An implanted bandage for promoting the repair of bone damage and its preparation method

A bone injury repair and bandage technology, applied in the field of biomedical implant materials, can solve problems such as endangering the healing efficiency of bone injury, lack of periosteum-derived stem cells, and adverse effects of bone injury, so as to solve the problem of delayed bone injury healing and repair, and avoid soft tissue damage. Effects of ingrowth and sequestration, improving biocompatibility

Active Publication Date: 2022-06-28
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] One is that the continuous inflammatory response caused by muscle tissue trauma may have an adverse effect on the internal repair of bone damage, and the need for timely healing of muscle trauma and the prevention and control of infection
[0006] The second is that the blood supply in the bone defect is seriously affected after the periosteum is damaged. The reconstruction and repair process of the periosteum itself cannot provide positive support for the nutrition supply for the repair of the bone injury, and the lack of periosteum-derived stem cells will also endanger the improvement of the healing efficiency of the bone injury.

Method used

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  • An implanted bandage for promoting the repair of bone damage and its preparation method
  • An implanted bandage for promoting the repair of bone damage and its preparation method
  • An implanted bandage for promoting the repair of bone damage and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Example 1: 0.04-8 μm, the particle size of the inorganic mineral particles is 0.02-40 μm.

[0095] 1) The mesoporous bioglass nanopowder (chemical composition is 28CaO-42SiO) with a particle size of 0.15-0.85μm 2 -12B 2 O 3 -4P 2 O 5 -6MgO-1CuO-2ZnO-4Na 2 O-1K 2 O) Add to the hyaluronic acid-gelatin composite aqueous solution with a mass ratio of 1:9 and stir evenly, the mass ratio of bioglass to organic matter is 1:20, and prepare an organic-inorganic composite with a bioglass concentration of 50 mg / ml The solution was then transferred to the electrospinning reservoir, the spinning distance was set to 15 cm, the spinning voltage was 16 kV, and electrospinning was carried out at a speed of 0.4 ml / hour, and then the porous copper foil carrier was collected on a porous copper foil carrier with a thickness of 200. Micron-level microfiber porous membrane;

[0096] 2) The organic substance used for preparing the poly-L-lactide-caprolactone porous mesh is directly plac...

Embodiment 2

[0100] 1) Mesoporous bioglass particles with a particle size of 0.50-1.20 μm (chemical composition 24CaO-48SiO) 2 -12B 2 O 3 -2P 2 O 5 -6MgO-4ZnO-4Na 2 O) join in the sodium alginate-gelatin composite solution that the ratio of mass is 2:5 and stir, the mass ratio of ultrafine particles and organic matter is 1:15, and it is organic-inorganic that the concentration of ultrafine particles is 20mg / ml. The composite solution was then transferred to the electrospinning reservoir, the spinning distance was set to 18 cm, the spinning voltage was 18 kV, and the electrospinning was carried out at a speed of 0.3 ml / h, and then collected on an aluminum foil carrier with a thickness of 150 Micron-level microfiber porous membrane;

[0101] 2) The organic substance used to prepare the polycaprolactone porous grid is directly placed in the material container of the three-dimensional printer, and the polymer is softened by heating and extruded out of the printing nozzle. The microfiber p...

Embodiment 3

[0105] 1) The mesoporous bioglass powder (24CaO-56SiO) with a particle size of 0.32 to 1.10 μm 2 -8B 2 O 3 -4MgO-2ZnO-6Na 2 O) join in the sodium alginate-gelatin-polyvinylphosphoric acid composite organic matter solution that the ratio of mass is 2:8:1 and stir, the mass ratio of ultrafine particles and organic matter is 1:15, and the concentration of ultrafine particles is formulated as 20 mg / ml of the organic-inorganic composite solution, then transferred to the reservoir for electrospinning, the spinning distance was set to 16 cm, the spinning voltage was 20 kV, and the electrospinning was carried out at a speed of 0.4 ml / hour, and then Collect the microfiber porous film with a thickness of 280 microns on the aluminum foil drum carrier;

[0106] 2) The organic matter used to prepare the sodium carboxymethyl cellulose porous mesh is directly placed in the material container of the three-dimensional printer, and the polymer is softened by heating and extruded out of the p...

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Abstract

The invention discloses an implantable bandage material and a preparation method for promoting bone damage repair. The bandage is composed of a porous grid sheet and its two sides are covered by an organic-inorganic composite ultrafine fiber porous film. The lower layer is an ultrafine fiber porous network containing biological glass particles, the middle layer is a polymer porous grid, and the upper layer is It is composed of ultrafine fiber porous network containing inorganic mineral particles; the inorganic substances in the ultrafine fibers on both sides of the surface are biological glass particles that inhibit inflammation, anti-infection and promote soft tissue regeneration and repair, and inorganic minerals that inhibit inflammation and promote bone regeneration and repair Composed of microparticles, the bandage is prepared by three-dimensional printing and electrospinning processes. The method of the invention is easy to operate, has significant inhibitory effect on inflammation in soft and hard tissues such as muscles, periosteum and bones of various fractures or bone defects, and promotes rapid healing and repair of soft and hard tissues, and the degradation rate of implantable bandages It can be regulated and has significant antibacterial effect on common pathogenic bacteria and fungi.

Description

technical field [0001] The invention belongs to an implanted bandage and a preparation method thereof in the field of biomedical implant materials, in particular to an implanted bandage material and a preparation method for promoting the synergistic regeneration and repair of soft and hard tissues of bone injury. Background technique [0002] Bone injuries usually include fractures and bone defects, which may also be referred to as bone trauma and bone loss. In my country, more than 100,000 people die every year from fractures or bone trauma caused by accidents such as traffic accidents, falls, smashes, and falls. Defects or bone loss, especially in the middle-aged and elderly people at the site of bone damage caused by various chronic diseases and inflammation, have poor blood supply and slow recovery, resulting in delayed fracture union, malunion or even nonunion (nonunion). Although there is a broad consensus and experience in the clinical practice of conventional fractur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F13/00
CPCA61F13/00012A61F13/00991A61F2013/00548
Inventor 苟中入杨贤燕徐三中
Owner ZHEJIANG UNIV
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