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Enrofloxacin injection and preparation method thereof

A technology for enrofloxacin and injection, applied in the field of enrofloxacin injection and its preparation, can solve problems such as poor curative effect and easy crystallization, and achieve the effects of avoiding both symptoms and root causes, good sterilization effect, and overcoming drug resistance.

Pending Publication Date: 2021-07-13
CHONGQING ZONGYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the defects in the prior art, the present invention provides an enrofloxacin injection and a preparation method thereof, so as to solve the technical problem that the enrofloxacin injection in the prior art is easy to crystallize and serious drug resistance leads to poor curative effect

Method used

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  • Enrofloxacin injection and preparation method thereof
  • Enrofloxacin injection and preparation method thereof
  • Enrofloxacin injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] (1) Take 10 parts of enrofloxacin, 1 part of dimethylformamide and 5 parts of tributyrin, stir and heat to 60 degrees to dissolve, and obtain solution A;

[0058] (2) After mixing and dissolving 0.8 parts of nabumetone and 0.4 parts of sodium lauryl sulfate, and then stirring with 5 parts of tributyrin and heating to 60 degrees for dissolution, solution B was obtained;

[0059] (3) Stir and heat 3 parts of glycerin and 10 parts of soybean oil for injection to 50 degrees to obtain solution C;

[0060] (4) Mix solution A, solution B and solution C to obtain solution D;

[0061] (5) Adjust the pH of solution D to 9.5 with ethanolamine, add water for injection to the full amount to obtain enrofloxacin injection, and finally filter the obtained enrofloxacin injection with a 0.45 μm microporous membrane, and pour Seal in an ampoule and sterilize at 110°C for 40 minutes under circulating steam.

Embodiment 2

[0063] (1) Take 13 parts of enrofloxacin, 2 parts of dimethylformamide and 6 parts of tributyrin, stir and heat to 60 degrees to dissolve, and obtain solution A;

[0064] (2) Mix and dissolve 1 part of nabumetone and 0.5 part of sodium lauryl sulfate, then stir and heat to 60 degrees with 7 parts of tributyrin to dissolve, and obtain solution B;

[0065] (3) 5 parts of glycerin and 15 parts of soybean oil for injection were stirred and heated to 50 degrees to obtain solution C;

[0066] (4) Mix solution A, solution B and solution C to obtain solution D;

[0067] (5) Use ethanolamine to adjust the pH of solution D to 10, add water for injection to the full amount to obtain enrofloxacin injection, and finally filter the obtained enrofloxacin injection with a 0.45 μm microporous membrane, and pour Seal in an ampoule and sterilize at 110°C for 40 minutes under circulating steam.

Embodiment 3

[0069] (1) Take 15 parts of enrofloxacin, 3 parts of dimethylformamide and 7 parts of tributyrin, stir and heat to 60 degrees to dissolve, and obtain solution A;

[0070] (2) After mixing and dissolving 1.2 parts of nabumetone and 0.6 parts of sodium lauryl sulfate, and then stirring with 8 parts of tributyrin and heating to 60 degrees for dissolution, solution B was obtained;

[0071] (3) 6 parts of glycerin and 20 parts of soybean oil for injection were stirred and heated to 50 degrees to obtain solution C;

[0072] (4) Mix solution A, solution B and solution C to obtain solution D;

[0073] (5) Use ethanolamine to adjust the pH of solution D to 10.5, add water for injection to the full amount to obtain enrofloxacin injection, and finally filter the obtained enrofloxacin injection with a 0.45 μm microporous membrane, and pour Seal in an ampoule and sterilize at 110°C for 40 minutes under circulating steam.

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Abstract

The invention provides an enrofloxacin injection. The enrofloxacin injection comprises the following raw materials in percentage by weight: 10% to 15% of enrofloxacin; 0.4% to 0.6% of lauryl sodium sulfate; 1% to 3% of dimethyl formamide; 10% to 15% of tributyrin; 3% to 6% of glycerin; 10% to 20% of soybean oil for injection; 2% to 5% of ethanol; 0.8% to 1.2% of nabumetone; and the balance of water for injection. The enrofloxacin injection is high in stability, no crystal is separated out after the enrofloxacin injection is placed for two years at -36 DEG C, and the effective rate of the enrofloxacin injection is 98% after the enrofloxacin injection is subcutaneously injected at a high dose; the cure rate reaches 94%, and the enrofloxacin injection has the special effects of being stable, quick-acting, efficient and long-acting, avoiding drug resistance and treating both symptoms and root causes.

Description

technical field [0001] The invention relates to the technical field of veterinary drugs, in particular to an enrofloxacin injection and a preparation method thereof. Background technique [0002] Enrofloxacin is a broad-spectrum high-efficiency antibiotic for animals. It is widely distributed in animals and can quickly kill pathogenic bacteria. Streptococcus, Streptococcus, etc. all have bactericidal effect and have special effects on mycoplasma. They are widely used in clinical practice, but they are prone to drug resistance. After more than 20 years of clinical use, drug resistance generally occurs, resulting in a greatly reduced curative effect. [0003] The effect of enrofloxacin injection with a content of 5% is no longer obvious, while enrofloxacin has strong intermolecular polarity, and the injection solution with a content of 10% has poor stability and is prone to turbidity and crystallization, which is especially serious in winter in the north, causing many manufact...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/496A61K31/12A61K47/44A61P31/04A61P29/00A61P7/10
CPCA61K9/08A61K9/0019A61K31/496A61K31/12A61K47/44A61P31/04A61P29/00A61P7/10A61K2300/00
Inventor 梁金权
Owner CHONGQING ZONGYI PHARMA
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