Stable small-peptide chelated calcium as well as preparation method and application thereof

A small peptide chelating and stabilizing technology, applied in the field of protein salt processing, can solve problems such as poor calcium supplementation effect, unsatisfactory calcium absorption rate, poor thermal stability, etc., and achieve high calcium chelation rate and raw material Low cost, good effect of calcium supplementation

Active Publication Date: 2021-12-21
SHANDONG ANWEIXIAN BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patented technology uses lecithin, sucrose, and maltodextrin to make a wall material solution for embedding. The heat stability is not good, the calcium absorption rate is not ideal, and the calcium supplement effect is not good.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A preparation method of stable small peptide chelated calcium, the specific steps are as follows:

[0032] (1) First use pig bone as raw material, crush it into pig bone powder with a particle size of 5 μm or less, extract with water, enzymatic hydrolyze twice, and dialyze to obtain a small peptide mixture with a molecular weight cut-off lower than 1000 Da;

[0033] (2) Then add calcium chloride solution to the small peptide mixed solution, stir and react to obtain the small peptide chelated calcium solution;

[0034] (3) Add sodium alginate to the small peptide chelated calcium solution, stir until completely dissolved, then add ultrafine calcium carbonate suspension, stir and mix to obtain a premixed solution, and then add the premixed solution drop by drop to D-glucose In the lactone solution, keep stirring until a uniform sol is formed, keep it airtight, and filter to obtain microspheres;

[0035] (4) Finally, dissolve polyvinyl alcohol in water, then add carboxyme...

Embodiment 2

[0046] A preparation method of stable small peptide chelated calcium, the specific steps are as follows:

[0047] (1) First use pig bone as raw material, crush it into pig bone powder with a particle size of 5 μm or less, extract with water, enzymatic hydrolyze twice, and dialyze to obtain a small peptide mixture with a molecular weight cut-off lower than 1000 Da;

[0048] (2) Then add calcium chloride solution to the small peptide mixed solution, stir and react to obtain the small peptide chelated calcium solution;

[0049] (3) Add sodium alginate to the small peptide chelated calcium solution, stir until completely dissolved, then add ultrafine calcium carbonate suspension, stir and mix to obtain a premixed solution, and then add the premixed solution drop by drop to D-glucose In the lactone solution, keep stirring until a uniform sol is formed, keep it airtight, and filter to obtain microspheres;

[0050] (4) Finally, dissolve polyvinyl alcohol in water, then add carboxyme...

Embodiment 3

[0061] A preparation method of stable small peptide chelated calcium, the specific steps are as follows:

[0062] (1) First use pig bone as raw material, crush it into pig bone powder with a particle size of 5 μm or less, extract with water, enzymatic hydrolyze twice, and dialyze to obtain a small peptide mixture with a molecular weight cut-off lower than 1000 Da;

[0063] (2) Then add calcium chloride solution to the small peptide mixed solution, stir and react to obtain the small peptide chelated calcium solution;

[0064] (3) Add sodium alginate to the small peptide chelated calcium solution, stir until completely dissolved, then add ultrafine calcium carbonate suspension, stir and mix to obtain a premixed solution, and then add the premixed solution drop by drop to D-glucose In the lactone solution, keep stirring until a uniform sol is formed, keep it airtight, and filter to obtain microspheres;

[0065] (4) Finally, dissolve polyvinyl alcohol in water, then add carboxyme...

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Abstract

The invention discloses stable small-peptide chelated calcium and a preparation method and application thereof. The preparation method comprises the steps: firstly, preparing a small-peptide mixed solution by taking pig bones as raw materials, then, adding a calcium chloride solution into the small-peptide mixed solution, and carrying out a reaction with stirring, so as to obtain a small-peptide chelated calcium solution; adding sodium alginate into the small-peptide chelated calcium solution, carrying out stirring until the sodium alginate is completely dissolved, then, adding a superfine calcium carbonate suspension, carrying out uniform stirring and mixing to obtain a premix, then, dropwise adding the premix into a D-glucolactone solution, continuously to perform stirring until uniform sol is formed, carrying out sealing and standing, and carrying out filtering to obtain microspheres; and finally, dissolving polyvinyl alcohol in water, then, adding carboxymethyl chitosan and the microspheres, carrying out uniform stirring and mixing, adding glutaraldehyde with stirring, continuously to perform stirring to obtain hydrogel, and carrying out drying, thereby obtaining the stable small-peptide chelated calcium. The preparation method of the stable small-peptide chelated calcium is low in raw material cost, and the obtained product is high in calcium chelation rate and good in calcium supplement effect.

Description

technical field [0001] The invention relates to a stable small peptide chelated calcium, a preparation method and an application. The invention belongs to the technical field of protein salt processing. Background technique [0002] Proteinate is a metal complex formed by coordinating soluble salts with proteins, peptides or amino acids. Specifically, metal ions are coordinated with amino groups, carboxyl groups, and sulfhydryl groups in proteins, peptides, or amino acids. The chemical and biochemical stability of protein salt is far superior to that of inorganic substances or complexes, and it plays an important role in the absorption and metabolism of metal elements and improves bioavailability. Among them, the protein, peptide or amino acid attached to the metal element in the proteinate fundamentally determines the absorption efficiency of the metal ion. The absorption of macromolecular proteins is not good, the type of specific amino acid is single, and the cost of ami...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/01A61K9/06A61K47/36A61P3/02C07K1/107C12P21/06
CPCA61K38/014A61K9/06A61K47/36A61P3/02C12P21/06C07K1/107
Inventor 张钦强王湧郭宝震沈彩芹郭泗华翟婷
Owner SHANDONG ANWEIXIAN BIOLOGICAL TECH CO LTD
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