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Soluble microneedle patch for targeted diagnosis and treatment of skin diseases and preparation of soluble microneedle patch

A microneedle patch and microneedle array technology, applied in the field of biomedicine, can solve the problems of unsatisfactory curative effect, poor transdermal effect, uncontrollable drug metabolism behavior, etc. The effect of good biocompatibility

Pending Publication Date: 2021-11-02
HUAZHONG UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The nanoparticle medicine synthesized by the invention has a controllable particle size and self-fluorescent properties, which can realize real-time monitoring of the metabolic behavior of nanomedicine in the treatment of skin diseases, and solve the problem of the transdermal effect of nanomedicine in the treatment of skin diseases. Poor, uncontrollable drug metabolism behavior and unsatisfactory curative effect and other technical problems, provide data support and theoretical reference for others to design corresponding nano-drugs for the treatment of skin diseases, and solve a microneedle loaded with small-molecule nano-particle drugs Patch preparation issues

Method used

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  • Soluble microneedle patch for targeted diagnosis and treatment of skin diseases and preparation of soluble microneedle patch
  • Soluble microneedle patch for targeted diagnosis and treatment of skin diseases and preparation of soluble microneedle patch
  • Soluble microneedle patch for targeted diagnosis and treatment of skin diseases and preparation of soluble microneedle patch

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preparation example Construction

[0032] A method for preparing a microneedle patch for targeted diagnosis and treatment of skin diseases of the present invention, comprising the following steps:

[0033] 1) Prepare the microneedle array mold: mix PDMS (polydimethylsiloxane, Sylgard184) and curing agent at a ratio of 10:1, pour the mixture solution on the surface of the microneedle template, and remove the mixture by vacuuming at -0.08Mpa. Bubbles in the solution, and then put the mixture in an oven at 80°C to heat and solidify for 3-4 hours, take it out, and separate the solidified PDMS from the microneedle template after cooling to obtain a PDMS microneedle array mold;

[0034] 2) Preparation of self-assembled nano drug particles: Dissolve the therapeutic drug in the corresponding solvent, and dissolve the near-infrared dye IR783 in deionized water, and finally add the drug solution drop by drop into the near-infrared dye IR783 solution under stirring, and stir at room temperature After 30 minutes, the react...

Embodiment 1

[0051] The preparation of trametinib@IR783 self-assembled nanoparticle microneedle patch includes the following steps:

[0052] Step 1) Prepare the microneedle array mold: mix PDMS (polydimethylsiloxane, Sylgard184) and curing agent at a ratio of 10:1, and pour the mixture solution on the surface of the quadrangular pyramid microneedle array template. The specifications of the template are as follows: The height of any microneedle is 100 μm, and the base diameter is 100 μm; the distance between the tips of two adjacent needles is 200 μm, and the air bubbles in the mixed solution are removed by vacuuming at -0.08Mpa, and then the mixture is heated and solidified in an oven at 80°C Take it out after 3-4 hours, and after cooling, separate the solidified PDMS from the microneedle template to obtain the PDMS microneedle array mold;

[0053] Step 2) Preparation of trametinib@IR783 self-assembled nano-drug particles: Dissolve 20mg trametinib in 1mLDMSO, and dissolve 1mg IR783, a near...

Embodiment 2

[0057] The preparation of self-assembled nanoparticle microneedle patch loaded with Sorafenib@IR783 includes the following steps:

[0058] Step 1) Prepare the microneedle array mold: mix PDMS (polydimethylsiloxane, Sylgard184) and curing agent at a ratio of 10:1, and pour the mixture solution on the surface of the quadrangular pyramid microneedle array template. The specifications of the template are as follows: The height of any microneedle is 650 μm, and the base diameter is 200 μm; the distance between the tips of two adjacent needles is 500 μm, and the air bubbles in the mixed solution are removed by vacuuming at -0.08Mpa, and then the mixture is heated and solidified in an oven at 80°C Take it out after 3-4 hours, and after cooling, separate the solidified PDMS from the microneedle template to obtain the PDMS microneedle array mold;

[0059] Step 2) Preparation of Sorafenib@IR783 self-assembled nano drug particles: Dissolve 15mg Sorafenib in 1mLDMSO, and dissolve 1mg IR78...

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Abstract

The invention relates to a soluble microneedle patch for targeted diagnosis and treatment of skin diseases and preparation of the soluble microneedle patch, and belongs to the technical field of biological medicines. The patch comprises a base and polymer needle bodies, the polymer needle bodies are located on the base in an array mode, polymers forming the polymer needle bodies can be dissolved in water, and nano-drug particles are dispersed on the needle point parts of the polymer needle bodies. The preparation method comprises the following steps: treating a microneedle array female die by using oxygen plasma, so that the surface of the microneedle array female die is hydrophilic; and dripping the nano-drug solution on the surface of the microneedle array female die for centrifugal treatment, injecting the water-soluble polymer solution into the microneedle array female die, vacuumizing, drying, and stripping the microneedles from the female die to obtain the microneedle patch. The synthesized microneedle patch can realize real-time monitoring of metabolic behaviors of drug particles in skin disease treatment, and solves the technical problems of poor transdermal effect, uncontrollable drug metabolic behaviors, non-ideal curative effect and the like of transdermal drug delivery of nano-drugs in skin disease treatment.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and more specifically relates to a dissolvable microneedle patch for targeted diagnosis and treatment of skin diseases and its preparation. Background technique [0002] The skin is the largest organ of the human body, covering the body surface. Its main function is to provide barrier protection for the body, and it is the boundary between the internal environment and the external environment of the human body. It is of great significance for maintaining the stability of the internal environment of the human body. Nowadays, imaging technology provides powerful tools for the diagnosis and treatment of diseases, but there is still little research on how to realize the integration of diagnosis and treatment of skin-related diseases. The development of targeted nanoparticle drug carriers often requires complex synthetic schemes, including supramolecular self-assembly and chemical Grooming, these ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K45/00A61K31/519A61K31/44A61K31/337A61K31/436A61K47/34A61K47/32A61K47/36A61K49/00A61P17/00A61M37/00A61D7/00
CPCA61K9/0021A61K9/7023A61K45/00A61K31/519A61K31/44A61K31/337A61K31/436A61K47/34A61K47/32A61K47/36A61K49/0032A61P17/00A61M37/0015A61D7/00A61M2037/0023A61M2037/0046A61M2037/0053A61M2037/0061
Inventor 瞿飞毕舵航付阳雪刘奕静张连斌朱锦涛
Owner HUAZHONG UNIV OF SCI & TECH
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