Wound hemostasis composite material as well as preparation method and application thereof

A composite material and wound technology, applied in the treatment of skin, equipped with a handheld electrospinning instrument, can solve the problems of low hemostasis, limited healing ability, poor mechanical properties, etc., to promote the formation of blood vessels, promote wound healing, The effect of strong adhesion

Active Publication Date: 2021-10-08
QUANZHOU NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Bleeding from accidental injury or surgical operation may cause many health risks, and may be fatal in severe cases. Therefore, it is urgent to develop hemostatic materials or methods, because most Hemostatic methods are passive interactions, such as bandages, tourniquets, gels, etc., none of which can actively stop bleeding, and long-term use of tourniquets can lead to serious complications, such as ischemia-reperfusion injury, which can lead to muscle necrosis or even amputation
[0003] Existing hemostatic materials have problems such as low hemostatic ability, poor mechanical properties, limited healing ability, and high manufacturing cost, which limit the application of their reagents

Method used

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  • Wound hemostasis composite material as well as preparation method and application thereof
  • Wound hemostasis composite material as well as preparation method and application thereof
  • Wound hemostasis composite material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Soak discarded egg shell membranes in 0.02 M HCl for 12 h, wash them with distilled water until neutral, take them out, dry them, grind them, and place them in 0.02 M NaOH solution for 3 h to obtain 2 wt% eggshell membrane solution.

[0029] (2) Dissolve chitosan with a deacetylation degree greater than 70% in acetic acid to obtain a 2 wt% chitosan solution to ensure the high molecular weight and high viscosity of chitosan.

[0030] (3) Egg membrane was used as raw material, dissolved in citric acid, placed in a 160 °C environment for 5 h, filtered, centrifuged, and diluted to obtain a 1 wt% carbon dot solution after the reaction, and set aside.

[0031] (4) Put the washed eggshells in a ball mill (100 g), grind the eggshells into powder by water milling method for 3 hours, take out the eggshell powder, wash and dry for later use.

[0032] (5) Dissolve PVP in an appropriate amount of ethanol and stir for 2 h to form a uniform 15 wt% PVP ethanol solution.

[0033] ...

Embodiment 2

[0038] (1) Soak discarded egg shell membranes in 0.04 M HCl for 18 h, wash them with distilled water until neutral, take them out, dry them, grind them, and place them in 0.04 M NaOH solution for 4 h to obtain eggshell membranes solution (2 wt%).

[0039](2) Dissolve chitosan with a deacetylation degree greater than 70% in acetic acid to obtain a 2 wt% chitosan solution to ensure the high molecular weight and high viscosity of chitosan.

[0040] (3) Egg membrane was used as raw material, dissolved in citric acid, placed in a 180 °C environment for 8 h, and after the reaction was completed, it was filtered, centrifuged, and diluted to obtain a 2 wt% carbon dot solution for future use.

[0041] (4) Put the washed eggshells (100 g) in a ball mill, and grind the eggshells into powder by water milling for 5 hours. Take out the eggshell powder, wash and dry for later use.

[0042] (5) Dissolve PVP in ethanol and stir for 2 h to form a uniform 15 wt% PVP ethanol solution.

[0043] ...

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PUM

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Abstract

The invention belongs to the technical field of medical materials, and particularly relates to a preparation method and application of a wound hemostasis composite material. The wound hemostasis composite material is prepared by taking waste egg membranes as raw materials, chitosan as an antibacterial agent, carbon dots as a hemostasis enhancer, an antioxidant and a fluorescence emitting agent, and eggshell powder as an angiogenesis accelerant and a biological mineralizer. The composite material has excellent antibacterial performance and can effectively kill pathogenic bacteria near a wound and prevent wound infection; and meanwhile, the composite material has hemostatic performance and angiogenesis promoting performance, can effectively stop bleeding and promote angiogenesis, and is easy in collection of preparation materials, simple in preparation process and equipment requirements, free of environmental pollution, easy to degrade and low in cost.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a preparation method of a hemostatic composition using waste eggshell membrane as a raw material and a hand-held electrospinning apparatus for skin treatment. Background technique [0002] Bleeding from accidental injury or surgery may cause many health risks, and may be fatal in severe cases. Therefore, it is urgent to develop hemostatic materials or methods, because most hemostatic methods are passive interactions, such as bandages, tourniquets, coagulation, etc. They cannot actively stop bleeding, and long-term use of tourniquets can lead to serious complications, such as ischemia-reperfusion injury, which can lead to muscle necrosis and even amputation. [0003] Existing hemostatic materials have problems such as low hemostatic ability, poor mechanical properties, limited healing ability, and high manufacturing cost, which limit the application of their ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F4/00A61L24/00A61L24/02A61L24/08D01F1/10
CPCD01F4/00D01F1/103D01F1/10A61L24/08A61L24/0005A61L24/02A61L24/0015A61L2400/04A61L2300/404A61L2300/236A61L2300/108A61L2300/412A61L2300/418A61L2300/45C08L5/08
Inventor 刘明焕付博飞杨大鹏焦福星刘凯李志悦施伟章
Owner QUANZHOU NORMAL UNIV
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