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Lutein ester preparation for tabletting and preparation method thereof

A technology of lutein ester and preparation, which is applied to the field of tableted lutein ester preparation and preparation thereof, can solve the problems of not being able to achieve the ideal protection of lutein ester, easy to break, etc., and achieves good product stability, resistance to The effect of strong pressure resistance, increased stability and pressure resistance

Pending Publication Date: 2021-08-31
CHENGUANG BIOTECH GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The wall material of lutein ester microcapsules usually protects lutein by embedding, but in the process of preparing lutein esters into tablets, due to the operation involved in tablet compression, common lutein ester microcapsules The capsule is very easy to rupture and cannot provide ideal protection for lutein esters, so it is necessary to prepare a lutein ester preparation suitable for tableting to broaden the application range of lutein esters

Method used

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  • Lutein ester preparation for tabletting and preparation method thereof
  • Lutein ester preparation for tabletting and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] This embodiment relates to a preparation method of a lutein ester preparation, comprising the following steps:

[0031] 1) Add 2kg of gelatin, 2kg of maltodextrin and 0.2kg of ascorbic acid into 10kg of purified water, stir and dissolve in a water bath at 60°C to obtain an aqueous phase;

[0032] Stir and melt 1kg lutein ester, 0.1kg sunflower oil and 0.2kg vitamin E in a 70°C water bath to obtain the oil phase;

[0033] 2) Slowly add the oil phase into the water phase for high-shear emulsification with a linear velocity of 12m / s; the particle size of the emulsion after emulsification is 0.23μm;

[0034] 3) Degassing treatment is carried out under a vacuum degree of 2 Pa;

[0035] 4) One-step granulation of the defoamed emulsion by a spray-fluidized bed drying method, the spray drying conditions are: air inlet temperature 90°C, fluidized bed blast temperature 90°C; the obtained lutein ester particles;

[0036] 5) Further embedding the lutein ester particles with 45% g...

Embodiment 2

[0038] This embodiment relates to a preparation method of a lutein ester preparation, comprising the following steps:

[0039] 1) Add 20kg of gelatin, 30kg of sucrose and 2kg of ascorbic acid into 10kg of purified water, stir and dissolve in a water bath at 60°C to obtain an aqueous phase;

[0040] Stir and melt 1kg lutein ester, 0.1kg sunflower oil and 0.2kg vitamin E in a 70°C water bath to obtain the oil phase;

[0041] 2) Slowly add the oil phase into the water phase for high-shear emulsification with a linear velocity of 12m / s; the particle size of the emulsion after emulsification is 0.18μm;

[0042] 3) Degassing treatment is carried out under a vacuum degree of 5 Pa;

[0043] 4) The defoamed emulsion is subjected to one-step granulation by a spray-fluidized bed drying method, and the spray drying conditions are: the inlet air temperature is 100°C, and the fluidized bed blast temperature is 100°C;

[0044] 5) The obtained particles were further embedded in 40% gelatin ...

Embodiment 3

[0046] This embodiment relates to a preparation method of a lutein ester preparation, comprising the following steps:

[0047] 1) Add 0.2kg of gelatin, 0.3kg of sucrose and 0.5kg of ascorbic acid into 1kg of purified water, stir and dissolve in a water bath at 80°C to obtain an aqueous phase;

[0048] Stir and melt 0.1kg lutein ester, 0.02kg sunflower oil and 0.05kg vitamin E in an 80°C water bath to obtain the oil phase;

[0049] 2) Slowly add the oil phase into the water phase for high-shear emulsification with a line speed of 8m / s; the particle size of the emulsion after emulsification is 0.28μm;

[0050] 3) Degassing treatment is carried out under a vacuum degree of 10 Pa;

[0051] 4) The defoamed emulsion is subjected to one-step granulation by a spray-fluidized bed drying method, and the spray drying conditions are: the inlet air temperature is 100°C, and the fluidized bed blast temperature is 95°C;

[0052] 5) The obtained microparticles were further embedded with 50%...

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Abstract

The invention belongs to the technical field of new resource food, and particularly relates to a lutein ester preparation for tabletting and a preparation method of the lutein ester preparation. The method comprises the following steps: 1) mixing a wall material, a filler and a water-based antioxidant with water, dissolving to obtain a water phase, and heating and melting lutein ester, an oil-soluble emulsifier and an oil-based antioxidant to obtain an oil phase; 2) mixing the oil phase and the water phase, and carrying out high-speed shearing emulsification; (3) carrying out vacuum defoaming treatment on the emulsion obtained after emulsification; (4) carrying out spray granulation on the emulsion obtained after vacuum defoaming treatment by using a spray-fluidized bed drying method; and 5) embedding the particles obtained by spray granulation by using a packing material solution through centrifugal granulation to obtain the lutein ester preparation. The lutein ester preparation prepared by the method provided by the invention has the advantages of few hollow structures, strong pressure resistance, good product stability, no leakage of the core material in the tabletting process, and long retention period.

Description

technical field [0001] The invention belongs to the technical field of new resource food, and in particular relates to a lutein ester preparation for tableting and a preparation method thereof. Background technique [0002] Lutein esters are carotenoid fatty acid esters in the form of lutein and fatty acids. It widely exists in marigold, cabbage corn and other plants, especially in marigold with the highest content. It can absorb blue light that is harmful to the retina, and has anti-oxidation effects, and plays an important role in the prevention and treatment of age-related macular degeneration and cataract diseases. [0003] Lutein crystals are difficult to emulsify due to their special property of being insoluble in oil and water. In order to improve stability and expand its application range, lutein ester microcapsules have been developed at home and abroad. Since lutein esters are wrapped in continuous capsules In the tiny capsule formed by the material, it avoids di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L2/39A23L33/105A23P10/30A23G3/36A23G3/48
CPCA23L2/39A23L33/105A23P10/30A23G3/364A23G3/48A23V2002/00A23V2200/30A23V2250/21A23V2250/5432A23V2250/5114A23V2250/708A23V2250/712A23V2250/628
Inventor 贾新超徐建中高伟孙金芝
Owner CHENGUANG BIOTECH GRP CO LTD
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