Continuous crystallization micro-nano chemical chip and application thereof

A chemical and micro-nano technology, applied in the field of continuous crystallization of micro-nano chemical chips, can solve problems such as inability to realize continuous production of products, product quality differences between batches, and damage to crystallization devices, so as to facilitate crystallization, improve crystal quality, and prevent Effects of deposition and clogging

Active Publication Date: 2021-09-03
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004]One purpose of the present invention is to solve the problem that the existing batch crystallization method cannot realize the continuous production of products and the quality of products varies between batches
[0005]Another object of the present invention is to solve the problem that the existing crystallization technology cannot be quickly applied to industrial production based on experimental results, and there is a "magnification effect"
[0006] Another purpose of the present invention is to solve the problem that crystal fouling and blockage easily occur on the inner wall of the channel or pipeline in the existing continuous crystallization technology, and damage the crystallization device

Method used

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  • Continuous crystallization micro-nano chemical chip and application thereof
  • Continuous crystallization micro-nano chemical chip and application thereof
  • Continuous crystallization micro-nano chemical chip and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The micro-nano chemical chip is provided with two injection channels 11, such as figure 1 As shown, the liquid injection channel 11 on the left is 300 μm deep, 520 μm wide, and 10 mm long; the liquid injection channel 11 on the right is 300 μm deep, 520 μm wide, and 10 mm long; the liquid inlet channel 4 is 300 μm deep, 700 μm wide, and 25 mm long; continuous crystallization Section 3 is 300 μm deep, 800 μm wide, and 200 mm long. The mixing channel 12 is 2 mm long and includes 2 splitting units 121 and 2 recombining units 122 . The base plate and cover plate are made of 2 mm thick glass plates.

[0047] Step 1. First place the micro-nano chemical chip under the reaction condition of an ambient temperature of 20°C, and then inject a sodium hydroxide solution with a concentration of 4.5mol / L into the liquid injection channel 11 on the left at a flow rate of 0.01ml / min. The hydrochloric acid solution with a concentration of 4.5mol / L is injected into the injection channel 1...

Embodiment 2

[0052] The micro-nano chemical chip is provided with two liquid injection channels 11, and the schematic diagram of the structure is as follows: figure 2 As shown, the liquid injection channel 11 on the left is 200 μm deep, 800 μm wide, and 14 mm long; the liquid injection channel 11 on the right is 200 μm deep, 800 μm wide, and 14 mm long; the liquid inlet channel 4 is 200 μm deep, 800 μm wide, and 68 mm long; continuous crystallization Section 3 is 200 μm deep, 800 μm wide, and 1000 mm long. The mixing channel 12 is 5.6 mm long and includes 9 split units 121 and 9 recombination units 122 . The base plate and cover plate are 2 mm thick glass plates.

[0053] Step 1. First place the micro-nano chemical chip under the reaction conditions of an ambient temperature of 25°C, and then inject the dolutegravir sodium solution with a concentration of 0.01g / ml into the injection solution on the left at a flow rate of 0.05ml / min Channel 11, isopropanol is injected into the injection ch...

Embodiment 3

[0058] The micro-nano chemical chip is provided with two liquid injection channels 11, and the schematic diagram of the structure is as follows: figure 2 As shown, the liquid injection channel 11 on the left is 200 μm deep, 800 μm wide, and 14 mm long; the liquid injection channel 11 on the right is 200 μm deep, 800 μm wide, and 14 mm long; the liquid inlet channel 4 is 200 μm deep, 800 μm wide, and 68 mm long; continuous crystallization Section 3 is 200 μm deep, 800 μm wide, and 444 mm long. The mixing channel 12 is 5.6 mm long and includes 9 splitting units 121 and 9 recombining units 122 . The base plate and cover plate are 2 mm thick glass plates.

[0059] Step 1. First place the micro-nano chemical chip under the reaction conditions of an ambient temperature of 70°C, and then inject the dolutegravir solution with a concentration of 0.00865g / ml into the injection channel on the left at a flow rate of 0.05ml / min 11. Inject sodium hydroxide with a concentration of 0.019878g...

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Abstract

The invention discloses a continuous crystallization micro-nano chemical chip and application thereof. The micro-nano chemical chip comprises a substrate and a cover plate covering the substrate. The substrate is provided with a micro-mixing part for forming a supersaturated mixed stock solution; a micro-dispersion part which is communicated with the micro-mixing part, and is internally filled with a flowing continuous phase, wherein the continuous phase and the supersaturated mixed stock solution are converged at the micro-dispersion part, and the continuous phase generates acting force on the supersaturated mixed stock solution, so that the supersaturated mixed stock solution is sheared into monodispersion liquid drops; and a continuous crystallization part which has a preset length, and is used for providing a place for continuous crystallization of monodisperse liquid drops to form monodisperse liquid drops wrapping crystals, wherein a liquid film exists between the monodisperse liquid drops and the inner wall of the continuous crystallization part, and the liquid drops are not infiltrated with the inner wall of the continuous crystallization part. According to the micro-nano chemical chip, continuous crystallization can be realized, uniform and stable crystallization conditions are provided, and the situation that crystals are attached and deposited on the wall surfaces of the channels to block the channels is avoided.

Description

technical field [0001] The invention relates to the field of crystallization equipment and technical research, in particular to a continuous crystallization micro-nano chemical chip and its application. Background technique [0002] Crystallization is one of the basic chemical processes and an important link in the production of chemical products. The manufacture and production of many chemical products are inseparable from the crystallization process, such as various petrochemical products, inorganic salts, polymers, building materials, etc. Therefore, crystallization is an indispensable and important production process in modern industry. The crystals prepared by the traditional batch crystallization method have large particle size and uneven distribution. The increased grinding operation to reduce the crystal particle size will destroy the chemical bonds inside the crystal and affect its quality, such as drug crystals. And because the operating parameters such as materi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D9/02
CPCB01D9/0072B01D9/0063
Inventor 鲍博郭曜豪罗薇刘芬邱俊杰赵双良朱维平钱旭红
Owner EAST CHINA UNIV OF SCI & TECH
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