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Ultrasonic contrast medium and its preparing process

A technology of ultrasound contrast agent and volume, applied in the direction of echo/ultrasound imaging agent, etc., can solve the problems that it is difficult to achieve peripheral tissue or organ enhancement, microbubbles cannot effectively pass through the pulmonary circulation, and the diameter of microbubbles is large, so as to achieve strong blood flow and Tissue enhancement effect, convenient preparation, and long-term stable effect

Inactive Publication Date: 2003-11-26
GENERAL HOSPITAL OF PLA
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

The reason for this is that the diameter of the microbubbles in the previously developed ultrasound contrast agent is large (>10 μm) and the stability is poor, so that the microbubbles cannot effectively pass through the pulmonary circulation. To achieve ultrasound contrast, direct injection of contrast through an arterial cannula is often used. It can only be used to visualize the cardiac chambers (excluding gastrointestinal contrast-enhanced ultrasonography with oral contrast agents), so it is difficult to achieve the enhancement of peripheral tissues or organs, which limits the application of ultrasonic contrast agents in the diagnosis of systemic diseases

Method used

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  • Ultrasonic contrast medium and its preparing process
  • Ultrasonic contrast medium and its preparing process
  • Ultrasonic contrast medium and its preparing process

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Experimental program
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Effect test

Embodiment 1

[0043] General Secretary 80 : Oleic acid: Tween 80 (S:O:T) were prepared according to the volume ratio of 3:1:1; 5:1:1; 7:1:1; Perfluoropropane gas, the ultrasonic contrast agent of the present invention is prepared according to the steps of the preparation method. Among them, a W-385 vibroacoustic instrument (Heat systems Inc. USA) was used, with a vibratory acoustic frequency of 20KHz, a power level of 9, and an oscillation time of 40 seconds. The relationship between the microbubble concentration and the size of the ultrasound contrast agent prepared in this way is shown in Table 1.

[0044] Table 1 Microbubble concentration and microbubble size under optimal conditions S:O:T Average number of microbubbles (10 8 / ml) Standard Deviation Average Microbubble Diameter (μm) Standard Deviation (μm) 3∶1∶1 10.45 1.65 2.95 0.415∶1∶1 12.65 1.65 2.57 0.047∶1 12.87 1.41 2.39 0.0810∶1∶1 12.87 0.47 2.88 0.45

[0045] It can be seen from Table 1 that there is no significa...

Embodiment 2

[0049] use his class 80 : Oleic acid: Tween 80 =5:1:1 ultrasound contrast agent of the present invention was used for in vitro experiments.

[0050] Connect the silicone tube filled with normal saline to the blood flow pump, turn the blood flow pump, the liquid in the silicone tube flows like an artery, the flow rate is about 100ml / min, fix part of the silicone tube in the water tank, the high frequency probe is 7-10MHz, Display the color Doppler signal of the fluid in it, inject 1ml of this contrast agent into the silicone tube, record the real-time video, the signal is collected by computer and digitally processed to analyze the degree and time of Doppler signal enhancement, the results are shown in Table 2 .

[0051] Table 2 In vitro measurement results of this ultrasound contrast agent

[0052] After contrast Blood flow signal intensity before contrast ++ + Blood flow signal saturation +++ ++ Blood flow signal continuity ++ +

[005...

Embodiment 3

[0057] use his class 80 : Oleic acid: Tween 80 =5:1:1 ultrasound contrast agent of the present invention was used for in vivo experiments.

[0058] After the New Zealand white rabbits were routinely anesthetized, 0.1ml / kg of the contrast agent was injected through the ear vein at a uniform speed for about 20 seconds. High-frequency probes display rabbit liver, kidney, large blood vessels and other tissues and organs, real-time video recording, and converted into digital signals by computer, quantitative analysis of blood flow and tissue echo before and after contrast. Results: The blood flow signals of the parenchymal organs such as liver, kidney and spleen in white rabbits increased and enhanced obviously. Compared with other contrast agents as shown in Table 3, Table 4, image 3 with Figure 4 shown

[0059] Table 3 Comparison between this ultrasound contrast agent (S:O:T=5:1:1) and German Levovist

[0060] Levovist SOT

[0061] ...

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Abstract

An ultrasonic contract medium is prepared through stirring the mixture of span-80, oleic acid, Tween-80 and 6% dextran injection, inserting the vibrating probe of acoustic vibrator into the liquid tomake it oscillate while the fluorocarbon gas is fed in it from bottom, laying aside, taking microbulles suspension, loading in bottles, sealing and low-temp storage. Its advantages are simple preparing process and high effect.

Description

technical field [0001] The invention relates to a contrast agent for ultrasonic diagnosis, in particular to an oleic acid ester ultrasonic contrast agent containing fluorocarbon gas and a preparation method thereof. Background technique [0002] In many medical imaging clinical diagnosis, contrast technology is an important supplementary means to improve diagnosis, such as CT, MRI examination, injection of contrast agent can effectively identify different manifestations of human tissues and lesions. In these medical image contrast techniques, the cost of contrast examination is often relatively expensive. [0003] Injecting substances (ultrasound contrast agents) with different acoustic properties from those of human tissues into the human body to achieve enhanced blood flow and tissue echoes in ultrasound examinations is called contrast-enhanced ultrasound. The development and clinical application of ultrasound contrast agents will become one of the important trends in the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/22
Inventor 唐杰罗渝昆张彦
Owner GENERAL HOSPITAL OF PLA
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