Cell micro-injection device and robust impedance control method thereof

A microinjection and impedance control technology, applied in the fields of biomedical engineering and precision control, can solve the problems of mechanism fatigue failure, unstable steady-state error, inability to compliant mechanism to achieve stiffness ratio, etc., to improve the success rate and reduce assembly. Error, avoid the effect of system instability

Pending Publication Date: 2021-11-02
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] (1) Fatigue problem: Fatigue problem is a major cause of failure of the compliant mechanism, especially for the compliant guide mechanism that adopts a high-frequency vibration strategy for puncturing.
The inherent stress concentration problem of concentrated compliant mechanism is more likely to cause fatigue failure of the mechanism
[0005] (2) Stiffness problem: The lateral vibration of the compliant mechanism depends on the lateral stiffness in principle, and the plane mechanism can only increase the stiffness perpendicular to the plane direction by increasing the thickness, which will lead to the coupling of stiffness in all directions, and cannot make the compliant mechanism Achieving an ideal stiffness ratio
[0006] (3) Parasitic motion problem: the circumferential asymmetry of the planar mechanism cannot eliminate the circumferential coupling error caused by the input, resulting in the generation of later

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cell micro-injection device and robust impedance control method thereof
  • Cell micro-injection device and robust impedance control method thereof
  • Cell micro-injection device and robust impedance control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0033] The technical solutions of the present invention will be further described below with reference to the accompanying drawings.

[0034] like Figure 1 to 4 As shown, the cell microspactic apparatus of the present invention includes a connecting rod 1, a package 2, a piezoelectric driver 3, an injector 4, a hub type compliant mechanism 5, a fixing collet 6, a microsuriode 7.

[0035] The connecting rod 1 includes a threaded portion 11, a connecting portion 12, wherein the threaded portion 11 is connected to the fixed collet 6, and the fixing collet 6 is fixed to the outer side of the hub stuff mechanism 5, and there is a threaded portion 11 The nut is adjusted by the rotating nut to adjust the relative position of the connecting rod 1; the pressing portion 13 is abutting at one end of the package 2, and when the nut is tightened, the piezoelectric driver 3 in the package 2 is generated. The action of the preload force, the piezoelectric driver 3 uses piezoelectric ceramics wit...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a cell micro-injection device which comprises a connecting rod, a packaging device connected with the connecting rod, a piezoelectric actuator fixed in the packaging device, a micro-injection needle, an injector and a hub type compliant mechanism, and the two ends of the injector are connected with the packaging device and the hub type compliant mechanism respectively, the micro-injection needle is fixedly connected with the hub type compliant mechanism; the hub type compliant mechanism is provided with a reed type compliant unit used for transmitting axial vibration to the microinjection needle. According to the micro-injection device, the transverse vibration of the needle head in the micro-injection device can be reduced, and the damage to cells in the cell puncture process is reduced.

Description

technical field [0001] The invention relates to the technical field of precision control and the field of biomedical engineering, in particular to a cell microinjection device and a robust impedance control method thereof. Background technique [0002] Microinjection technology is a technology that manipulates a micromanipulator to control a microinjection needle to manipulate cells or early embryos under a high-power inverted microscope. It is widely used in drug development, in vitro fertilization, biological cloning, transgenic and other fields. The core of microinjection technology is to puncture cells or early embryos with high efficiency and low damage. Due to the low success rate and low efficiency of manual puncture, the puncture process began to develop towards automation. Automatic puncture technology widely uses piezoelectric actuators to drive microinjection needles to complete the puncture process. However, studies have shown that the piezoelectric signal can ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C12M1/36C12M1/34C12M1/32C12M1/00C12Q3/00
CPCC12M33/07C12M35/04C12M41/00C12Q3/00
Inventor 段榆洲凌杰朱玉川陈龙郑述峰张洺铭
Owner NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap