Application of pharmaceutical composition containing chlorogenic acid in preparation of antiviral drugs

An antiviral drug, chlorogenic acid technology, applied in the field of medicine, can solve the problems of toxic and side effects of organs such as liver and kidney, difficult to cure chronic diseases, and low clinical efficacy, achieve high oral bioavailability, and improve oral pharmacokinetic parameters. , the effect of reducing lung index
CN113143903AActive Publication Date: 2021-07-23TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
Publication Date
2021-07-23

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Abstract

The invention discloses application of a pharmaceutical composition containing chlorogenic acid in preparation of antiviral drugs. Experiments prove that the pharmaceutical composition containing the chlorogenic acid can resist viruses. The pharmaceutical composition containing the chlorogenic acid is high in oral bioavailability, and oral drug kinetic parameters of the raw material chlorogenic acid are improved. The pharmaceutical composition containing the chlorogenic acid can obviously inhibit weight loss of virus infected mice, reduce lung indexes, inhibit lung tissue inflammatory factors, resist inflammatory storm, reduce the virus load of lung tissues and resist damage of influenza A viruses and human coronavirus to lungs.
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Description

technical field

[0001] The invention relates to the field of medicine, in particular to the application of a pharmaceutical composition containing chlorogenic acid in the preparation of antiviral drugs. Background technique

[0002] Chlorogenic acid (CGA) widely exists in medicinal plants, mainly in Lonicera and Eucommia, such as honeysuckle and Eucommia. The solubility of chlorogenic acid in water at 25°C is 4%, and the solubility in hot water is even greater. It is easily soluble in ethanol and acetone, slightly soluble in ethyl acetate, and hardly soluble in chloroform and ether.

[0003] At present, studies have shown that chlorogenic acid has the effect of preventing and treating lung injury, can inhibit the increase of myeloperoxidase activity in lung tissue caused by lipopolysaccharide and the expression of polymorphonuclear leukocytes in alveolar lavage fluid, and significantly reduce the lung damage. Inducible nitric oxide synthase activity in tissues; in addition,...

Claims

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