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Preparation method of nitrated graphene oxide

A graphene, nitration technology, applied in chemical instruments and methods, inorganic chemistry, carbon compounds, etc., to achieve the effects of good dispersion, low cytotoxicity, and strong antibacterial ability

Pending Publication Date: 2021-06-25
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although researchers have done a lot of research on the antibacterial properties of graphene, the results of the research are still controversial.

Method used

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  • Preparation method of nitrated graphene oxide
  • Preparation method of nitrated graphene oxide
  • Preparation method of nitrated graphene oxide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Preparation of GO

[0022] ① Take 24 mL concentrated H 2 SO 4 into a 100 mL beaker, heated in an oil bath to 80°C, and added K 2 S 2 o 8 and P 2 o 5 5g each, stir evenly, then add 6g of graphite powder, pre-oxidize for 4.5 h. After the reaction was completed, 1000 mL of deionized water was added to the above mixture and allowed to stand for 12 h, the supernatant was discarded, the precipitate was suction-filtered to dryness, and dried at 60 °C for 24 h before use.

[0023] ② Add the above pre-oxidized dry graphite powder to 240 mL of cold concentrated H 2 SO 4 , stir well and add KMnO 4 Powder 30 g, put the beaker in an ice-water bath, keep the temperature of the reaction system in this step below 20 ° C, to KMnO 4 completely dissolved.

[0024] ③The temperature of the mixed system was raised to 35 °C and stirred for 2 h, then 500 mL of deionized water was added to the reaction system and stirred for 2 h. Then add 1.4 L of deionized water and 40 mL of 30...

Embodiment 2

[0033] (1) Preparation of GO: Same as Example 1;

[0034] (2) Preparation of nitrated graphene oxide (NGO)

[0035] ① Add the above GO to deionized water to obtain a GO dispersion with a concentration of 1-3 mg / mL;

[0036] ②Take 80 mL of GO with a concentration of 2 mg / mL, add 20 mL of concentrated nitric acid (wt≥65%) while stirring gently, and continue stirring for 10-30 min to make it fully mixed;

[0037] ③The reaction solution was transferred to a 100 mL stainless steel Teflon-lined autoclave, and the reaction was sealed at 150 °C for 20 h;

[0038] ④ After the reaction, the cooled reaction solution was transferred to a 250 mL beaker, heated and evaporated to dryness in a water bath at 60-80 °C, and the resulting brown-yellow powder was NGO.

[0039] Bactericidal performance of NGO: NGO with a concentration of 30 μg / mL was effective against Escherichia coli (10 7 CFU / mL) bactericidal rate of 91.26%, against Staphylococcus aureus (10 7 CFU / mL) the bactericidal rate ...

Embodiment 3

[0041] (1) Preparation of GO: Same as Example 1;

[0042] (2) Preparation of nitrated graphene oxide (NGO)

[0043] ① Add the above GO to deionized water to obtain a GO dispersion with a concentration of 1-3 mg / mL;

[0044] ② Take 70 mL of GO with a concentration of 3 mg / mL, add 30 mL of concentrated nitric acid (wt ≥ 65%) while stirring gently, and continue stirring for 10-30 min to make it fully mixed;

[0045] ③Transfer the reaction solution to a 100 mL stainless steel Teflon-lined autoclave, and react in a sealed environment at 180°C for 15 hours;

[0046] ④ After the reaction, transfer the cooled reaction liquid to a 250 mL beaker, heat and evaporate to dryness in a water bath at 60°C-80°C, and the resulting brown-yellow powder is NGO.

[0047] Bactericidal performance of NGO: NGO with a concentration of 30 μg / mL was effective against Escherichia coli (10 7 CFU / mL) bactericidal rate of 85.32%, against Staphylococcus aureus (10 7 CFU / mL) the bactericidal rate was 70....

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Abstract

The invention discloses a preparation method of nitrated graphene oxide, which comprises the following steps: adding graphene oxide into deionized water to obtain a graphene oxide dispersion liquid with the concentration of 1-3mg / mL, then adding concentrated nitric acid, uniformly stirring and mixing, carrying out hydrothermal reaction at 120-180 DEG C for 10-20 hours, and after the reaction is finished, heating in a water bath and evaporating to dryness to obtain brown yellow powder, namely nitrated graphene oxide NGO. The nitrated graphene oxide is simple in preparation method, good in water dispersion performance, high in oxidation degree and good in cell compatibility, the antibacterial performance on gram-positive bacteria and gram-negative bacteria is remarkably improved, and the nitrated graphene oxide can serve as a novel efficient antibacterial material to be used in the fields of biomedicine and the like.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method of nitrated graphene oxide. Background technique [0002] Pathogenic bacteria are one of the greatest threats to human health, causing millions of infections each year. Since the discovery of penicillin in 1928, various antibiotics such as chloramphenicol, erythromycin, and streptomycin have been discovered and used in medicine to treat infections caused by various bacteria. However, with the widespread use of antibiotics, bacteria will gradually change their physiological or metabolic pathways to resist the effects of antibiotics and eventually evolve into drug-resistant bacteria. Nowadays, with the continuous emergence, abuse and long-term use of various antibiotics, the drug resistance of various bacteria, especially animal pathogens, is also increasing, and even multi-drug resistant bacteria that can resist multiple antibiotics appear, whi...

Claims

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Application Information

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IPC IPC(8): C01B32/198
CPCC01B32/198
Inventor 张继宋珅丁玲刘小媛黄玉龙杨生荣范增杰
Owner NORTHWEST NORMAL UNIVERSITY
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