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an implant

A technology of implants and cells, which is applied in the field of implants, can solve the problems of good surface softness, and achieve the effect of facilitating tissue regeneration, good cell adhesion ability, and promoting regeneration

Active Publication Date: 2021-08-27
GUANGZHOU SUN SHING BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to provide an implant for the treatment of pelvic floor diseases. When it adopts different shapes, it can be used for the treatment of urinary incontinence or pelvic floor organ prolapse, which solves the problem of high stability and cell adhesion. In addition to the growth environment, it is also necessary to have a good surface softness

Method used

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Effect test

Embodiment 1

[0059] Embodiment 1: An implant is composed of a cell adhesion layer 1 and a skeleton regeneration layer 2. The preparation method used for the cell adhesion layer 1 and the skeleton regeneration layer 2 is electrospinning, and what is prepared is: a cross-porous mesh structure, the fiber diameter of the network is 15±3um, and the stress is 486±3MPa; the skeleton regeneration layer 2 is a dense three-dimensional porous structure skeleton, in which extracellular matrix particles 3 are randomly distributed; the cell adhesion layer 1 and the skeleton regeneration The layer 2 is prepared separately, and the cell adhesion layer 1 completely wraps around the skeleton regeneration layer 2 to form the final implant. Its cross-sectional diagram is shown in the appendix figure 1 . When used as a urethral sling, it is processed into a long strip; when used as a pelvic floor organ sling, it is processed into a butterfly shape. The specific process is: according to the mass fraction, add...

Embodiment 2

[0060] Example 2: An implant, one side is a cell adhesion layer 1, and the other side is a skeleton regeneration layer 2, which is prepared by continuous electrospinning. What is prepared is: sandwich structure, the first layer is cross-porous The network structure, the fiber diameter of the network is 15±3um, the stress is 486±3MPa; the second layer is also a cross-porous network structure, and the angle between it and the fibers of the first layer is 45°, and the fiber diameter of the network is 47±6um, the stress is 348±2MPa; the third layer of skeleton regeneration layer 2 is a layer of dense three-dimensional porous structure skeleton, in which extracellular matrix particles 3 are randomly distributed; the three-layer structure is integrally spun and formed, and its cross-sectional diagram is shown in attached figure 2 . The specific preparation process is: according to the mass fraction, add 60% silk fibroin, add 20% extracellular matrix, and perform dry spinning with ...

Embodiment 3

[0061] Embodiment 3: An implant is integrally processed. The difference from Embodiment 2 is that the guided regeneration of cells is considered. In the skeleton regeneration layer 2, the concentration of the extracellular matrix is ​​distributed in a gradient. According to the mass fraction, add 60% silk fibroin, add 20% extracellular matrix, dry spinning with water as a solvent to obtain a thin fiber layer, the fiber diameter of the thin fiber layer is between 15±3um, which is cross-network Structure; according to the mass fraction, add 20% silk fibroin, add 35% extracellular matrix, use water as a solvent, and use ammonium sulfate aqueous solution as a coagulation bath to carry out wet spinning on the basis of the thin fiber layer to obtain The thick fiber layer, the fiber diameter of the thick fiber layer is between 47 ± 6um, which is a cross network structure; according to the mass fraction, 70% poly-L-lactic acid and 20% extracellular matrix are dissolved in a solvent for...

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Abstract

The purpose of the present invention is to provide an implant for the treatment of pelvic floor diseases. When it adopts different shapes, it can be used for the treatment of urinary incontinence or pelvic floor organ prolapse, which solves the problem of high stability and cell adhesion. Adhering to the growth environment and having a good surface softness, an implant is used for the treatment of pelvic diseases, the implant includes: a cell adhesion layer, a membrane composed of at least one layer of cross-network porous structure , its fiber diameter is between 5um-80um, and the stress is between 545MPa-201MPa; the skeleton regeneration layer includes at least one layer of dense degradable three-dimensional porous structure skeleton, and an extracellular matrix on the skeleton, the extracellular The way of adding the matrix includes adding particles and / or adding solutions; the way of connecting the cell adhesion layer and the skeleton regeneration layer includes: wrapping, pressing, integrally forming, and gluing; the implant is a suspension of pelvic floor organs. belt, urethral sling.

Description

technical field [0001] The invention relates to the technical field of implants, in particular to implants for pelvic floor treatment. Background technique [0002] People with frequent pelvic floor diseases are postpartum people and middle-aged and elderly people, and the incidence rate of middle-aged and elderly women is much higher than that of middle-aged and elderly men. [0003] Urinary incontinence (UI) and pelvic floor organ prolapse (POP) are the two types of pelvic floor diseases that have been studied more. Urinary incontinence is characterized by the loss or reduction of the ability to maintain the closure of the urethral sphincter when the bladder is full of urine. Urinary incontinence plays an important role in social activities and health care. All aspects are serious problems. [0004] Stress urinary incontinence SUI is a type of urinary incontinence with the highest incidence. Stress incontinence is defined as the voiding of less than 50 ml of urine due to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/00
CPCA61F2/0045A61F2240/00
Inventor 郑浩翔张雅洁吴松程继文曾晨光
Owner GUANGZHOU SUN SHING BIOTECH CO LTD
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