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Application and application method of equivalent matrix interference agent in determination of arsenic element content

A technology of matrix interference and application method, which is applied in the field of medical testing, can solve the problems of complex operation and long pre-processing time, and achieve the effect of strong operability, short processing time and high-throughput testing

Pending Publication Date: 2021-06-29
汇毓安莱博(苏州)医药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the pretreatment method for determining the content of arsenic in propadamox hydrochloride is the method of microwave digestion. This method is complicated to operate and takes a long time for pretreatment. Therefore, it is urgent to develop other effective methods to determine it.

Method used

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  • Application and application method of equivalent matrix interference agent in determination of arsenic element content
  • Application and application method of equivalent matrix interference agent in determination of arsenic element content
  • Application and application method of equivalent matrix interference agent in determination of arsenic element content

Examples

Experimental program
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Effect test

Embodiment 1

[0050] An application method of an equivalent matrix interfering agent in the determination of the content of arsenic in a chloride-ion-containing pharmaceutical preparation by ICP-MS, the application steps are as follows:

[0051] Pre-processing:

[0052] Diluent Ⅰ: 1-5% nitric acid; Diluent Ⅱ: 1-5% nitric acid solution with 2% isopropanol;

[0053] Arsenic element stock solution: pipette 0.25mL of 1000μg / mL arsenic element standard solution into a 50mL volumetric flask, dilute to the mark with diluent Ⅰ, the arsenic element concentration is 5μg / mL;

[0054] Arsenic element standard linear solution: pipette 20 μL, 50 μL, 100 μL, 150 μL, 200 μL of arsenic element stock solution into different 10mL volumetric flasks, and dilute to the mark with diluent II to obtain a series of arsenic element standard linear solutions;

[0055] Proparatamol hydrochloride solution: Weigh 0.5g of propatamol hydrochloride into a 10mL volumetric flask, and dilute to the mark with diluent Ⅰ;

[00...

Embodiment 2

[0059] An application method of an equivalent matrix interfering agent in the determination of the content of arsenic in a chloride-ion-containing pharmaceutical preparation by ICP-MS, the application steps are as follows:

[0060] Pre-processing:

[0061] Diluent Ⅰ: 1-5% nitric acid; Diluent Ⅱ: 1-5% nitric acid solution with 2% methanol;

[0062] Arsenic element stock solution: pipette 0.25mL of 1000μg / mL arsenic element standard solution into a 50mL volumetric flask, dilute to the mark with diluent Ⅰ, the arsenic element concentration is 5μg / mL;

[0063]Arsenic element standard linear solution: pipette 20μL, 50μL, 100μL, 150μL, 200μL of arsenic element stock solution into different 10mL volumetric flasks, and dilute to the mark with diluent II to obtain a series of arsenic element standard linear solutions ;

[0064] Proparatamol hydrochloride solution: Weigh 0.5g of propatamol hydrochloride into a 10mL volumetric flask, and dilute to the mark with diluent Ⅰ;

[0065] Pro...

Embodiment 3

[0068] An application method of an equivalent matrix interfering agent in the determination of the content of arsenic in a chloride-ion-containing pharmaceutical preparation by ICP-MS, the application steps are as follows:

[0069] Pre-processing:

[0070] Diluent Ⅰ: 1-5% nitric acid; Diluent Ⅱ: 1-5% nitric acid solution with 4% isopropanol;

[0071] Arsenic element stock solution: pipette 0.25mL of 1000μg / mL arsenic element standard solution into a 50mL volumetric flask, dilute to the mark with diluent Ⅰ, the arsenic element concentration is 5μg / mL;

[0072] Arsenic element standard linear solution: pipette 20μL, 50μL, 100μL, 150μL, 200μL of arsenic element stock solution into different 10mL volumetric flasks, and dilute to the mark with diluent II to obtain a series of arsenic element standard linear solutions ;

[0073] Proparatamol hydrochloride solution: Weigh 0.5g of propatamol hydrochloride into a 10mL volumetric flask, and dilute to the mark with diluent Ⅰ;

[0074]...

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Abstract

The invention provides an application and an application method of an equivalent matrix interference agent in determination of arsenic element content. The application comprises the following steps: (1) dissolving chloride ion-containing medicinal preparation powder with a 1-5wt% nitric acid solution, and fixing the volume to obtain a sample solution; (2) preparing an arsenic element standard linear solution, and adding an equivalent matrix interference reagent; and (3) detecting in a KED mode of an ICP-MS (inductively coupled plasma mass spectrometer). According to the application of the equivalent matrix interference agent in determination of the arsenic element content and the application method provided by the invention, when the content of the arsenic element in a chloride ion-containing pharmaceutical preparation is determined by adopting ICP-MS, the equivalent matrix interference agent can effectively and equivalently offset the matrix interference effect of chloride ions, so that the effective rate and precision of determination are improved.

Description

technical field [0001] The invention relates to the technical field of medical detection, in particular to the application and application method of an equivalent matrix interfering agent in the determination of arsenic element content. Background technique [0002] ICP-MS is commonly used in the field of pharmaceutical analysis for qualitative and quantitative analysis of test elements. ICP-MS (Inductively Coupled Plasma Mass Spectrometry), or Inductively Coupled Plasma Mass Spectrometry, is a new type of technology that combines the high-temperature (10,000K) ionization characteristics of ICP with the advantages of sensitive and fast scanning of quadrupole mass spectrometers with a unique interface technology. Elemental and isotopic analysis techniques. In terms of analytical capabilities, it can replace traditional inorganic analytical techniques such as Inductively Coupled Plasma Spectroscopy (ICP-AES), Graphite Furnace Atomic Absorption (GF-AAs), Flame Atomic Absorptio...

Claims

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Application Information

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IPC IPC(8): G01N27/626
CPCG01N27/626
Inventor 郝鹏超张成龙夏彧程佳晓栾洁徐凌云何扬扬盛绍强
Owner 汇毓安莱博(苏州)医药技术有限公司