Application of plasma metabolite in aspect of diagnosing severity of Parkinson's disease

Abstract

The invention discloses an application of a plasma metabolite in the aspect of diagnosing the severity of Parkinson's disease, and particularly relates to an application of the plasma metabolite in preparing a detection reagent or a detection substance for diagnosing the severity of Parkinson's disease. The plasma metabolite comprises plasma branched-chain amino acid and / or aromatic amino acid, the branched-chain amino acid is selected from one or a combination of three of leucine, isoleucine and valine, and the aromatic amino acid is tyrosine and / or phenylalanine. Plasma is taken as a sample, a biological sample is easy to obtain, simple and convenient to collect, large in quantity, low in price and short in detection period, the severity of the PD disease can be judged by detecting plasma markers, and the method is a reliable, efficient, convenient and fast novel method and has good application prospects in treatment and prognosis of PD patients.

Description

Technical field [0001] The invention is within the field of biomedical, and specific applications involving plasma metabolites in diagnosis of Parkinson's severity. Background technique [0002] Parkinson's Disease (PD) is a common middle and agricultural neurological degenerative disease. The main pathological changes are bleed in black dopaminergic neurons to perform sex degeneration and Louis miniature formation, with static tremors, muscle strength, Non-motion symptoms such as exercise delay, posture balance obstacles, constipation, constipation, abnormal sleep behavior, and depression are significant. The symptoms of PD patients gradually increase, and the severity of the assessment of symptoms is critical to the development of reasonable treatment programs and judging the prognosis. [0003] The research on the severity of PD diseases is mainly concentrated in clinical symptoms, biochemistry, imaging and portable equipment, but there are below the following: [0004] (1) Cl...

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Problems solved by technology

Beatriz Jimenez et al. found that the reduction of retinal nerve fiber layer (RNFL) thickness around the optic disc measured by optical coherence tomography (OCT) was related to the increase of UPDRS score in PD patients, suggesting that RNFL thickness is expected to be a biomarker for judging the severity of disease in PD patients (Jiménez, B., Ascaso, F.J., Cristóbal, J.A. & López del Val, J. Development of aprediction formula of Parkinson disease severity by optical coherencetomography. Mov. Disord. 29, 68–74 (2014).), but the above biological Whether the markers can judge the severity of disease in PD patients needs further study

[0007] (4) Portable equipment: MeysamAsgari et al. developed a tool that can be used for remote monitoring at home. This tool collects the speech pronunciation of patients, analyzes its characteristics (such as speech speed, pitch, harmonic-to-noise ratio, etc.), and uses specific algorithm processing. Judgment of disease severity (Asgari, M. & Shafran, I. Predicting severity of Parkinson's disease from speech. 2010 Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. 2010, 5201–5204 (2010).), the The method is still in the experimental stage, and it is not clear whether it can be put into clinical application

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