Mild, cool and antipruritic composition and preparation method thereof

A composition and cooling technology, applied in the directions of drug combinations, active ingredients of hydroxy compounds, pharmaceutical formulations, etc., can solve the problems of decreased cooling effect, irritated taste of cooling agents, skin irritation, etc., and can increase the duration of action and prolong the reception of information. ability, the effect of relieving the discomfort of the body

Active Publication Date: 2021-11-05
西安德诺海思医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, menthol is mostly used as a cooling agent, and the cooling effect is relatively strong, but menthol has strong volatility, and the cooling effect time is not long-lasting, and with the prolongation of use and storage time, its cooling effect declines rapidly ;Usually increase the amount of cooling agent to achieve the purpose of prolonging the cooling effect time, but the higher concentration will not significantly improve the duration, but will cause some irritation to the skin, causing local pain and even burning on the skin. burning sensation
[0003] In order to overcome the problems of peppermint-based cooli

Method used

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  • Mild, cool and antipruritic composition and preparation method thereof
  • Mild, cool and antipruritic composition and preparation method thereof
  • Mild, cool and antipruritic composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A mild, cool and antipruritic composition, comprising the following raw materials in weight percentage: 10% of mass concentration 50% ethanol solution, 1% of cooling agent, 1% of soothing anti-inflammatory agent, 10% of moisturizing agent, 0.04% of polymer, and 0.005 of pH regulator % and the balance are water; that is, 10g of mass concentration 50% ethanol solution, 1g of cooling agent, 1g of soothing anti-inflammatory agent, 10g of propylene glycol, 0.04g of polymer, 0.005g of sodium hydroxide, and 77.955g of water;

[0026] The cooling agent is composed of 0.2 g of menthane carboxamide, 0.6 g of methyl diisopropyl propionamide and N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide with a mass ratio of 1:3:1 0.2g mixed;

[0027] The soothing anti-inflammatory agent is formed by mixing 0.5 g of 4-tert-butylcyclohexanol and 0.5 g of bisabolol in a mass ratio of 1:1;

[0028] The polymer is prepared by mixing 0.02 g of ammonium acryloyldimethyltaurate / VP copolymer and 0.02...

Embodiment 2

[0030] A mild, cool and antipruritic composition, comprising the following raw materials in weight percentage: 20% of mass concentration 40% ethanol solution, 4% of cooling agent, 2% of soothing anti-inflammatory agent, 20% of moisturizing agent, 0.15% of polymer, and 0.03 of pH regulator % and the balance is water; that is, 20g of mass concentration 40% ethanol solution, 4g of cooling agent, 2g of soothing anti-inflammatory agent, 20g of glycerin, 0.15g of polymer, 0.03g of arginine, and 53.82g of water;

[0031] The cooling agent is 1.6g of menthanecarboxamide, 0.8g of methyldiisopropylpropionamide and N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide with a mass ratio of 2:1:2. 1.6g mixed;

[0032] The soothing anti-inflammatory agent is formed by mixing 1.2 g of 4-tert-butylcyclohexanol and 0.8 g of bisabolol with a mass ratio of 3:2;

[0033] The polymer was prepared by mixing 0.05g polyacrylate crosspolymer-6 and 0.10g ammonium acryloyldimethyltaurate / VP copolymer.

Embodiment 3

[0035]A mild, cool and antipruritic composition, comprising the following raw materials in weight percentage: 15% of mass concentration 45% ethanol solution, 3% of cooling agent, 1.5% of soothing anti-inflammatory agent, 15% of moisturizing agent, 0.10% of polymer, and 0.025 of pH regulator % and the balance are water; that is, 15g of mass concentration 45% ethanol solution, 3g of cooling agent, 1.5g of soothing anti-inflammatory agent, 15g of butanediol, 0.1g of polymer, 0.025g of potassium hydroxide, and 65.375g of water;

[0036] The cooling agent is mixed with 1g of menthanecarboxamide, 1g of methyldiisopropylpropionamide and 1g of N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide with a mass ratio of 1:1:1. made;

[0037] The soothing anti-inflammatory agent is formed by mixing 1.125g of 4-tert-butylcyclohexanol and 0.375g of bisabolol with a mass ratio of 3:1;

[0038] The polymer is prepared by mixing 0.02 g of ammonium polyacryloyl dimethyl taurate and 0.08 g of TR-1 po...

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PUM

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Abstract

The invention provides a mild, cool and antipruritic composition and a preparation method thereof. The mild, cool and antipruritic composition comprises the following raw materials in percentage by weight: 10%-20% of an ethanol solution, 1%-4% of a freshener, 1%-2% of a soothing anti-inflammatory agent, 10%-20% of a humectant, 0.04%-0.15% of a polymer, 0.005%-0.03% of a pH regulator and the balance of water, wherein the freshener is formed by mixing menthane formyl ethylamine, methyl diisopropyl propionamide and N-(ethoxycarbonylmethyl)-p-alkyl-3-formamide according to the mass ratio of (1-2): (1-4): (1-2), and the soothing anti-inflammatory agent is formed by mixing 4-tert-butyl cyclohexanol and bisabolol according to the mass ratio of (1-4): (1-2). According to the mild, cool and antipruritic composition in scientific proportion and the preparation method of the mild, cool and antipruritic composition, strong irritation of menthol derivatives to skin is reduced, the skin can be relieved, a mild and rapid antipruritic effect is achieved, the product is long in cool feeling lasting time, and a long-acting antipruritic effect is achieved; and on the other hand, the product has excellent environmental stability and stable quality.

Description

technical field [0001] The invention relates to the field of medicine and chemical industry, in particular to a mild, refreshing and antipruritic composition and a preparation method thereof. Background technique [0002] Cooling agent, usually refers to the general term for substances that can produce a cooling effect and are not strong in medicinal properties. Commonly used cooling agents are mainly mint-type cooling agents. to cool. In the prior art, menthol is mostly used as a cooling agent, and the cooling effect is relatively strong, but menthol has strong volatility, and the cooling effect time is not long-lasting, and with the prolongation of use and storage time, its cooling effect declines rapidly ;Usually increase the amount of cooling agent to achieve the purpose of prolonging the cooling effect time, but the higher concentration will not significantly improve the duration, but will cause some irritation to the skin, causing local pain and even burning on the sk...

Claims

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Application Information

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IPC IPC(8): A61K31/16A61K47/10A61K47/32A61P17/00A61P17/04A61K31/045
CPCA61K31/045A61K31/16A61K47/32A61K47/10A61P17/04A61P17/00A61K2300/00
Inventor 党秀洁刘影
Owner 西安德诺海思医疗科技有限公司
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