Mild, cool and antipruritic composition and preparation method thereof

Abstract

The invention provides a mild, cool and antipruritic composition and a preparation method thereof. The mild, cool and antipruritic composition comprises the following raw materials in percentage by weight: 10%-20% of an ethanol solution, 1%-4% of a freshener, 1%-2% of a soothing anti-inflammatory agent, 10%-20% of a humectant, 0.04%-0.15% of a polymer, 0.005%-0.03% of a pH regulator and the balance of water, wherein the freshener is formed by mixing menthane formyl ethylamine, methyl diisopropyl propionamide and N-(ethoxycarbonylmethyl)-p-alkyl-3-formamide according to the mass ratio of (1-2): (1-4): (1-2), and the soothing anti-inflammatory agent is formed by mixing 4-tert-butyl cyclohexanol and bisabolol according to the mass ratio of (1-4): (1-2). According to the mild, cool and antipruritic composition in scientific proportion and the preparation method of the mild, cool and antipruritic composition, strong irritation of menthol derivatives to skin is reduced, the skin can be relieved, a mild and rapid antipruritic effect is achieved, the product is long in cool feeling lasting time, and a long-acting antipruritic effect is achieved; and on the other hand, the product has excellent environmental stability and stable quality.

Description

technical field [0001] The invention relates to the field of medicine and chemical industry, in particular to a mild, refreshing and antipruritic composition and a preparation method thereof. Background technique [0002] Cooling agent, usually refers to the general term for substances that can produce a cooling effect and are not strong in medicinal properties. Commonly used cooling agents are mainly mint-type cooling agents. to cool. In the prior art, menthol is mostly used as a cooling agent, and the cooling effect is relatively strong, but menthol has strong volatility, and the cooling effect time is not long-lasting, and with the prolongation of use and storage time, its cooling effect declines rapidly ;Usually increase the amount of cooling agent to achieve the purpose of prolonging the cooling effect time, but the higher concentration will not significantly improve the duration, but will cause some irritation to the skin, causing local pain and even burning on the sk...

AI Technical Summary

Problems solved by technology

In the prior art, menthol is mostly used as a cooling agent, and the cooling effect is relatively strong, but menthol has strong volatility, and the cooling effect time is not long-lasting, and with the prolongation of use and storage time, its cooling effect declines rapidly ;Usually increase the amount of cooling agent to achieve the purpose of prolonging the cooling effect time, but the higher concentration will not significantly improve the duration, but will cause some irritation to the skin, causing local pain and even burning on the skin. burning sensation

[0003] In order to overcome the problems of peppermint-based cooling agents that are irritating in taste, not mild to the skin, highly volatile, and have a short duration, the prior art mostly uses menthol derivatives such as menthyl esters and menthyl amides to replace menthol. The solubility of these products is poor, usually using ethanol solution with higher concentration and dosage to dissolve, and ethanol solution with high concentration and high dosage has strong irritation to the skin; existing products in high temperature or low temperature, high water content environment, There are also defects such as crystallization and water-oil separation, which make the product quality unstable

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