Concealment of hypomineralised lesions
A technology for shaping calcium fluoride phosphate and tooth surfaces, applied in the field of compositions that reduce the visibility of hypomineralized tooth surfaces or subsurfaces, and can solve problems such as reduced sensitivity, low compliance with remineralization, and poor patient prognosis
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Embodiment 1
[0291] Preparation of High Concentration Liquid CPP-ACFP and CPP-ACP Solutions
[0292] 3.25M CaCl 2 and 1.25M NaH 2 PO 4 (pH 5.5) stock solution in approximately 30 aliquots to a 10-15% w / v tryptic digest of casein until just before precipitation or gelation (typically yielding approximately 78 mM to 124 mM Ca 2+ and a final concentration of 48mM to 76mM inorganic phosphate). The solution was added slowly (ie, less than about 1% by volume per minute) with good agitation. Add one part phosphate solution first, followed by one part calcium solution. The pH of the bulk solution was maintained at 9.0 using 1 to 10 M NaOH with thorough mixing. Sodium hydroxide solution is added automatically by the pH stat, usually with hydroxide ions after each addition of calcium ions. After the addition of calcium ions, phosphate ions and hydroxide ions is complete, the solution is filtered through a 0.1 micron filter to concentrate 1-2 times. The retentate was then washed with 1-2 volum...
Embodiment 2
[0295] Masking of Vitiligo Lesions Using CPP-ACP and Alkaline Solutions
[0296] A 45% w / v CPP-ACP, pH 5.5 liquid solution was applied (within seconds) to the surface of the enamel block with the leukoplakia lesion using a microbrush. The enamel blocks were then incubated at 37 °C for 20 min. A 1M NaOH solution (approximately pH 14) was then applied (within a few seconds) with a microbrush, and the enamel pieces were incubated at 37°C for a further 20 min.
[0297] figure 1 Shown are leukoplakia lesions after treatment (T) compared to control lesions (C) from the same lesion (ie enamel block cut in half). Vitiligo lesions in the treated samples were substantially masked by the treatment by returning the lesions to translucency compared to control samples in which the leukoplakia lesions were still clearly visible.
Embodiment 3
[0299] Masking of leukoplakia lesions using 63% w / v CPP-ACP, free fluoride and alkaline solution
[0300] A liquid solution of 63% w / v CPP-ACP and 8,200 ppm F (as NaF), pH 5.5, was applied (within seconds) to the surface of enamel blocks with leukoplakia lesions using a microbrush. The enamel blocks were then incubated at 37 °C for 20 min. A 1M NaOH solution was then applied (within a few seconds) with a microbrush, and the enamel blocks were incubated at 37°C for a further 20 min.
[0301] figure 2 Shown is a treated leukoplakia lesion (T) on the left compared to a control lesion on the right (C) from the same lesion (ie enamel block cut in half). Vitiligo lesions in the treated samples were substantially masked by the treatment by returning the lesions to translucency compared to control samples in which the leukoplakia lesions were still clearly visible.
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