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Targeted drug of chemical kinetics enhanced photothermal therapy system for treating malignant tumors, and preparation method and application of targeted drug

A technology of chemical kinetics and photothermal therapy, which is applied in the direction of antineoplastic drugs, drug combinations, and pharmaceutical formulations, can solve the problems of easy recurrence, easy metastasis, and incomplete removal, and achieve the goal of inhibiting recurrence and metastasis and efficiently removing tumors Effect

Active Publication Date: 2021-10-01
WENZHOU MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the problems of incomplete removal, easy metastasis and easy recurrence in the treatment of malignant tumors in clinical practice, the present invention provides a targeted drug of a chemokinetic enhanced photothermal therapy system for the treatment of malignant tumors and its preparation method and application. Through excellent photothermal conversion characteristics and Fenton-like reaction catalytic activity, it achieves a high killing rate for malignant tumor tissues and a high inhibition rate for residual tumor recurrence and metastasis, providing a convenient clinical treatment for malignant tumors Efficient new ideas

Method used

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  • Targeted drug of chemical kinetics enhanced photothermal therapy system for treating malignant tumors, and preparation method and application of targeted drug
  • Targeted drug of chemical kinetics enhanced photothermal therapy system for treating malignant tumors, and preparation method and application of targeted drug
  • Targeted drug of chemical kinetics enhanced photothermal therapy system for treating malignant tumors, and preparation method and application of targeted drug

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Embodiment 1

[0028] A heteroatom-doped graphene nano-bionic enzyme (H-GPP / G), the preparation of which comprises the following steps: as figure 1 As shown, mPEG-COOH activates its carboxyl group under the catalysis of EDC and NHS, and the activated mPEG-COOH is added to a heteroatom-containing polymer (HP) such as polyethyleneimine solution (molar ratio 1:1 ~ 1: 5), stirring and reacting for 12-24 h. After HP-PEG dialysis and purification, the obtained product was mixed with graphene oxide powder (GO) at a mass ratio of 1:1 to 1:3, placed in a ball mill jar, and ball milled at room temperature for 2 to 4 h at a speed of 300 to 500 rpm. , and the precipitate was collected by centrifugation to obtain H-GPP. Finally, H-GPP and GOD were mixed and incubated to obtain the final H-GPP / G nano-bionic enzyme.

Embodiment 2

[0030] Such as figure 2 As shown, the prepared H-GPP / G presents an obvious lamellar composite structure, the nanoparticles are uniformly distributed on the graphene sheet, the overall size is about 200 nm, and the thickness of graphene is about 1.5 nm. The particle thickness is about 2.9 nm.

Embodiment 3

[0032] Such as image 3 As shown, the H-GPP prepared by the present invention is at 808 nm (1.2 W / cm 2 ) after 5 min of laser irradiation, with the increase of GPP concentration, the heating effect gradually increased. When the concentration was 500 μg / mL, the temperature rose from 28°C to 72°C. Under the same conditions, the water temperature of the control group tended to be stable. This confirms that the H-GPP prepared in the present invention has excellent light-to-heat conversion performance.

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Abstract

The invention relates to a targeted drug of a chemical kinetics enhanced photothermal therapy system for treating malignant tumors, and a preparation method and application of the targeted drug. According to the invention, a non-metal hybrid doped graphene nanometer bionic enzyme system is designed on the basis of challenges that the malignant tumors are difficult to remove thoroughly, easy to relapse and transfer and the like, is hopeful to efficiently remove tumors and inhibit reoccurrence and metastasis of residual tumors through a CDT enhanced PTT effect, and provides a new solution idea is for clinical treatment of serious malignant tumors.

Description

technical field [0001] The invention relates to the preparation of non-metallic nano-bionic enzymes and its application in the field of anti-tumor technology such as combined photothermal and chemical kinetic therapy, in particular to a targeted drug for a chemical kinetic enhanced photothermal therapy system for treating malignant tumors and its preparation Methods and applications. Background technique [0002] Malignant tumors (such as breast cancer) seriously threaten human health and life. Although the treatment techniques for malignant tumors are constantly updated, their long-term survival rate has not been significantly improved, and the recurrence and metastasis of tumor prognosis are the main reasons for the lower survival rate in the later stage. Currently, there is no effective treatment plan for postoperative metastasis and recurrence of malignant tumors in clinical practice. Therefore, preventing or blocking tumor recurrence and metastasis is a key challenge t...

Claims

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Application Information

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IPC IPC(8): A61K33/44A61K41/00A61K47/60A61P35/00A61P35/04
CPCA61K41/0052A61K33/44A61K47/60A61P35/00A61P35/04A61K2300/00Y02A50/30
Inventor 刘勇孔令丹袁峰黄萍萍晏露
Owner WENZHOU MEDICAL UNIV
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