Preparation method of nitrated graphene oxide

A graphene, nitration technology, applied in chemical instruments and methods, inorganic chemistry, carbon compounds, etc., to achieve the effects of good dispersion, low cytotoxicity, and strong antibacterial ability

Pending Publication Date: 2021-06-25
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although researchers have done a lot of research on the antibacterial

Method used

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  • Preparation method of nitrated graphene oxide
  • Preparation method of nitrated graphene oxide
  • Preparation method of nitrated graphene oxide

Examples

Experimental program
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Effect test

Example Embodiment

[0020] Example 1

[0021] (1) Preparation of Go

[0022] 1 take 24 ml thick h 2 SO 4 Add 100 mL beaker, heating the oil bath to 80 ° C, sequentially add K 2 S 2 O 8 P 2 O 5 Each 5 g, stir even, then add graphite powder 6g, pre-oxidation 4.5 h. After the end of the reaction, 1000 mL of deionized water was added, and 12 h was allowed to stand at 12 h, discarded, and filtered to dryness, dried at 60 ° C for 24 h.

[0023] 2 Add the above-mentioned dry stone toner to 240 ml of cold concentration H 2 SO 4 In the middle, stir even after adding KMNO 4 Powder 30 g, place the beaker in the ice water bath, keep this step of the reaction system temperature at 20 ° C, to KMNO 4 completely dissolved.

[0024] 3 The mixture temperature was raised to 35 ° C and stirred 2 h, and the reaction was continued to the reaction system to continue to be added to 2 h. The addition of 1.4 L deionized water and 40 ml concentration of 30% 2 O 2 To get brownish yellow aqueous solution.

[0025] 4 The brown-ye...

Example Embodiment

[0032] Example 2

[0033] (1) Preparation of GO: To, in Example 1;

[0034] (2) Preparation of Nitrosyl Oxide (NGO)

[0035] 1 The above GO was added to deionized water to give a concentration of 1 to 3 mg / mlGO dispersion;

[0036] 2 Take 80 ml of concentration of 2 mg / ml of GO, and concentrated nitric acid (WT ≥ 65%) 20 mL while gently stirring, continuously stirring 10 to 30 min, so that it is mixed well;

[0037] 3 Transferred the reaction solution to a high pressure reaction kettle of 100 mL of stainless steel TEFLON lining, and closed reaction 20 h under high temperature conditions at 150 ° C;

[0038] 4 After the reaction, the cooled reaction solution was transferred to a 250 mL beaker, and the water bath was heated 60 to 80 ° C, and the resulting brown yellow powder was NgO.

[0039] NGO bactericidal properties: NGO of 30 μg / mL to Escherichia coli (10 7 CFU / mL) of 91.26% of the sterilization rate, golden staphylococcus aureus (10 7 The bactericidal ratio of CFU / mL...

Example Embodiment

[0040] Example 3

[0041] (1) Preparation of GO: To, in Example 1;

[0042] (2) Preparation of Nitrosyl Oxide (NGO)

[0043] 1 The above GO was added to deionized water to give a concentration of 1 to 3 mg / mlGO dispersion;

[0044] 2 Take 70 ml of concentration of 3 mg / ml of GO, and concentrated nitric acid (WT ≥ 65%) 30 mL while gently stirring, continuously stirring for 10 to 30 min, so that it is mixed well;

[0045] 3 Transferred the reaction mixture to 100 mL of stainless steel TEFLON lining high pressure reactor, and closed reaction under high temperature conditions at 180 ° C;

[0046] 4 After the reaction, the cooled reaction solution was transferred to a 250 mL beaker, 60 ° C - 80 ° C water bath was heated to dry, and the resulting brownish yellow powder was NGO.

[0047] NGO bactericidal properties: NGO of 30 μg / mL to Escherichia coli (10 7 CFU / mL) of 55.32%, for golden staphylococcus aureus (10 7 The bactericidal ratio of CFU / mL is 70.81%.

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Abstract

The invention discloses a preparation method of nitrated graphene oxide, which comprises the following steps: adding graphene oxide into deionized water to obtain a graphene oxide dispersion liquid with the concentration of 1-3mg/mL, then adding concentrated nitric acid, uniformly stirring and mixing, carrying out hydrothermal reaction at 120-180 DEG C for 10-20 hours, and after the reaction is finished, heating in a water bath and evaporating to dryness to obtain brown yellow powder, namely nitrated graphene oxide NGO. The nitrated graphene oxide is simple in preparation method, good in water dispersion performance, high in oxidation degree and good in cell compatibility, the antibacterial performance on gram-positive bacteria and gram-negative bacteria is remarkably improved, and the nitrated graphene oxide can serve as a novel efficient antibacterial material to be used in the fields of biomedicine and the like.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method of nitrated graphene oxide. Background technique [0002] Pathogenic bacteria are one of the greatest threats to human health, causing millions of infections each year. Since the discovery of penicillin in 1928, various antibiotics such as chloramphenicol, erythromycin, and streptomycin have been discovered and used in medicine to treat infections caused by various bacteria. However, with the widespread use of antibiotics, bacteria will gradually change their physiological or metabolic pathways to resist the effects of antibiotics and eventually evolve into drug-resistant bacteria. Nowadays, with the continuous emergence, abuse and long-term use of various antibiotics, the drug resistance of various bacteria, especially animal pathogens, is also increasing, and even multi-drug resistant bacteria that can resist multiple antibiotics appear, whi...

Claims

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Application Information

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IPC IPC(8): C01B32/198
CPCC01B32/198
Inventor 张继宋珅丁玲刘小媛黄玉龙杨生荣范增杰
Owner NORTHWEST NORMAL UNIVERSITY
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