Anti-inflammatory composition and preparation method and application thereof

A technology of composition and application, which is applied in the field of anti-inflammatory composition and its preparation, can solve the problems of poor adaptability of users, poor taste of medicine, poor efficacy, etc., and achieve good taste, good application prospect, easy consumption and The effect of swallowing

Inactive Publication Date: 2021-08-20
SICHUAN GUOKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, when Chinese medicines are prepared into medicines for treating chronic pharyngitis, there are still problems of poor efficacy; at the same time, the medicines prepared from some Chinese medicines have side effects such as easy to get angry after long-term use; in addition, because Chinese medicines have a special smell, the prepared The taste of the medicine is not good, and the entrance is bitter, which leads to poor adaptability of the users

Method used

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  • Anti-inflammatory composition and preparation method and application thereof
  • Anti-inflammatory composition and preparation method and application thereof
  • Anti-inflammatory composition and preparation method and application thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1, composition of the present invention is prepared into buccal tablet

[0039] Composition of the present invention is prepared into buccal tablet, and specific method is as follows:

[0040] (1) Preparation of Amla emblica extract: Take high-quality emblica emblica fruit that is free from diseases and insect pests, wash and dry, crush in a crusher, filter coarsely with cloth, and after standing for several hours, take out the supernatant to obtain Phyllanthus emblica extract. Add 6g of salt per 100g of the extract, and carry out precipitation treatment (stand still for more than 6 hours, take the supernatant) to obtain the stock solution. Concentrate the original solution under reduced pressure until the volume of the remaining original solution is 1 / 8. The concentration experiment environment is 60° C. and the pressure is 68 kPa. The obtained concentrated solution is the concentrated solution of the extract of Emlical root.

[0041] (2) Preparation of As...

Embodiment 2

[0047] Embodiment 2, the influence of composition of the present invention on agar-induced swelling of rat paws

[0048] Take 70 SD rats provided by Sichuan Dashuo, male SD rats with a body weight of 200±20g, and randomly divide them into 7 groups: blank control group, model group, emblica group, astragalus group, peppermint oil group, and the combination of the present invention Drug group and positive control group (hydrocortisone acetate). Amla emblica group, astragalus root group and peppermint oil group used the emblica extract concentrate, astragalus root extract and peppermint oil prepared in Example 1, respectively. The composition group of the present invention is a mixture obtained by mixing the emblica extract concentrate, astragalus extract extract and peppermint oil prepared in Example 1 at a mass ratio of 5:4:1. The dose of hydrocortisone acetate was 5 mg / kg, and the dose of other groups was 10 mg / kg.

[0049] The positive control group was injected with hydroc...

Embodiment 3

[0054] Embodiment 3, the therapeutic effect of composition of the present invention to chronic pharyngitis

[0055] Adopt random single-blind method, select chronic pharyngitis case to take respectively the buccal tablet (test group) that the embodiment of the present invention 1 prepares and grass coral buccal tablet (positive control group), each 0.5g*3 sheet, every day 4 times, Take continuously for 7 days. A total of 33 cases were observed in the test group and 26 cases in the positive control group. The results showed that the total effective rate of the test group was as high as 93.9% for the treatment of chronic pharyngitis, and the total effective rate of the positive control group was 80%. After statistical analysis, the test group had an obvious curative effect on chronic pharyngitis. Better than the positive control group (P<0.05). It shows that the composition of the present invention has a good therapeutic effect on chronic pharyngitis, and has the effects of rel...

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Abstract

The invention provides an anti-inflammatory composition and a preparation method and application thereof, and belongs to the field of traditional Chinese medicines. The composition is prepared from the following raw materials in parts by weight: 1-10 parts of phyllanthus emblica extract, 1-5 parts of astragalus extract and 1-5 parts of peppermint oil. The composition disclosed by the invention has remarkable antibacterial and anti-inflammatory effects, and has a synergistic interaction effect compared with that of independently used raw materials; meanwhile, the composition disclosed by the invention also has the effects of detoxifying, relieving sore throat, promoting salivation, relieving cough, strengthening qi and nourishing, and can be used for treating diseases such as chronic pharyngitis and the like. Besides, after the composition is prepared into the buccal tablets according to the method, the unique faint scent flavor of the phyllanthus emblica and the astragalus is reserved, the buccal tablets have light peppermint oil fragrance, are cool and delicious, are fine and smooth in mouth feel, are free of bitterness and astringent taste, are excellent in mouth feel and do not have bad feelings after being taken, and the bad symptoms of dry mouth and the like which often occur after the traditional astragalus buccal tablets are taken are solved; the buccal tablets are easy to take and swallow and the patient adaptability is good. The composition disclosed by the invention has a good application prospect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to an anti-inflammatory composition, a preparation method and application thereof. Background technique [0002] Chronic pharyngitis is chronic inflammation of pharyngeal mucosa, submucosa and lymphoid tissue, and is a common and frequently-occurring disease in otolaryngology. Chronic pharyngitis is based on local symptoms, such as pharyngeal discomfort, foreign body sensation, pharyngeal secretions that are difficult to spit out, pharyngeal itching, burning, dryness or irritation, and slight pain. Chronic pharyngitis mostly develops from acute pharyngitis. With the changes of modern natural environment and social environment, the incidence of chronic pharyngitis is increasing year by year. Patients with chronic pharyngitis often have irritating cough and nausea when they wake up in the morning, and also have habitual dry cough and sputum clearing. Chronic p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/534A61K9/20A61K47/69A61P11/04A61P39/02A61P11/14A61P1/14A61P29/00A23L33/105A23P10/28C11B1/10C11B3/12C11B3/00
CPCA61K36/47A61K36/481A61K36/534A61K9/0056A61K9/2018A61K47/6951A61P11/04A61P39/02A61P11/14A61P1/14A61P29/00A23L33/105A23P10/28C11B1/10C11B3/12C11B3/008C11B3/001A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/35A23V2002/00
Inventor 石万棋李同昆吴瑕史焱代明星温万东唐伟陈科邓戊甲尹爽
Owner SICHUAN GUOKANG PHARMA
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