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Laminarin compound as well as preparation method and application thereof

A technology of lamina polysaccharides and polysaccharides, applied in the field of lamina polysaccharides and their preparation, can solve the problems of strong or weak antioxidant activity, weakened cell activity, lipid peroxidation, etc., to improve columnar epithelial structure and increase expression The effect of increasing the amount of flexion and extension

Active Publication Date: 2021-12-10
SHANTOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A certain level of free radicals has a positive effect on intestinal immune function, but excessive free radicals can cause intestinal damage, lipid peroxidation, weaken cell activity, and even aging. The degree can reflect the strength of antioxidant activity

Method used

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  • Laminarin compound as well as preparation method and application thereof
  • Laminarin compound as well as preparation method and application thereof
  • Laminarin compound as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] A preparation method of lamina polysaccharides, comprising the following steps:

[0059] (1) Add laminarin and methyl isonicotinate to toluene, wherein: the mass volume ratio of laminarin and methyl isonicotinate is 1g:15mL, the temperature is 120°C, fill with nitrogen as a protective gas, stir and reflux for 48 hours , and then rotary evaporated at 65°C to obtain a solid product;

[0060] (2) Add the solid product obtained in step (1) into dimethyl sulfoxide to dissolve, wherein: the mass volume ratio of the solid product to dimethyl sulfoxide is 1g: 10mL, stir evenly at room temperature, and dissolve liquid;

[0061] (3) Add 1,3-propane sultone to dimethyl sulfoxide, wherein: the volume ratio of 1,3-propane sultone and dimethyl sulfoxide is 1:2, and then add it dropwise In the lysate prepared in step (2), mix uniformly to obtain a reaction solution;

[0062] (4) Stir the reaction solution prepared in step (3) at 80°C for 48 hours, and pour it into acetone at 4°C af...

Embodiment 2

[0067] A preparation method of lamina polysaccharides, comprising the following steps:

[0068] (1) Add laminarin and methyl isonicotinate to toluene, wherein: the mass volume ratio of laminarin and methyl isonicotinate is 1g:10mL, the temperature is 130°C, fill with nitrogen as a protective gas, stir and reflux for 48 hours , and then rotary evaporated at 65°C to obtain a solid product;

[0069] (2) Add the solid product obtained in step (1) into dimethyl sulfoxide to dissolve, wherein: the mass volume ratio of the solid product to dimethyl sulfoxide is 1g: 15mL, stir evenly at room temperature, and dissolve liquid;

[0070] (3) Add 1,3-propane sultone to dimethyl sulfoxide, wherein: the volume ratio of 1,3-propane sultone and dimethyl sulfoxide is 1:1.5, and then add it dropwise In the lysate prepared in step (2), mix uniformly to obtain a reaction solution;

[0071] (4) Stir the reaction solution prepared in step (3) at 90°C for 36 hours, and pour it into acetone at 4°C ...

Embodiment 3

[0076] A preparation method of lamina polysaccharides, comprising the following steps:

[0077] (1) Add laminarin and methyl isonicotinate to toluene, wherein: the mass volume ratio of laminarin and methyl isonicotinate is 1g:20mL, the temperature is 110°C, fill with nitrogen as a protective gas, stir and reflux for 36 hours , and then rotary evaporated at 75°C to obtain a solid product;

[0078] (2) Add the solid product obtained in step (1) into dimethyl sulfoxide to dissolve, wherein: the mass volume ratio of the solid product to dimethyl sulfoxide is 1g: 20mL, stir evenly at room temperature, and dissolve liquid;

[0079] (3) Add 1,3-propane sultone to dimethyl sulfoxide, wherein: the volume ratio of 1,3-propane sultone and dimethyl sulfoxide is 1:2.5, and then add it dropwise In the lysate prepared in step (2), mix uniformly to obtain a reaction solution;

[0080] (4) Stir the reaction solution prepared in step (3) at 70°C for 60 hours, and pour it into acetone at 4°C ...

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Abstract

The invention belongs to the technical field of biological medicine, and particularly discloses a laminarin compound and a preparation method and application thereof. The laminarin compound is laminarin modified by a sulfonic acid group; the preparation method comprises the following steps: adding laminarin, pyridine and / or a pyridine derivative into an organic solvent, reacting, and drying to obtain a solid product; adding the solid product into an organic solvent for dissolving to obtain a dissolved solution; adding an organic matter containing a sulfonic acid group into an organic solvent, then adding the dissolving solution, and mixing to obtain a reaction solution; and heating the reaction liquid, cooling, pouring into an organic solvent, and drying to obtain the kelp polysaccharide compound. The pyridine laminarin sulfonate modified by the sulfonic acid group can regulate the intestinal mucous barrier and improve the expression quantity of mucoprotein MUC2; and redundant intestinal free radicals are removed, normal functions of the intestinal tract are maintained, and the preparation method is suitable for preparing the intestinal barrier repairing medicine.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a laminarin compound, a preparation method and application thereof. Background technique [0002] With the continuous improvement of people's living standards, the diet structure is becoming more and more unreasonable, with too much intake of high-sugar, high-fat, and high-salt foods, and insufficient intake of dietary polysaccharides. This change in eating habits has caused a series of intestinal problems, which seriously threaten the health of the intestinal tract. Once the intestinal mucosa is destroyed, it can lead to abnormal intestinal permeability, and exogenous harmful substances will invade the host intestine, which will lead to various intestinal diseases and even systemic reactions, which will have very serious consequences for the human body, such as inflammatory bowel disease Inflammatory bowel diseases such as , ulcerative colitis and Crohn's diseas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715A61P1/00
CPCC08B37/00A61K31/715A61P1/00
Inventor 张杰良余标李云峰
Owner SHANTOU UNIV
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