Hedgehog-shaped catalytic material with atomic catalytic center and application of hedgehog-shaped catalytic material in preparation of antibacterial drugs

A technology of catalytic materials and antibacterial drugs, applied in antibacterial drugs, wave energy or particle radiation treatment materials, medical preparations containing active ingredients, etc., can solve the problems of limited bacterial capture ability and poor cytotoxicity, and achieve the goal of promoting wound healing. Effects of healing, good antibacterial activity

Active Publication Date: 2021-09-21
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it has been reported that V 2 o 5 The nanorods showed good HClO production and imitation haloperoxidase (HPO) activity, but V 2 o 5 Potential cytotoxicity and poor bacterial capture ability limit its application

Method used

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  • Hedgehog-shaped catalytic material with atomic catalytic center and application of hedgehog-shaped catalytic material in preparation of antibacterial drugs
  • Hedgehog-shaped catalytic material with atomic catalytic center and application of hedgehog-shaped catalytic material in preparation of antibacterial drugs
  • Hedgehog-shaped catalytic material with atomic catalytic center and application of hedgehog-shaped catalytic material in preparation of antibacterial drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Example 1 Preparation of hedgehog-like catalytic material Fe-Art M with atomic catalytic center

[0068] 1. Preparation of hedgehog-like metal-organic framework Atr M

[0069]50 mL of methanol containing zinc acetate dihydrate (0.22 g, 1 mmol) was mixed with 20 mL of methanol containing 2,5-dihydroxyterephthalic acid (60 mg, 0.3 mmol), and the resulting mixture was sonicated for 30 minutes. Then centrifuged to get the precipitate, and after washing with water three times, Zn-MOF-74 was obtained.

[0070] The obtained Zn-MOF-74 and 75 mL of deionized water containing urea (25 mg, 0.42 mmol) were added into a Teflon autoclave, and reacted at 175° C. for 24 hours. Then the obtained precipitate was washed with water and ethanol, respectively, and dried at 80° C. for 5 h under vacuum. Then, the obtained product was transferred to a ceramic boat and placed in a tube furnace, heated to 1100 °C at a heating rate of 5 °C / min for 1 h, and then naturally cooled to room temperatu...

Embodiment 2

[0073] Example 2 Preparation of hedgehog-like catalytic material V-Art M with atomic catalytic center

[0074] With reference to the preparation method of Example 1, the only difference is that the metal acetyl salt in step 2 is replaced by iron (III) acetylacetonate by vanadium (III) acetylacetonate to prepare a hedgehog-shaped catalytic material with an atomic catalytic center, which is the present invention Artificial macrophage V-Art M with atomic catalytic center.

[0075] Beneficial effects proved by the following experimental examples.

experiment example 1

[0076] Experimental Example 1 Structural Characterization

[0077] 1. Test samples

[0078] The target product Fe-Art M obtained in Example 1, the target product V-Art M obtained in Example 2, and the Atr M obtained in Step 1 of Example 1.

[0079] 2. Experimental method

[0080] On a TriStar 3020 accelerated surface area and porosimeter equipped with automatic surface area, N 2 Adsorption analysis, calculation of the surface area and pore size distribution of the material to be tested. X-ray photoelectron spectroscopy (XPS) was obtained by XPS equipment (ESCAL 250) to detect the composition of M-Art M and confirm the successful introduction of metals. Scanning electron microscope (SEM) images were acquired using Apreo S HiVoc (Thermo Fisher Scientific, FEI). Transmission electron microscope (TEM) images and maps were acquired with a Talos F200x TEM microscope (FEI Ltd., USA) operated at 200 kV. X-ray diffraction (XRD) patterns by Bruker D8 Focus X-ray diffractometer show...

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Abstract

The invention provides a hedgehog-shaped catalytic material with an atomic catalytic center and application of the hedgehog-shaped catalytic material in preparation of antibacterial drugs, and belongs to the field of antibacterial drugs. The hedgehog-shaped catalytic material with the atomic catalytic center is obtained by mixing a hedgehog-shaped metal organic framework material with metal salt and a material with pyridine N and then carrying out heat treatment. The material can be used for killing drug-resistant bacteria MRSA by simulating a 'capturing and killing' process of macrophages, and also has good mimic oxidase activity, mimic peroxidase activity and mimic halogen peroxidase activity. The material not only has good antibacterial activity on drug-resistant bacteria MRSA in vitro, but also can quickly promote healing of animal skin wounds infected by the MRSA bacteria in vivo. The hedgehog-shaped catalytic material provided by the invention is a non-antibiotic material, has excellent biocompatibility, can solve the problem of bacterial drug resistance caused by antibiotic abuse, and has wide application prospects in preparation of biomimetic materials simulating macrophages and antibacterial drugs.

Description

technical field [0001] The invention belongs to the field of antibacterial drugs, and in particular relates to a hedgehog-like catalytic material with an atomic catalytic center and its application in the preparation of antibacterial drugs. Background technique [0002] As we all know, bacterial drug resistance has become a major public health problem worldwide, and the abuse of antibiotics is an important reason for bacterial drug resistance. Methicillin-resistant Staphylococcus aureus (MRSA) has multidrug resistance and is associated with high morbidity and mortality. It is the leading cause of necrotizing pneumonia, severe sepsis, and necrotizing fasciitis The important pathogenic bacteria of the disease is one of the important pathogenic bacteria of hospital infection and community infection, which brings great difficulties to clinical treatment. MRSA is resistant to most antibacterial drugs or preparations, and even vancomycin, which is the most effective clinical anti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J31/22A61K41/00A61K33/26A61K33/24A61K33/40A61P31/04A61P17/02
CPCB01J31/1691B01J31/223A61K41/0057A61K33/26A61K33/24A61K33/40A61P31/04A61P17/02B01J2531/26A61K2300/00
Inventor 赵长生龙艳萍程冲马朗曹素娇马田李爽陈帆何超周密
Owner SICHUAN UNIV
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