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Nanocapsules coated with chitosan and use thereof

A nanocapsule, chitosan technology, applied in microcapsules, capsule delivery, nanocapsules, etc., can solve the problems of undocumented nanocapsule skin penetration effect, etc., and achieve excellent stability, excellent delivery efficiency, and improved delivery efficiency. Effect

Active Publication Date: 2021-08-06
SKINMED CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also, Korean Patent No. 1748127 describes a nanoparticle coated with chitosan on nanoparticles containing a drug and pluronic (poloxamer). Nanoparticles of polyglycolic acid copolymer (PLGA) are coated with chitosan, and its composition is different from the nanocapsules of the present invention that use chitosan to coat nanoparticles consisting only of drugs and pranik , and the excellent skin penetration effect of the nanocapsules of the present invention is not described

Method used

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  • Nanocapsules coated with chitosan and use thereof
  • Nanocapsules coated with chitosan and use thereof
  • Nanocapsules coated with chitosan and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] Embodiment 1. Preparation is coated with the nanocapsule of chitosan

Embodiment 1-1

[0116] Example 1-1. Optimizing the Preparation of Nanoparticles According to Pluronic Species

[0117] Pluronic (poloxamer) is a kind of poly(ethylene oxide) (poly(ethylene oxide), PEO) of hydrophilic polymer and poly(propylene oxide) of hydrophobic polymer (poly(propylene oxide) ), PPO) composed of non-ionic PEO-PPO-PEO triblock copolymers, is a representative temperature-sensitive polymer, which has the unique characteristic of reversibly changing the internal structure as the temperature rises. According to the added moles of poly(ethylene oxide) and poly(propylene oxide) of Planik, there are Planik derivatives with various hydrophilic-lipophilic balance values. The hydrophilic-lipophilic balance value of can have an effect on particle size. For this purpose, the size of the nanoparticles according to the Planik species was confirmed.

[0118] Nanoparticles were prepared using pluronic with a hydrophilic-lipophilic balance of 2-29. Specifically, a reaction solution was...

Embodiment 1-2

[0122] Example 1-2. Optimizing the preparation of nanocapsules according to Pranik species

[0123] In order to confirm the optimal conditions for the preparation of nanocapsules according to the pranik species, nanoparticles were prepared by using pranik corresponding to the hydrophilic-lipophilic balance value of 2 to 29 in Table 1 below, and coated with chitosan. nanocapsules.

[0124] Specifically, 20 mg of pluronic was dissolved in 1 ml of acetone, and stirred at room temperature for 2 hours. Subsequently, after polymer nanoparticles were prepared by slowly dropping the polymer solution into 4 ml of triple distilled water (deionized water) stirred at 400 rpm, acetone was removed in a fume hood for about 6 hours. Finally, 20 mg of chitosan with a deacetylation rate of 90% and a molecular weight of 10 kDa was added to each polymer nanoparticle, and stirred at room temperature for 2 hours to prepare chitosan nanocapsules. The size, dispersion and surface charge of chitos...

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Abstract

The present invention relates to nanocapsules coated with chitosan, and a use thereof. A method for preparing nanocapsules having a particle size of 500 nm or less, or 300 nm, especially, 100 nm or less, and excellent stability has been established, and it has been ascertained that a poorly soluble drug is loaded in the nanocapsules prepared by the method, so that an excellent skin permeability rate of drug-containing nanocapsules, drug delivery into the skin achieved thereby, and efficacy caused by the drug are exhibited. In addition, an increase in the bioavailability of active ingredients in vivo through oral administration of the prepared nanocapsules is confirmed, and thus it is expected that nanocapsules coated with chitosan of the present invention are used to develop an excellent delivery system, of which the delivery efficiency of a poorly soluble drug or the active ingredients to animals such as humans, livestock, and companion animals is significantly increased, in the pharmaceutical field, cosmetics industry, food industry, and the like.

Description

technical field [0001] The invention relates to a nanocapsule coated with chitosan and an application thereof, in more detail, relates to a nanocapsule coated with pluronic-containing nanoparticles by chitosan and an application thereof. Background technique [0002] Nanoparticles (nanoparticles) refer to substances in the form of particles that are generally larger than atoms and smaller than cells, with a diameter in the range of 1 to 1000 nm. Create materials for new application areas. In particular, applications in the field of electronic components utilizing electromagnetic properties, the fields of medicine and cosmetics utilizing drug absorption properties, and the fields of photocatalysts or fuel cells have greatly increased. [0003] Typically, nanoparticles can be prepared using inactive materials such as polymeric materials such as gold, tin oxide, albumin, etc., compared to particles with larger diameters , these levels of particles, when applied to biological ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K8/11A61K8/73A61Q19/00A23L33/10
CPCA61Q19/00A23L33/28A61K9/14A61K9/0053A61K9/5036A61K9/5161A61K9/5146A61K9/1641A61K31/337A61K31/573A61K31/355A61K31/122A61K31/12A61K31/375A61K31/216A61K31/23A61K31/506A61K31/58A61K31/575A61K31/4741A61K2800/10A61K8/736A61K8/90A61K8/0241A61K2800/624A61K2800/654A61K2800/413A61K38/13A61K38/39A61K38/38A61K38/1825A61K38/1866A61K38/465Y02A50/30A61K8/11A23L33/10A23V2002/00A23V2200/25A23V2250/511
Inventor 崔源日金成炫慎镛喆李增壎金镇和尹荣晟
Owner SKINMED CO LTD
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