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Nanometer magnetic microsphere, preparation method thereof and application of nanometer magnetic microsphere in detection of drugs and metabolites thereof

A nano-magnetic and nano-sphere technology, applied in chemical instruments and methods, measuring devices, and other chemical processes, can solve long-term problems, improve detection efficiency, shorten sample pretreatment time and detection time, and improve detection accuracy degree of effect

Pending Publication Date: 2021-11-23
SHANGHAI CRIMINAL SCI TECH RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Due to the current detection of drugs in sewage takes a long time to get the test results

Method used

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  • Nanometer magnetic microsphere, preparation method thereof and application of nanometer magnetic microsphere in detection of drugs and metabolites thereof
  • Nanometer magnetic microsphere, preparation method thereof and application of nanometer magnetic microsphere in detection of drugs and metabolites thereof

Examples

Experimental program
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Effect test

preparation example 1

[0053] The institutional preparation provides a nanomagnetic microsphere, the preparation method is as follows:

[0054] (1) 1.5 g of iron chloride is dissolved into 70 mL of ethylene glycol, and 1.5 g sodium citrate is added. After stirring for 1 hour, 5 g sodium acetate, stirred, and then add to the polytetrafluoroethylene reactor, put it in an oven The reaction was reacted at 190 ° C for 20 hours. After cooling to 25 ° C, clean it with deionized, dry at 60 ° C, resulting in single-point ultra-metallomagnetic tetraned iron nanosphere (Fe 3 O 4 .

[0055] (2) 5 g of the above-mentioned single-dispersed superclant magnetic tetraned iron nanosphere is dispersed in 600 ml of ethanol and 170 ml of deionized water, and the ultrasound is dispersed for 18 minutes, and 5 mL of ammonia water (30% mass fraction) is added, and the normal silicate is added after mixing. Ethyl ester 5 mL, methacrylate-3- (trimethoxysilyl) propyl ester 3 ml, 25 ° C for 13 hours, resulting in double bond modifi...

preparation example 2

[0058] The institutional preparation provides a nanomagnetic microsphere, the preparation method is as follows:

[0059] (1) 0.5 g of iron chloride dissolved in 70 mL of ethylene glycol, add 0.1 g of sodium maleate, stirred for 1 hour, then add 8 g of sodium acetate, stir, add to the polytetrafluoroethylene reactor, put it in The oven reaction was reacted at 160 ° C for 30 hours. After cooling to 25 ° C, clean it with deionized, dry at 60 ° C, resulting in single-point ultra-metallomagnetic tetraned iron nanosphere (Fe 3 O 4 .

[0060] (2) 1 g of the above-mentioned single-dispersed superclamps magnetic tetrashydoxide is dispersed in 600 ml of ethanol and 170 ml of deionized water, and the ultrasonic dispersion is 5 minutes, and 2 mL of ammonia water (25% mass fraction) is added, and the normal silicate is added after mixing. Ethyl ester 1 mL, methacrylate-3- (trimethoxysilyl) propyl 1 ml, 20 ° C for 15 hours, resulting in double bond modification modified magnetic silica microsph...

preparation example 3

[0063] The institutional preparation provides a nanomagnetic microsphere, the preparation method is as follows:

[0064] (1) 3 g of iron chloride was added to 70 mL of ethylene glycol, and 3 g of sodium oxalate was added. After stirring for 1 hour, 2 g of sodium acetate, stirred, and added to the polytetrafluoroethylene reaction kettle, placed in an oven at 220 ° C The reaction was reacted for 5 hours. After cooling to 25 ° C, clean it with deionized, dry at 60 ° C, resulting in single-point ultra-metallomagnetic tetraned iron nanosphere (Fe 3 O 4 .

[0065] (2) 10 g of the above-mentioned single-dispersed superclant magnetic tetraned oxide is dispersed in 1000 ml of ethanol and 230 ml of deionized water, and the ultrasound is dispersed for 30 minutes, and 8 ml of sodium hydroxide (35% mass fraction) is added, and the niebron is added after mixing. Tetrate 10ml, methacrylate-3- (trimeoxysiloxane) propyl ester 5 ml, 30 ° C for 12 hours, to obtain double-bond modified magnetic silic...

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Abstract

The invention provides a nanometer magnetic microsphere, a preparation method thereof and application of the nanomemter magnetic microsphere in detection of drugs and metabolites thereof, and the preparation method comprises the following steps: (1) mixing iron salt with a chelating agent and an alkaline precipitator for reaction to obtain ferroferric oxide nanospheres; (2) mixing the ferroferric oxide nanospheres obtained in the step (1) with a solvent for ultrasonic treatment, and then conducting mixing with an alkaline regulator, tetraethyl orthosilicate and methacrylic acid-3-(trimethoxysilyl)propyl ester for reaction to obtain double-bond modified magnetic silicon dioxide microspheres; and (3) mixing the double-bond modified magnetic silicon dioxide microspheres obtained in the step (2) with a hydrophilic compound, a lipophilic compound and an initiator for reaction to obtain the nanometer magnetic microspheres. The nanometer magnetic microspheres provided by the invention are simple to prepare, can quickly complete detection when being applied to drug detection, and consumes less time.

Description

Technical field [0001] The present invention belongs to the field of drug detection, in particular to a nano magnetic microspheres and its preparation method and application of the detection of drug metabolites and in particular relates to a method for detecting the speed of the fast magnetic nanoparticles and microspheres preparation and testing of drugs and application of its metabolites. Background technique [0002] Many modern cities, DuQing complex, different drug manufacturing drug characteristics of each region, poison drugs and their metabolites have been widely present in the sewage collection system, and for the status and trends of drug poisons most of the area sewage unclear . Consumption of drugs sewage analysis method can be used to evaluate a large area (city or country) and small regional specific populations (workplace, schools, prisons, etc.), available in drug addiction types of trends or new drugs through short-term or long-term sample testing kind of informa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/286B01J20/30G01N27/62
CPCB01J20/286G01N27/62
Inventor 杨飞宇
Owner SHANGHAI CRIMINAL SCI TECH RES INST
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