Preparation method and application of anticoagulant copolymer

A copolymer and anticoagulant technology, applied in drug delivery, pharmaceutical formulations, prostheses, etc., can solve the problems of coagulation, microbial contamination, lack of anticoagulation, anti-infection, anti-protein adsorption and anti-thrombotic properties, etc. Improve anticoagulant effect

Active Publication Date: 2021-06-29
WUHAN YONGSEN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a material for implant / interventional medical devices, when polyurethane is in contact with tissue or blood, due to the inherent biological inertia of its surface and the lack of effective anticoagulant, anti-infection, anti-protein adsorption, and anti-thrombotic properties, it is easy to cause material Serious problems such as coagulation, bacterial infection, and inflammatory reactions occur due to microbial contamination on the surface

Method used

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  • Preparation method and application of anticoagulant copolymer
  • Preparation method and application of anticoagulant copolymer
  • Preparation method and application of anticoagulant copolymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A copolymer suitable for modifying large-diameter blood vessels, the preparation method of which is as follows:

[0040] (1) Preparation of anticoagulant copolymer

[0041] The ratio of each monomer in the present embodiment is as follows:

[0042] The molar ratio of sodium p-styrenesulfonate (A), N-vinylpyrrolidone (B), vinyltriethoxysilane (C) and azobisisobutyronitrile (D) is A:(B+C) :D=75:25:1.5, where B:C=75:25.

[0043]Weigh an appropriate amount of A, B, and C monomers according to the above proportions and dissolve them in 200 mL of DMAc (N,N-dimethylacetamide) solution. Under nitrogen protection, after stirring for 30 minutes, add the initiator azobisiso Butyronitrile, react at 80°C for 20 hours to make addition polymerization of three double bond-containing monomers into polymer polymers.

[0044] The above-mentioned polymer was heated in an aqueous solution of 5wt% sodium hydroxide and N,N-dimethylacetamide (the mass ratio of N,N-dimethylacetamide to water...

Embodiment 2

[0057] A copolymer suitable for modifying small-diameter blood vessels, the preparation method of which is as follows:

[0058] (1) Preparation of anticoagulant copolymer

[0059] The ratio of each monomer in the present embodiment is as follows:

[0060] The molar ratio of sodium p-styrenesulfonate (A), N-vinylpyrrolidone (B), vinyltriethoxysilane (C) and azobisisobutyronitrile (D) is A:(B+C) :D=25:75:1.5, where B:C=75:25.

[0061] Weigh an appropriate amount of A, B, and C according to the above ratio and dissolve them in 200 mL of DMAc solution. Under nitrogen protection, after stirring for 30 minutes, add the initiator azobisisobutyronitrile, and react at 80°C for 20 hours to make 3 Polymerization of monomers containing double bonds into polymers.

[0062] The polymerized polymer was heated in an aqueous solution of 5% sodium hydroxide and N,N-dimethylacetamide (the mass ratio of N,N-dimethylacetamide to water was 1:1) for 1 h, The pyrrolidone five-membered ring of the...

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PUM

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Abstract

The invention belongs to the technical field of medical treatment, and discloses a preparation method and application of an anticoagulant copolymer; the polymer is formed by adding and polymerizing a monomer A, a monomer B and a monomer C in proportion, the monomer A contains a double bond and a sulfonic acid group, the monomer B is a hydrophilic substance containing a double bond and a pyrrole ring, and the monomer C is a hydrophobic substance containing a double bond; and a pyrrole ring of a side chain of the polymer is opened, and vitamins and diosgenin are grafted through esterification reaction. The copolymer can be used for modifying the surface of a polyurethane material, and the modified polyurethane surface has good anticoagulation, anti-infection, anti-protein adsorption and anti-thrombus properties at the same time, and has a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and specifically relates to an anticoagulant, antiinfection, antiprotein adsorption, antithrombotic copolymer that can be used for surface modification of polyurethane materials and its preparation method and application. Background technique [0002] Polycarbonate polyurethane materials are widely used in the biomedical field because of their good in vivo stability, good biocompatibility and excellent physical and mechanical properties. However, as a material for implant / interventional medical devices, when polyurethane is in contact with tissue or blood, due to the inherent biological inertia of its surface and the lack of effective anticoagulant, anti-infection, anti-protein adsorption, and anti-thrombotic properties, it is easy to cause material Serious problems such as coagulation, bacterial infection, and inflammatory reactions occur due to microbial contamination on the surfac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F212/14C08F226/10C08F230/08C08F8/14C08J7/12C08J7/14A61L27/18A61L27/34A61L27/50A61L27/54A61L31/06A61L31/10A61L31/14A61L31/16C08L75/04
CPCC08F212/30C08F226/10C08F230/085C08F8/14C08J7/12C08J7/14A61L31/06A61L31/10A61L31/14A61L31/16A61L27/18A61L27/34A61L27/50A61L27/54A61L27/507C08J2375/04A61L2400/18A61L2300/42A61L2300/404A61L2420/02C08L75/04C08L25/18
Inventor 欧阳晨曦徐天成焦培龙行吴瑶刘思诗
Owner WUHAN YONGSEN BIOTECH
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