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Nano composite porous hydrogel as well as preparation and application thereof

A porous hydrogel and nanocomposite technology, used in bandages, drug delivery, pharmaceutical formulations, etc., can solve the problems of uneven pore size distribution of porous structures, biological toxicity, difficult to control pore size, etc., to achieve excellent blood coagulation and hemostasis performance, enhanced Effects of stability, good biocompatibility

Pending Publication Date: 2021-10-29
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the commonly used methods for preparing porous hydrogels include porogen method, freeze-drying method, emulsion template method, phase separation method, etc., but the pore size distribution of the porous structure prepared by the above methods is not uniform, it is difficult to control the pore size, and there is a certain biological toxicity

Method used

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  • Nano composite porous hydrogel as well as preparation and application thereof
  • Nano composite porous hydrogel as well as preparation and application thereof
  • Nano composite porous hydrogel as well as preparation and application thereof

Examples

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Embodiment 1

[0064] A method for preparing a nanocomposite porous hydrogel, comprising the steps of:

[0065] (1) Synthesis of GelDA (dopamine-grafted gelatin) using gelatin and dopamine hydrochloride

[0066] ① Weigh 2g of gelatin into a 250mL round bottom flask, add 100mL of MES buffer solution with a pH of 5.5, seal the container, stir at a constant speed of 250rpm, dissolve in a water bath at 50°C for 30 minutes until the gelatin in the flask is completely dissolved into a light yellow clear liquid, stop Heat to cool the gelatin solution to room temperature;

[0067] ②Add 500mg EDC and 300mg NHS to the solution obtained in step ①, and stir at a constant speed of 250rpm at room temperature until dissolved;

[0068] ③Seal the system, insert a long needle with nitrogen to the liquid level of the system, take another 5mL syringe needle and insert it on the rubber stopper to form a connection, stir at 250rpm to activate the carboxyl group for 30min at room temperature, and at the same time...

Embodiment 2

[0082] A method for preparing a nanocomposite porous hydrogel, comprising the steps of:

[0083] (1) Synthesis of GelDA (dopamine-grafted gelatin) using gelatin and dopamine hydrochloride

[0084] ① Weigh 2g of gelatin into a 250mL round bottom flask, add 100mL of MES buffer solution with a pH of 5.5, seal the container, stir at a constant speed of 250rpm, dissolve in a water bath at 50°C for 30 minutes until the gelatin in the flask is completely dissolved into a light yellow clear liquid, stop Heat to cool the gelatin solution to room temperature;

[0085] ②Add 500mg EDC and 300mg NHS to the solution obtained in step ①, and stir at a constant speed of 250rpm at room temperature until dissolved;

[0086] ③Seal the system, insert a long needle with nitrogen gas under the liquid level of the system, take another 5ml syringe needle and insert it on the rubber stopper to form a connection, at room temperature, stir at 250rpm to activate the carboxyl group for 30min, and at the s...

Embodiment 3

[0101] A method for preparing a nanocomposite porous hydrogel, comprising the steps of:

[0102] (1) Synthesis of GelDA (dopamine-grafted gelatin) using gelatin and dopamine hydrochloride

[0103] ① Weigh 2g of gelatin into a 250mL round bottom flask, add 100mL of MES buffer solution with a pH of 5.5, seal the container, stir at a constant speed of 250rpm, dissolve in a water bath at 50°C for 30 minutes until the gelatin in the flask is completely dissolved into a light yellow clear liquid, stop Heat to cool the gelatin solution to room temperature;

[0104] ②Add 500mg EDC and 300mg NHS to the solution obtained in step ①, and stir at a constant speed of 250rpm at room temperature until dissolved;

[0105] ③Seal the system, insert a long needle with nitrogen to the liquid level of the system, take another 5mL syringe needle and insert it on the rubber stopper to form a connection, stir at 250rpm to activate the carboxyl group for 30min at room temperature, and at the same time...

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Abstract

The invention discloses nano composite porous hydrogel as well as preparation and application thereof, and relates to the technical field of biomedical materials. The preparation method of the hydrogel comprises the following steps of: firstly synthesizing dopamine modified gelatin, taking methacrylic acid modified gelatin as an emulsion stabilizer and water as a continuous phase, stirring and dissolving a functional polymer dopamine modified gelatin, silicate nano-clay and a photoinitiator in the continuous phase at a high speed to obtain stable air-in-water composite hydrogel emulsion; and preparing the novel nano composite porous hydrogel with a three-dimensional network porous structure, good mechanical properties, biocompatibility and coagulation performance through ultraviolet-initiated polymerization. Multiple dynamic physical / chemical crosslinking among the components in the hydrogel endows the hydrogel with good mechanical properties and self-healing properties. The hydrogel has good adhesion performance and blood coagulation performance to tissues, can be used for rapid sealing and blood coagulation hemostasis of bleeding wounds so as to promote tissue repair, and is expected to be applied to the fields of biological medicines, tissue engineering and the like.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a nanocomposite porous hydrogel and its preparation and application. Background technique [0002] Fatal bleeding may be life-threatening, and the development of new and efficient hemostatic materials is of great significance for saving the lives and health of patients. Although a variety of coagulation and hemostasis materials have been developed, these materials have relatively single functions, often do not have good dynamic mechanical properties and rapid coagulation and hemostasis, and have no significant effect on hemostasis and repair of complex wounds. In addition, most materials have a single coagulation mechanism, which stops bleeding by adsorption or sealing, and lacks inherent coagulation properties. Therefore, it is of great significance to develop new hemostatic materials that are safe and efficient, have good dynamic mechanical properties, good adhesi...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J3/24C08L89/00C08K3/34A61L26/00
CPCC08J3/075C08J3/243A61L26/008A61L26/0095A61L26/0085A61L2400/04C08J2389/00C08J2489/00C08K3/346C08K2201/011C08L89/00
Inventor 陈云华谢曼珊浦仕恒
Owner SOUTH CHINA UNIV OF TECH
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