Centrifugal micro-fluidic device for rapidly preparing liquid drops and liquid drop preparation method

Abstract

The invention discloses a centrifugal micro-fluidic device for rapidly preparing liquid drops and a liquid drop preparation method, and belongs to the technical field of biomedical materials.The centrifugal micro-fluidic device comprises an inner liquid storage device and an outer liquid storage device which are provided with hollow inner cavities, wherein inner phase liquid is injected into the inner liquid storage device, a collecting groove is formed in the bottom end of the inner cavity of the outer liquid storage device, outer phase liquid is injected into the collecting groove, and the inner liquid storage device and the center line are arranged in the inner cavity of the outer liquid storage device; a capillary tube installed on the inner liquid storage device, wherein one end of the capillary tube is communicated with the inner cavity of the inner liquid storage device, and the other end of the capillary tube is positioned above the collecting groove; and a centrifugal transmission mechanism which is connected with the inner liquid storage device and can drive the inner liquid storage device to rotate at a high speed and enable the inner phase liquid to do centrifugal motion in the inner liquid storage device, wherein centrifugal force borne by the inner phase liquid during centrifugal motion can extrude the inner phase liquid to enter the tube from one end of the capillary tube and generate liquid drops at the other end of the capillary tube. The device has the advantages that high-flux production of the liquid drops can be realized, and meanwhile, the size and the shape of the liquid drops are flexible and controllable.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a centrifugal microfluidic device for rapidly preparing liquid droplets and a method for preparing liquid droplets. Background technique [0002] Droplets have good diversity and designability, and have great application potential in the fields of chemical engineering, food industry, energy utilization, biomedical engineering, electronic cooling, and drug delivery; droplets can be transformed into various forms after processing Such as gels, microspheres, etc., these microspheres or gels have good mechanical properties, transport properties and release properties; traditional emulsification methods use high-speed stirring to disperse one solution in another solution to form A variety of droplets, the intermediate emulsion can also be further emulsified to form higher-order multi-emulsion droplets, but the above method has many problems such as inability to accurately...

AI Technical Summary

Problems solved by technology

However, due to factors such as the wettability of the microchannel and high flow resistance, the traditional shear force-based microfluidic technology usually has a low yield and is difficult to meet the requirements of high-throughput preparation; based on this, a centrifugal microfluidic technology is currently being developed. The research of fluidic technology is expected to solve the above technical problems. The current specific implementation method is usually based on the centrifugal microfluidic method of the chip, that is, the chip with complex microchannels is made by photolithography and other methods, and the precursor solution is injected into the corresponding microfluidics. The reaction in the microchannel generates droplets; although this method can prepare highly monodisperse droplets, the cost and technical requirements of this method are high, and only a small amount of precursor solution can be stored, which greatly limits the size of the droplets. Yield

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