleaner with PBS;
[0043] S5 freezes the cleaned gel, freezes it and freezes it in a freeze-vacuum dryer to make a dry gel block for later use;
[0044] S6 measures the swelling rate of the dried gel piece;
[0063] To prepare hyaluronic acid hydrogel, add 0.2 g of sodium hyaluronate (1800-2200 kDa) to 20 ml of deionized water, stir well, add 1.4 g of adipate dihydrazide, and stir overnight; adjust the pH value to 4.7 with HCl, Add 0.4 g of carbodiimidehydrochloride, stir well, and the solution gradually becomes a gel; wash the gel with deionized water in an ultrasonic cleaner, adjust the pH value to 7 with NaOH, and pre-cool in a -20°C refrigerator ; Freeze-dried in a freeze-vacuum drying apparatus, placed in a vacuum dryer for standby, and prepared into 8% hydrogel with deionized water during use.
Embodiment 3
[0065] For cell viability detection, adjust the cell density to 2×104 cells / mL, add 100 μL to each well except the edge of the 96-well plate, so that the number of cells in each well is 2000, mix well by cross oscillating, add 200 μL medium to the edge well; Cultivate overnight in the incubator, and when the cells are adhered to the wall for administration, discard the wells inoculated with cells in the 96-well plate, and add the 1640 complete medium solution concentration to the wells in order from small to large, 180 μL per well (set 5 secondary wells as a group, Each discarded group was added with a concentration gradientdrug), the control group was added with 180 μL of 1640 medium containing 10% FBS, and the blank group was added with 50 μL of DMSO, and cultured in an incubator for 24 hours. . Add 20 μL of MTT solution to each well of the administration group, control group, and blank group, and tap the bottom of the plate to make the droplets on the wall fall into the bot...
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technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a hyaluronic acid hydrogel medical dressing containing chlorogenic acid and paeoniflorin. Background technique [0002] The skin can protect the body from external damage, sense environmental changes, and maintain physiological balance, but it is also extremely vulnerable to damage. Certain physiological states (eg, age, infection, and severe injury) or underlying medical conditions (eg, ischemia, diabetes, and obesity) interfere with wound healing. Skin repair and regeneration associated with surgical trauma, acute trauma, and chronic disease are central issues in healthcare. Annual Medicare costs for wound care are estimated to range from $28.1 billion to $96.8 billion, placing a severe burden on healthcare systems worldwide. It is worth noting that chronic trauma is often accompanied by complications such as inflammation, cellular dysfunction, and angiogenesis d...
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