Preparation method for extracting total flavonoids from peony flowers

A technology of peony flower and total flavonoids, which is applied in skin care preparations, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problem of high extraction bottle placement requirements, unfavorable large-scale production, and the impact of peony flavonoid activity and other problems, to achieve the effect of being suitable for large-scale production, easy to operate, and good extraction effect

Active Publication Date: 2021-10-19
ZHEJIANG YIGE ENTERPRISE MANAGEMENT GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the organic solvent method uses methanol or ethanol as the solvent, and there is a risk of solvent residue; while the enzymatic extraction takes a long time and requires a high temperature condition for a long time, which has high requirements for temperature, wastes energy, and is not conducive to large-scale Production, and also has an impact on the activity of peony flavonoids; ultrasonic extraction can be carried out at room temperature, with high extraction rate and low energy consumption, but when the sample volume is large, the ultrasonic energy reaching the inside of the sample is severely attenuated, the extraction effect is poor, and the amount of sample used For a long time, the accumulation thickness increases, and the extraction effect of the reagent on the inside of the sample is insufficient, which affects the extraction effect, and ultrasonic extraction has high requirements for the thickness of the extraction bottle and the placement of the extraction bottle, which affects the extraction effect

Method used

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  • Preparation method for extracting total flavonoids from peony flowers
  • Preparation method for extracting total flavonoids from peony flowers

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Experimental program
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Effect test

Embodiment 1

[0024] A preparation method for extracting total flavonoids from peony flowers, comprising the following steps:

[0025] S1, take the dried peony flower, remove impurities, pulverize, and obtain the peony flower powder as product A;

[0026] S2, mix product A and 1,3-propanediol with a mass ratio of 10:1-20:1 to obtain product B;

[0027] S3. Pass product B through supercritical CO 2 extraction, initial extraction, CO 2 The flow rate is 8-12L / h, the extraction pressure is 25-35MPa, the extraction temperature is 30-32℃, and the extraction time is 8-12min; then increase the CO 2 The flow rate is increased to 20-30L / h, the extraction pressure is increased to 45-55MPa at a rate of 0.3-0.6MPa per minute, the extraction temperature is kept at 30-32°C, and the extraction time is 45-55min to obtain C product;

[0028] S4. Separate product C, the separation pressure is reduced to 2-8MPa at a rate of 0.4-0.6MPa per minute, and the separation temperature is 25-30°C to obtain a finishe...

Embodiment 2

[0030] A preparation method for extracting total flavonoids from peony flowers, comprising the following steps:

[0031] S1, take the dried peony flower, remove impurities, pulverize and pass through a 40-50 mesh sieve, and obtain the peony flower powder as product A;

[0032] S2, mix product A and 1,3-propanediol with a mass ratio of 10:1 to obtain product B;

[0033] S3. Pass product B through supercritical CO 2 extraction, initial extraction, CO 2 The flow rate is 8L / h, the extraction pressure is 25MPa, the extraction temperature is 30℃, and the extraction time is 8min; then increase the CO 2 The flow rate was increased to 20L / h, the extraction pressure was increased to 45MPa at a rate of 0.3MPa per minute, the extraction temperature was kept at 30°C, and the extraction time was 45min to obtain C product;

[0034] S4. Separate product C, the separation pressure is reduced to 8MPa at a rate of 0.4MPa per minute, and the separation temperature is 25°C to obtain a finished ...

Embodiment 3

[0036] A preparation method for extracting total flavonoids from peony flowers, comprising the following steps:

[0037] S1, get the dried peony flower, remove impurities, pulverize and pass through a 50-mesh sieve, and obtain the peony flower powder as product A;

[0038] S2. Mix product A and 1,3-propanediol with a mass ratio of 15:1 to obtain product B;

[0039] S3. Pass product B through supercritical CO 2 extraction, initial extraction, CO 2 The flow rate is 12L / h, the extraction pressure is 35MPa, the extraction temperature is 32℃, and the extraction time is 12min; then increase the CO 2 The flow rate was increased to 30L / h, the extraction pressure was increased to 55MPa at a rate of 0.6MPa per minute, the extraction temperature was kept at 32°C, and the extraction time was 55min to obtain C product;

[0040] S4. Separate product C, the separation pressure is reduced to 2MPa at a rate of 0.6MPa per minute, and the separation temperature is 30°C to obtain a finished pr...

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PUM

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Abstract

The invention discloses a preparation method for extracting total flavonoids from peony flowers. The preparation metho comprises the following steps: S1, weighing dried peony flowers, removing impurities, and conducting crushing to obtain peony flower powder as a product A; S2, uniformly mixing the product A and 1,3-propyleneglycol to obtain a product B; S3, subjecting the product B to supercritical CO2 extraction, wherein the flow of CO2 is 8-12 L/h, extraction pressure is 25-35 MPa, an extraction temperature is 30-32 DEG C and extraction time is 8-12 min, then increasing the flow rate of CO2 to 20-30 L/h, increasing the extraction pressure to 45-55 MPa at a speed of 0.3-0.6 MPa per minute, and keeping the extraction temperature at 30-32 DEG C and conducting extraction for 45-55 min to obtain a product C; and S4, separating the product C to obtain a finished product. The method has the characteristics that the extraction yield of the total flavonoids is increased, the activity of effective components of the total flavonoids is ensured, requirements on extraction conditions are low, and operation is easy.

Description

technical field [0001] The invention relates to the extraction of effective components from plants, in particular to a preparation method for extracting total flavonoids from peony flowers. Background technique [0002] Peony is a rare and unique flower in China, and has the reputation of "national beauty and heavenly fragrance". The active ingredients of peony flower extract are mainly peony pigments, flavonoids, plant essential oils and amino acid mixtures. Among them, peony flower flavonoids have the greatest effect on skin care, and total flavonoids of peony have good antioxidant and whitening effects, which can effectively remove hydroxyl radicals and oxygen free radicals, and resist skin aging. Peony flower extract can be widely used in functional skin care products. [0003] In the prior art, the extraction techniques for total flavonoids in peony flowers are mainly organic solvent alcohol extraction method, enzymatic method and ultrasonic extraction method. Among ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07G99/00A61K8/9789A61Q19/00A61Q19/02A61Q19/08
CPCA61K8/9789A61Q19/08A61Q19/00A61Q19/02A61K2800/805C07G99/00Y02P20/54
Inventor 张大勇毕永贤周浩淼刘金俊李昊朱秀洁杜雨涵
Owner ZHEJIANG YIGE ENTERPRISE MANAGEMENT GRP CO LTD
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