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Submicron emulsion of propolis phospholipid complex and preparation method of submicron emulsion

A technology of sub-microemulsion and propolis phospholipid, applied in the field of pharmaceutical preparations, can solve the problems of inability to apply clinically, the anti-diabetic effect is not obvious, and the oral bioavailability of active ingredients is low, and the effect of improving the bioavailability and improving the stability is achieved.

Active Publication Date: 2021-10-29
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, commercially available propolis products are soft capsules and tablets. Due to the low oral bioavailability of the active ingredients, the anti-diabetic effect is not obvious, so they cannot be used clinically and are only used as health products.

Method used

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  • Submicron emulsion of propolis phospholipid complex and preparation method of submicron emulsion
  • Submicron emulsion of propolis phospholipid complex and preparation method of submicron emulsion
  • Submicron emulsion of propolis phospholipid complex and preparation method of submicron emulsion

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1: the preparation of propolis phospholipid complex

[0052] The propolis phospholipid complex is prepared by the following method: dissolving propolis extract and soybean lecithin in 500mL ethanol at a mass ratio of 1g:1g, reacting at 40°C for 2 hours, removing ethanol by rotary evaporation, and then freeze-drying ,be made of.

Embodiment 2

[0053] Embodiment 2: the preparation of submicroemulsion

[0054] A propolis phospholipid complex submicron emulsion, calculated by 100mL, comprising the following components: propolis phospholipid complex 3.0g; soybean oil 7.5g; medium chain triglyceride 7.5g; soybean lecithin 1.2g; Tween 80 1.0g ; Poloxamer 188 1.0g; Sodium Oleate 0.03g; Add water to 100mL.

[0055] A preparation method of submicroemulsion, comprising the following steps:

[0056] Step 1: Prepare the oil phase mixture: weigh the above-mentioned components according to the formula amount, heat the propolis phospholipid complex, soybean oil, and medium-chain triglyceride to 70° C. to dissolve, and obtain the oil phase mixture;

[0057] Step 2: preparing the aqueous phase mixture: stirring and mixing Tween 80, poloxamer 188, sodium oleate and water, heating to 70° C. to dissolve, and obtaining the aqueous phase mixture;

[0058] Step 3 to prepare submicron emulsion: add the oil phase mixture to the water phas...

Embodiment 3

[0060] Embodiment 3: the preparation of submicroemulsion

[0061] A propolis phospholipid complex submicron emulsion, calculated by 100mL, comprising the following components: propolis phospholipid complex 0.5g; soybean oil 5g; medium chain triglyceride 5g; egg yolk lecithin 1g; Tween 80 0.5g; Sham 188 0.5g; oleic acid 1.5g; add water to 100mL.

[0062] A preparation method of submicroemulsion, comprising the following steps:

[0063] Step 1: Prepare the oil phase mixture: weigh the above-mentioned components according to the formula, heat the propolis phospholipid complex, soybean oil, and medium-chain triglyceride to 80° C. to dissolve, and obtain the oil phase mixture;

[0064] Step 2: Prepare the aqueous phase mixture: stir and mix egg yolk lecithin, Tween 80, poloxamer 188, oleic acid and water, and heat to 80° C. to dissolve to obtain the aqueous phase mixture;

[0065] Step 3 preparation of submicron emulsion: adding the oil phase mixture to the water phase mixture, u...

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Abstract

The invention provides a submicron emulsion of a propolis phospholipid complex and a preparation method of the submicron emulsion. The submicron emulsion of the propolis phospholipid complex comprises an active ingredient: the propolis phospholipid complex; and a carrier comprising an oil phase, an emulsifier, a solubilizer, a stabilizer and water. A preparation process of the propolis phospholipid complex comprises the following steps: dissolving a propolis extract and phospholipid in an organic solvent, carrying out a reaction with heating, and removing the organic solvent, thereby obtaining the propolis phospholipid complex. According to the submicron emulsion of the propolis phospholipid complex and the preparation method of the submicron emulsion, the propolis extract and the phospholipid are utilized to form the propolis phospholipid complex, then, the propolis phospholipid compound is prepared into the submicron emulsion, after oral administration, the concentration of chrysin and galangin (characteristic flavone components of the propolis extract) in blood is rapidly increased, the bioavailability is remarkably improved, the anti-diabetes effect is similar to that of positive drugs, and the propolis phospholipid compound can be clinically used.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a submicron emulsion of propolis-phospholipid complex and a preparation method thereof. Background technique [0002] About 246 million people worldwide suffer from type 2 diabetes, and the course of the disease is increasing. Clinically, the treatment of type 2 diabetes is mainly based on oral hypoglycemic chemical drugs and insulin injections. Although traditional drug therapy has a significant hypoglycemic effect, long-term use can lead to patient tolerance, hypoglycemia, gastrointestinal discomfort, cardiovascular risk, or reduced patient compliance due to the inconvenience and pain of injections. [0003] Propolis is the gum collected by worker bees from the new buds or bark of trees and other plants, and mixed with bee mandibular gland secretions and beeswax to form a solid colloidal substance with aromatic stickiness. Its main components a...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K35/644A61K47/10A61K47/12A61K47/14A61K47/24A61K47/26A61K47/44A61P3/00A61P3/06A61P3/10A61P9/00A61P9/10
CPCA61K35/644A61K47/24A61K47/44A61K47/14A61K47/10A61K47/26A61K47/12A61K9/1075A61P9/00A61P3/00A61P3/10A61P9/10A61P3/06Y02A50/30
Inventor 秦凌浩
Owner GUANGDONG PHARMA UNIV
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