Pharmaceutical composition for specifically regulating activity of hypothalamic ventral nucleus astrocyte and application of pharmaceutical composition

A technology of astrocytes and compositions, applied in the field of biomedicine, can solve the problems of excitotoxicity, stimulation, physical damage, etc., and achieve the effect of unique practicability, long onset time and small damage
CN113456646APending Publication Date: 2021-10-01SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
Publication Date
2021-10-01

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Abstract

The invention provides a pharmaceutical composition for specifically regulating activity of hypothalamic ventral nucleus astrocytes and application of the pharmaceutical composition. The pharmaceutical composition comprises clozapine nitrogen oxide and a viral vector used for infecting the astrocytes; the viral vector comprises a pharmaceutical genetics regulatory element hM4Di or hM3Dq. The pharmaceutical composition can selectively activate a Gi pathway or a Gq pathway of astrocytes, and by means of the pharmaceutical composition. According to the invention, it is proved that anxiety-like behaviors and bone loss phenomena induced by chronic pressure stress can be intervened by selectively adjusting the activity of VMH astrocytes.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and specifically relates to a pharmaceutical composition for specifically regulating the activity of astrocytes in the ventromedial nucleus of the hypothalamus and an application thereof. Background technique

[0002] Research evidence shows that nervous system function and bone metabolism are interrelated. Combined with a large amount of experimental data, some researchers have proposed that all organs maintain the overall physiological function balance through organ talk; bone growth, metabolism and remodeling are regulated by multiple organs in the body, and bone metabolism itself also affects It affects the function of several vital organs including the brain, gonads and digestive system.

[0003] In addition, a large number of research data show that anxiety and depression are closely related to bone loss, but the underlying mechanism is still unclear. And through case correlation anal...

Claims

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