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Method for measuring content of gypsum in traditional Chinese medicine decoction

A technology of traditional Chinese medicine decoction and determination method, which is applied in the field of medicine and achieves the effects of accurate determination, high sensitivity and simple operation.

Pending Publication Date: 2021-11-02
GUANGDONG YIFANG PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Based on this, it is necessary to aim at the problem of inaccurate detection of gypsum in Chinese medicine decoction. The main purpose of the present invention is to provide a method for measuring the content of gypsum in Chinese medicine decoction. high degree

Method used

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  • Method for measuring content of gypsum in traditional Chinese medicine decoction
  • Method for measuring content of gypsum in traditional Chinese medicine decoction
  • Method for measuring content of gypsum in traditional Chinese medicine decoction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Embodiment 1, calcium ion content determination

[0098] 1 Instruments and reagents

[0099] Instrument: ion chromatograph (Dionex ICS-6000, Thermo Fisher Scientific Co., Ltd.); cation suppressor (CSRS300 4mm, Thermo Fisher Scientific Co., Ltd.); IonPac CG12A guard column (4×50mm, 8 μm); IonPacCS12A analytical column (4×250mm, 8μm); ten-thousandth analytical balance (ME204E, Mettler-Toledo); ultrapure water system (Milli-Q Direct, Merck Co., Ltd.).

[0100] Reagents: hydrochloric acid (Guangzhou Chemical Reagent Factory, superior grade); methanesulfonic acid (Aladdin Reagent (Shanghai) Co., Ltd., 99.5%); water is ultrapure water (self-made in the laboratory).

[0101] Reagent: calcium single element solution standard substance (National Institute of Metrology, concentration: 1000μg / mL, batch number: GBW(E)080118); calcium sulfate dihydrate reference substance (batch number: 202004171 Source: Beijing Century Aoke Biotechnology Co., Ltd. company; content: 99.5%); the ba...

Embodiment 2

[0151] Embodiment 2, sulfate ion content determination

[0152] 1 Instruments and reagents

[0153] Instrument: ion chromatograph (Dionex ICS-6000, Thermo Fisher Scientific Co., Ltd.); cation suppressor (CSRS300 4mm, Thermo Fisher Scientific Co., Ltd.); IonPac AG14 guard column (4×50mm, 9 μm); IonPacAS14 analytical column (4×250mm, 9μm); ten-thousandth analytical balance (ME204E, Mettler-Toledo); ultrapure water system (Milli-Q Direct, Merck AG).

[0154] Reagents: hydrochloric acid (Guangzhou Chemical Reagent Factory, superior grade); anhydrous sodium carbonate (Aladdin Reagent (Shanghai) Co., Ltd., superior grade); sodium bicarbonate (Aladdin Reagent (Shanghai) Co., Ltd., superior grade) ; Water is ultrapure water (laboratory self-made).

[0155] Reagent: standard substance of sulfate solution (Beijing Northern Weiye Institute of Metrology, concentration: 1000μg / mL, batch number: BWZ6783-2016); calcium sulfate dihydrate reference substance (lot number: 202004171; source: B...

Embodiment 3

[0199] This embodiment is a modification example of embodiment 2. The main change relative to embodiment 2 is "2.3 Preparation of the test solution". Specifically, the preparation of the test solution in this embodiment includes the following steps:

[0200] Take about 0.1g of gypsum standard decoction, weigh it accurately, put it in a 30ml plastic bottle, accurately add 25ml of 1.35% hydrochloric acid, shake it fully to dissolve, shake well, then accurately absorb 0.1ml of the above solution, add ultrapure water to dilute to 10ml, shake well, filter, take the filtrate, that is.

[0201] Result: according to the preparation method of the above test solution, extract the Ca in the gypsum standard decoction with 25ml of 1.35% hydrochloric acid solution. 2+ , SO 4 2- , and determine the content of the two, measured Ca 2+ The content is 232.54mg / g, SO 4 2- The content is 549.32mg / g. see Figure 5 .

[0202] The present embodiment has also tested Ca in the gypsum standard d...

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Abstract

The invention relates to a method for determining the content of gypsum in a traditional Chinese medicine decoction, which comprises the following steps: respectively preparing a reference substance solution and a test solution, and detecting the reference substance solution and the test solution by ion chromatography, wherein the reference substance solution comprises a reference substance solution containing Ca<2+> or / and a reference substance solution containing SO4<2->; and in the process of preparing the test solution, dissolving the traditional Chinese medicine decoction to be detected by hydrochloric acid. According to the method, the traditional Chinese medicine decoction to be detected is pretreated with hydrochloric acid, calcium ions and sulfate ions in the test solution obtained through pretreatment are in a completely free state, and when the test solution is loaded to ion chromatography for detection, the content of gypsum is accurately determined. Meanwhile, the method also has the advantages of simplicity in operation, rapidness in detection, high sensitivity, good selectivity and good repeatability.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a method for determining the content of gypsum in traditional Chinese medicine decoctions. Background technique [0002] Gypsum is a sulfate mineral gypsum group gypsum, mainly containing hydrous calcium sulfate (CaSO 4 2H 2 O), after excavation, it is necessary to remove miscellaneous stones and sediment. Gypsum is an authentic medicinal material in Hubei Province, and it is also a mineral traditional Chinese medicine with clinical characteristics and advantages. It has the effects of clearing away heat and purging fire, relieving restlessness and quenching thirst. , headaches, and toothaches. Studies have found that in addition to a large amount of calcium, gypsum also contains rich trace elements, such as: magnesium (Mg), zinc (Zn), manganese (Mn), copper (Cu), iron (Fe), strontium (Sr), etc. . According to the regulations, the hydrated calcium sulfate in gy...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/042Y02A50/30
Inventor 李国卫吴文平黄跃前杨晓东刘晓琳邱韵静索彩仙程学仁魏梅孙冬梅陈向东
Owner GUANGDONG YIFANG PHARMA
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