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Two-component injectable in-situ functional hydrogel biological material and preparation method thereof

A biomaterial and injection-based technology, applied in pharmaceutical formulation, drug delivery, medical science, etc., can solve the problems of insufficient elasticity of polysilicone hydrogel, inability of hydrogel to meet the user's comfort needs, and high oxygen permeability , to achieve the effect of good elasticity, easy raw materials and simple equipment

Inactive Publication Date: 2022-01-21
天衍医疗器材有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a two-component injectable in-situ functional hydrogel biomaterial and its preparation method, which solves the problem that the advanced hydrogel in the prior art is made of polysilicone monomer. Ketone hydrogels have higher oxygen permeability than traditional hydrogels. However, polysilicone hydrogels have insufficient elasticity, and the resulting hydrogels cannot meet the needs of users for comfort.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A two-component injectable in situ functional hydrogel biomaterial, including a water-soluble polyether polymer with terminal group functionalization as the first component of the hydrogel biomaterial, and an amino functionalized macromolecule as the second component. Two components, and then the first component and the second component are quickly and uniformly mixed through a syringe; wherein: the mass percentage of the terminal functionalized water-soluble polyether polymer of the first component is 4-13% , the mass percent of the amino-rich macromolecules of the second component is 2-8%, and the hydrogel is directly prepared from the raw materials for preparing the hydrogel and water according to the mass ratio of 1: (3.4-5.1). Mixed, heated and then cooled, the raw materials for preparing the hydrogel include 2 parts of sodium alginate, 8 parts of acrylamide, 0.0997 to 0.1659 parts of calcium sulfate, 0.00075 to 0.00225 parts of photocrosslinked Agent, 0.04-0.12 pa...

Embodiment 2

[0025] The first component is a functionalized polyether polymer whose end group is an NHS carboxylate group, specifically any one of linear, multi-armed or dendritic functionalized polyethylene glycol polymers. The second component is any of amino-rich natural or chemically modified or synthetic polymers, specifically chitosan and chemically modified chitosan, polylysine, amino-modified collagen or polyetheramine Any one of them, the second component is a natural or chemically modified or synthetic polymer rich in amino groups, wherein the molecular weight of chitosan or chemically modified chitosan is 120kDa~149kDa; The molecular weight of polylysine is 3.7kDa~9kDa; The molecular weight of amino-modified collagen is 90kDa~99kDa; The molecular weight of polyetheramine is 3kDa~18kDa, and the photoinitiator is selected from 2-hydroxyl-4'-(2 At least one of -hydroxyethoxy)-2-methylpropiophenone and diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide, the sodium alginate and the ac...

Embodiment 3

[0027] A method for preparing a two-component injectable in-situ functional hydrogel biomaterial, the first component and the second component are quickly and uniformly mixed through a syringe, wherein: the first component and the second component are quickly When mixing, the ratio of solid content is 5:3 to 1:8; then after sterilization and packaging, the required product is obtained, and the equipment required for the preparation method of the above-mentioned two-component injectable in-situ functional hydrogel biomaterial The method is simple, the process steps are simple and convenient, the raw materials are easy to obtain, and the industrialized production is easy to realize.

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Abstract

The invention relates to the technical field of hydrogel, in particular to a two-component injectable in-situ functional hydrogel biological material and a preparation method thereof, and solves the problems that in the prior art, advanced hydrogel is silicone which is prepared from a silicone monomer, has the oxygen permeability superior to that of traditional hydrogel, but is insufficient in elasticity, while the prepared hydrogel cannot meet the requirement of users for comfort. According to the two-component injectable in-situ functional hydrogel biomaterial and the preparation method thereof, the hydrogel biomaterial is prepared by using an end-functionalized water-soluble polyether polymer as a first component and an amino-functionalized polymer as a second component, and then rapidly and uniformly mixing the first component and the second component through an injector. The elasticity of the hydrogel is effectively improved, the applicability of the hydrogel is improved, and the requirement for the comfort level of a user can be met.

Description

technical field [0001] The invention relates to the field of hydrogel technology, in particular to a two-component injectable in-situ functional hydrogel biomaterial and a preparation method thereof. Background technique [0002] Hydrogel is a kind of hydrated cross-linked polymer, which is soft in nature, can maintain a certain shape, and can absorb a large amount of water. Hydrogel is insoluble in water, but can swell in water. Due to its high water content, excellent Swellability, good biocompatibility, high permeability and 3D network structure are widely used in the fields of tissue engineering, wound repair and regenerative medicine. Hydrogels usually have oxygen permeability and biocompatibility, so they are very suitable for to produce medical biomaterials. [0003] However, advanced hydrogels are made of polysilicone monomers, and their oxygen permeability is higher than that of traditional hydrogels. However, polysilicone hydrogels have insufficient elasticity, so...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/20A61L27/24A61L27/50A61L27/52A61L31/04A61L31/14A61L31/02A61L27/02
CPCA61L27/18A61L27/20A61L27/24A61L27/52A61L27/50A61L31/048A61L31/044A61L31/042A61L31/145A61L31/14A61L31/028A61L27/025A61L2400/06C08L71/02C08L5/04
Inventor 魏崇斌
Owner 天衍医疗器材有限公司