Crosslinked polymeric network and use thereof
A polymer, network technology, applied in the field of cross-linked polymer network, can solve the problem of lens wearer discomfort
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example 1
[0158] Preparation of hyaluronic acid (HA) and chondroitin sulfate (CS) cross-linked polymer network with 1,4-butanediol diglycidyl ether (BDDE) having the following general structure 1:
[0159]
[0160] To a 100 mL round bottom flask equipped with a magnetic stirrer was added 60 mL of (reverse osmosis) water and 3.00 g of HA (7.44 mmol based on disaccharide units) and 3.00 g of CS (6.01 mmol based on disaccharide units). The solution was then stirred for 15 hours to ensure complete dissolution of the material to provide a clear solution with a pH of 6.65. To this solution was added 1.2 mL of BDDE (6.25 mmol). After stirring for 15 minutes, the pH of the slightly cloudy solution was adjusted to 8.5 with 0.2 g of 10% by weight sodium hydroxide solution. After 24 hours, the reaction mixture was then poured into 900 mL of ethanol to produce a precipitate and filtered. The solid was washed with 3 x 100 mL of ethanol and dried under high vacuum for 24 hours to yield 4.6 g (77...
example 2
[0166] Preparation of crosslinked polymer networks of HA and CS with adipate dihydrazide (ADH) with the following structure 2:
[0167]
[0168] Into a 50 mL Erlenmeyer flask equipped with a stir bar was added 31.9 mL of (reverse osmosis) water and 1.50 g of HA (3.72 mmol, based on disaccharide units). In a separate Erlenmeyer flask equipped with a stir bar was added 31.9 mL of (reverse osmosis) water and 1.86 g of CS (3.72 mmol, based on disaccharide units). Both solutions were stirred for 15 hours to ensure complete dissolution of the material. To each solution was added 0.075 g (0.389 mmol) of N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride in 0.5 mL of (reverse osmosis) water. Each container was rinsed with 0.5 ml (reverse osmosis) water. The solution was allowed to stir for 5 minutes and then added to a 100 mL round bottom flask equipped with a stir bar. Each flask was rinsed with 2 mL (reverse osmosis) water. To this solution was added 0.062 g (0.353 ...
example 3
[0175] Preparation of linear HA mixed with a cross-linked polymer network of HA and CS.
[0176] The cross-linked polymer network of the HA-CS of Example 1 or 2 is further mixed with linear HA polymer chains having the desired weight average molecular weight, i.e., about 10,000 Da to about 3,000,000 Da, to produce a soft gel (with mixed Cross-linked HA-CS of HA chains) and then disintegrated using a high shear mixer, precipitated and dried. Alternatively, the cross-linked polymer network of the HA-CS of Example 1 or 2 was mixed with linear HA having the desired weight average molecular weight in a weight ratio of 1:1 to 1:20 (HA-CS:HA) in together, and then dissolved in water to produce a gel for further use in various applications.
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