Methods of inhibiting neutrophil recruitment to the gingival crevice

A technology of neutrophils and gums, applied in non-central analgesics, dentistry, pharmaceutical formulations, etc., can solve problems such as permanent damage to teeth and jaws

Pending Publication Date: 2021-08-13
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, untreated, gingivitis can become an advanced stage of gum disease, periodontitis, and cause permanent damage to the teeth and jaw

Method used

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  • Methods of inhibiting neutrophil recruitment to the gingival crevice
  • Methods of inhibiting neutrophil recruitment to the gingival crevice
  • Methods of inhibiting neutrophil recruitment to the gingival crevice

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0054] figure 1 Contains a schematic representation of the gingival sulcus model (GCM). GCM is suitable for assessing product health benefits in a cell culture model that closely mimics the gingival sulcus. The gingival sulcus is home to hundreds of bacterial species as well as gingival epithelial cells and neutrophils. The proteomics, bacterial influence and odor of secreted or expressed proteins can be evaluated and used to compare the effects of various compounds and compositions. GCM combines three components, neutrophil-like cells, biofilm including oral bacteria, and oral epithelial tissue.

[0055] Neutrophil-like cells: HL60 cells (ATCC #CCLO-240) can be induced to differentiate into neutrophil-like cell types by exposing HL60 cells to retinoic acid. HL60 cells were maintained at 1 x 10 5 cells / ml (medium for HL60, IMEM ATCC#30-2005) at a cell density. Retinoic acid used to differentiate HL60 into neutrophil-like cells was prepared by dissolving retinoic acid in E...

example 2

[0071] Oral compositions comprising arginine are disclosed in WO 2017 / 223292, which is incorporated herein by reference. In some embodiments, an oral care composition comprises an orally acceptable carrier, zinc phosphate; and stannous fluoride. In some embodiments, the zinc phosphate is a preformed salt of zinc phosphate. In some embodiments, the zinc phosphate is present in an amount sufficient to dissociate stannous fluoride to provide a therapeutically effective amount of stannous ions in the aqueous solution. In some embodiments, the amount of zinc phosphate is 0.05% to 5% by weight relative to the weight of the oral care composition. In some embodiments, the amount of stannous fluoride is 0.05% to 5% by weight relative to the weight of the oral care composition. In some embodiments, the amount of water is about 12% by weight or greater relative to the weight of the oral care composition. In some embodiments, the oral care composition further comprises an abrasive and / ...

example 3

[0073] Oral compositions comprising arginine are disclosed in WO 2017 / 223311, which is incorporated herein by reference. The oral care composition is the oral care composition set forth in Example 2, further comprising an organic acid buffer system. In some embodiments, the oral care composition comprises water in an amount of 10% by weight or greater relative to the weight of the oral care composition. In some embodiments, the organic buffer system comprises a carboxylic acid and one or more conjugate base salts thereof, such as alkali metal salts thereof. In some embodiments, the acid is selected from citric acid, lactic acid, malic acid, maleic acid, fumaric acid, acetic acid, succinic acid, and tartaric acid. In some embodiments, the one or more conjugate base salts are independently selected from sodium and potassium salts or combinations thereof. In some embodiments, the acid is citric acid, and the one or more conjugate base salts include monosodium citrate (monobase)...

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Abstract

Methods of increasing proteins that reduce signals associated with neutrophil recruitment and reducing proteins that induce neutrophil recruitment within an individual's gingival crevice are disclosed. The methods comprise applying to the individual's oral cavity in an amount effective to increase proteins that reduce signals associated with neutrophil recruitment and reduce proteins that induce neutrophil recruitment within an individual's gingival crevice, an oral care composition comprising: zinc phosphate, stannous fluoride and optionally, an organic acid buffer system.

Description

Background technique [0001] The gingiva (gum / gingiva) is the part of the soft tissue lining of the mouth that surrounds and provides a seal around the teeth. The gingival margin is the interface between the gingival sulcus epithelium and the oral epithelium. This interface exists at the most coronal point of the gingiva, also known as the coronal portion of the marginal gingiva. The gingival sulcus, also known as the sulcus, is the space surrounding the tooth between the wall of unattached gum tissue and the enamel and / or cementum. [0002] Gum disease is inflammation of the gum line that can progress to affect the bone that surrounds and supports your teeth. The three stages of gum disease from mildest to most severe are gingivitis, periodontitis, and advanced periodontitis. [0003] Gingivitis is the initial stage of gum disease. The immediate cause of gingivitis is plaque - the soft, sticky, colorless film of bacteria that continually forms on the teeth and gums. If pl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/19A61K8/21A61K8/24A61K8/27A61Q11/00A61P1/02A61P29/00
CPCA61K8/27A61K8/24A61K8/21A61K8/19A61Q11/00A61P1/02A61P29/00A61K2800/28A61K2800/92
Inventor 卡米耶·泽诺比娅卡洛·德埃普陈丹丹哈什·马亨德拉·特里维迪詹姆斯·马斯特斯
Owner COLGATE PALMOLIVE CO
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