The invention relates to the technical field of thermoplastic bone fixing plates and strings, particularly to a polyurethane thermoplastic bone fixing plate and a preparation method thereof. The polyurethane thermoplastic bone fixing plate is made from,, by part, 40-80 parts of polyurethane plastic particles, 10-50 parts of engineering plastics, 0-30 parts of soft modified materials, 0-10 parts of fillers and 0.1-2 parts of antioxygen. The polyurethane thermoplastic bone fixing plate is made of medical polymer materials with high supporting performance and accordingly is dismountable, reusable and plastic, meanwhile, can obtain good adhesiveness and provide supporting and fixing effects according to the detailed shapes of different wounded positions, is breathable, sweat-proof and capable of avoiding side effects such as skin irritation and allergy, also, is recyclable, naturally degradable and environmentally friendly, and when replacing traditional gypsum materials for clinical orthopedic exterior fixation, can greatly improve the living conditions for rehabilitation of a patient. The preparation method of the polyurethane thermoplastic bone fixing plate is simple, mature, high in production efficiency and applicable to generalized popularization and application.