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Quaternary ammonium salt polyphosphazene hydrogel wound dressing with active and passive dual antibacterial mechanisms and preparation method

A wound dressing and hydrogel technology, applied in bandages, medical science and other directions, can solve the problems of strong bacterial resistance and biotoxicity, and achieve synergistic antibacterial efficiency, good swelling ability, improved load capacity and sustained release ability. Effect

Active Publication Date: 2021-09-14
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, antibacterial performance is a key factor in evaluating wound dressings, which is mainly achieved by loading antibacterial drugs such as antibiotics, metal nanoparticles, biological extracts, etc. on hydrogel wound dressings, which often lead to bacterial resistance with strong biological toxicity
Infection control remains a major challenge in modern wound management, especially in the context of increasing numbers of resistant bacteria

Method used

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  • Quaternary ammonium salt polyphosphazene hydrogel wound dressing with active and passive dual antibacterial mechanisms and preparation method
  • Quaternary ammonium salt polyphosphazene hydrogel wound dressing with active and passive dual antibacterial mechanisms and preparation method
  • Quaternary ammonium salt polyphosphazene hydrogel wound dressing with active and passive dual antibacterial mechanisms and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 56.1 mg of poly(dimethyl-aminoethyl-allyl ammonium bromide) phosphazene and 543.2 mg of 1-vinyl-2-pyrrolidone were dissolved in 1401.3 mg of deionized water to obtain a mixed solution. After being fully dissolved, argon gas was continuously passed into the mixed solution for 30 minutes to remove the oxygen in the mixed solution, and then 5.9 mg of 2-hydroxy-4-(2-hydroxyethoxy)-2-methyl was added to the mixed solution Propiophenone and fully dissolved to obtain a gel precursor solution.

[0041] The gel precursor solution was injected into the block mold (length = 1cm, width = 1cm, height = 1mm) and the columnar mold (inner diameter = 1cm), and then both the block mold and the columnar mold were placed under a 100W ultraviolet lamp for photoinitiation. Based polymerization reaction, the reaction lasted 30min. After the reaction, sheet-like and column-like organogels using deionized water as a solvent are obtained.

[0042] Take the sheet-shaped and columnar organogels ...

Embodiment 2

[0049] Poly(dimethyl-aminoethyl-allyl ammonium bromide) phosphazene 104.1 mg, 1-vinyl-2-pyrrolidone 495.5 mg, dissolved in 1400.5 mg deionized water to obtain a mixed solution. After being fully dissolved, argon gas was continuously passed into the mixed solution for 30 minutes to remove the oxygen in the mixed solution, and then 6.3 mg of 2-hydroxyl-4-(2-hydroxyethoxy)-2-methyl was added to the mixed solution Propiophenone and fully dissolved to obtain a gel precursor solution.

[0050] The gel precursor solution was injected into the block mold (length = 1cm, width = 1cm, height = 1mm) and the columnar mold (inner diameter = 1cm), and then both the block mold and the columnar mold were placed under a 100W ultraviolet lamp for photoinitiation. Based polymerization reaction, the reaction lasted 30min. After the reaction, sheet-like and column-like organogels using deionized water as a solvent are obtained.

[0051] The resulting sheet and columnar hydrogels were placed in st...

Embodiment 3

[0057] 141.1 mg of poly(dimethyl-aminoethyl-allyl ammonium bromide) phosphazene, 460.5 mg of 1-vinyl-2-pyrrolidone were dissolved in 1402.5 mg of deionized water to obtain a mixed solution. After being fully dissolved, argon gas was continuously passed into the mixed solution for 30 minutes to remove the oxygen in the mixed solution, and then 6.0 mg of 2-hydroxyl-4-(2-hydroxyethoxy)-2-methyl was added to the mixed solution Propiophenone and fully dissolved to obtain a gel precursor solution.

[0058] The gel precursor solution was injected into the block mold (length = 1cm, width = 1cm, height = 1mm) and the columnar mold (inner diameter = 1cm), and then both the block mold and the columnar mold were placed under a 100W ultraviolet lamp for photoinitiation. Based polymerization reaction, the reaction lasted 30min. After the reaction, sheet-like and column-like organogels using deionized water as a solvent are obtained.

[0059] Take the sheet-shaped and columnar organogels o...

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Abstract

The invention discloses a quaternary ammonium salt polyphosphazene hydrogel wound dressing with active and passive dual antibacterial mechanisms and a preparation method. The hydrogel wound dressing is obtained by free radical copolymerization of hydrophilic polyphosphazene containing quaternary ammonium salt functional groups and hydrophilic 1-vinyl-2-pyrrolidone in the presence of an initiator. The hydrogel wound dressing realizes passive contact antibacterial through cationic quaternary ammonium salt functional groups in a cross-linked skeleton, and a hydrogel network capable of being complexed with free iodine in the skeleton realizes free iodine loading and long-acting drug release; and the hydrogel wound dressing can realize the antibacterial purpose, has good swelling property, and has relatively high mechanical strength and relatively low hemolysis rate.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and relates to a hydrogel wound dressing and a preparation method thereof, in particular to a quaternary ammonium polyphosphazene hydrogel wound dressing with active and passive antibacterial mechanisms and a preparation method thereof. Background technique [0002] Chronic wounds require frequent dressing changes and are associated with infection, pain, and exudate problems, posing serious health risks to the human body. The development of wound infection can lead to the deterioration of granulation tissue, growth factors and extracellular matrix components, impairing the normal wound healing process. Therefore, the development of more economical, safe and efficient anti-infection wound dressings has become a medical and health concern. Wet dressings speed up the wound healing process compared to traditional dry dressings. According to the physical form, it can be divided into ointme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08F271/00C08F226/10C08F2/48C08J3/075C08L51/00
CPCA61L26/008A61L26/0066A61L26/0014A61L26/0061C08F271/00C08F2/48C08J3/075A61L2300/106A61L2300/208A61L2300/404A61L2300/45A61L2300/602C08J2351/00C08L51/00C08F226/10
Inventor 俞豪杰倪志鹏王立
Owner ZHEJIANG UNIV
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